Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults

High-titer convalescent plasma was compared with placebo in older adult patients within the first 3 days after the onset of symptoms of Covid-19 and documented SARS-CoV-2 infection. Disease progression was approximately half as common in patients who received convalescent plasma (16%) as in those wh...

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Vydáno v:	The New England journal of medicine Ročník 384; číslo 7; s. 610 - 618
Hlavní autoři:	Libster, Romina, Pérez Marc, Gonzalo, Wappner, Diego, Coviello, Silvina, Bianchi, Alejandra, Braem, Virginia, Esteban, Ignacio, Caballero, Mauricio T, Wood, Cristian, Berrueta, Mabel, Rondan, Aníbal, Lescano, Gabriela, Cruz, Pablo, Ritou, Yvonne, Fernández Viña, Valeria, Álvarez Paggi, Damián, Esperante, Sebastián, Ferreti, Adrián, Ofman, Gastón, Ciganda, Álvaro, Rodriguez, Rocío, Lantos, Jorge, Valentini, Ricardo, Itcovici, Nicolás, Hintze, Alejandra, Oyarvide, M. Laura, Etchegaray, Candela, Neira, Alejandra, Name, Ivonne, Alfonso, Julieta, López Castelo, Rocío, Caruso, Gisela, Rapelius, Sofía, Alvez, Fernando, Etchenique, Federico, Dimase, Federico, Alvarez, Darío, Aranda, Sofía S, Sánchez Yanotti, Clara, De Luca, Julián, Jares Baglivo, Sofía, Laudanno, Sofía, Nowogrodzki, Florencia, Larrea, Ramiro, Silveyra, María, Leberzstein, Gabriel, Debonis, Alejandra, Molinos, Juan, González, Miguel, Perez, Eduardo, Kreplak, Nicolás, Pastor Argüello, Susana, Gibbons, Luz, Althabe, Fernando, Bergel, Eduardo, Polack, Fernando P
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Massachusetts Medical Society 18.02.2021
Témata:	Adverse events Age Aged Aged, 80 and over Antibodies Blood Component Transfusion Cardiovascular disease Chronic obstructive pulmonary disease Consent Coronaviridae Coronaviruses COVID-19 COVID-19 - complications COVID-19 - therapy COVID-19 Serotherapy Diabetes Disease Progression Double-Blind Method Female Geriatrics Humans Hypertension Illnesses Immunization, Passive Immunoglobulin G Immunoglobulin G - blood Intention to Treat Analysis Kaplan-Meier Estimate Male Older people Original Pandemics Patients Placebos Plasma Respiration Respiratory diseases Respiratory Insufficiency - etiology Respiratory Insufficiency - prevention & control SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Argentina
ISSN:	0028-4793, 1533-4406, 1533-4406
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Shrnutí:	High-titer convalescent plasma was compared with placebo in older adult patients within the first 3 days after the onset of symptoms of Covid-19 and documented SARS-CoV-2 infection. Disease progression was approximately half as common in patients who received convalescent plasma (16%) as in those who received placebo (31%).
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3 The Fundación INFANT–COVID-19 Group members are listed in the Supplementary Appendix, available with the full text of this article at NEJM.org. Drs. Libster and Pérez Marc contributed equally to this article.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa2033700