Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults
High-titer convalescent plasma was compared with placebo in older adult patients within the first 3 days after the onset of symptoms of Covid-19 and documented SARS-CoV-2 infection. Disease progression was approximately half as common in patients who received convalescent plasma (16%) as in those wh...
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| Published in: | The New England journal of medicine Vol. 384; no. 7; pp. 610 - 618 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Massachusetts Medical Society
18.02.2021
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| Subjects: | |
| ISSN: | 0028-4793, 1533-4406, 1533-4406 |
| Online Access: | Get full text |
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| Abstract | High-titer convalescent plasma was compared with placebo in older adult patients within the first 3 days after the onset of symptoms of Covid-19 and documented SARS-CoV-2 infection. Disease progression was approximately half as common in patients who received convalescent plasma (16%) as in those who received placebo (31%). |
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| AbstractList | Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, perhaps because antibodies should be administered earlier in the course of illness.
We conducted a randomized, double-blind, placebo-controlled trial of convalescent plasma with high IgG titers against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in older adult patients within 72 hours after the onset of mild Covid-19 symptoms. The primary end point was severe respiratory disease, defined as a respiratory rate of 30 breaths per minute or more, an oxygen saturation of less than 93% while the patient was breathing ambient air, or both. The trial was stopped early at 76% of its projected sample size because cases of Covid-19 in the trial region decreased considerably and steady enrollment of trial patients became virtually impossible.
A total of 160 patients underwent randomization. In the intention-to-treat population, severe respiratory disease developed in 13 of 80 patients (16%) who received convalescent plasma and 25 of 80 patients (31%) who received placebo (relative risk, 0.52; 95% confidence interval [CI], 0.29 to 0.94; P = 0.03), with a relative risk reduction of 48%. A modified intention-to-treat analysis that excluded 6 patients who had a primary end-point event before infusion of convalescent plasma or placebo showed a larger effect size (relative risk, 0.40; 95% CI, 0.20 to 0.81). No solicited adverse events were observed.
Early administration of high-titer convalescent plasma against SARS-CoV-2 to mildly ill infected older adults reduced the progression of Covid-19. (Funded by the Bill and Melinda Gates Foundation and the Fundación INFANT Pandemic Fund; Dirección de Sangre y Medicina Transfusional del Ministerio de Salud number, PAEPCC19, Plataforma de Registro Informatizado de Investigaciones en Salud number, 1421, and ClinicalTrials.gov number, NCT04479163.). BackgroundTherapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, perhaps because antibodies should be administered earlier in the course of illness.MethodsWe conducted a randomized, double-blind, placebo-controlled trial of convalescent plasma with high IgG titers against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in older adult patients within 72 hours after the onset of mild Covid-19 symptoms. The primary end point was severe respiratory disease, defined as a respiratory rate of 30 breaths per minute or more, an oxygen saturation of less than 93% while the patient was breathing ambient air, or both. The trial was stopped early at 76% of its projected sample size because cases of Covid-19 in the trial region decreased considerably and steady enrollment of trial patients became virtually impossible.ResultsA total of 160 patients underwent randomization. In the intention-to-treat population, severe respiratory disease developed in 13 of 80 patients (16%) who received convalescent plasma and 25 of 80 patients (31%) who received placebo (relative risk, 0.52; 95% confidence interval [CI], 0.29 to 0.94; P=0.03), with a relative risk reduction of 48%. A modified intention-to-treat analysis that excluded 6 patients who had a primary end-point event before infusion of convalescent plasma or placebo showed a larger effect size (relative risk, 0.40; 95% CI, 0.20 to 0.81). No solicited adverse events were observed.ConclusionsEarly administration of high-titer convalescent plasma against SARS-CoV-2 to mildly ill infected older adults reduced the progression of Covid-19. (Funded by the Bill and Melinda Gates Foundation and the Fundación INFANT Pandemic Fund; Dirección de Sangre y Medicina Transfusional del Ministerio de Salud number, PAEPCC19, Plataforma de Registro Informatizado de Investigaciones en Salud number, 1421, and ClinicalTrials.gov number, NCT04479163.) Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, perhaps because antibodies should be administered earlier in the course of illness.BACKGROUNDTherapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, perhaps because antibodies should be administered earlier in the course of illness.We conducted a randomized, double-blind, placebo-controlled trial of convalescent plasma with high IgG titers against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in older adult patients within 72 hours after the onset of mild Covid-19 symptoms. The primary end point was severe respiratory disease, defined as a respiratory rate of 30 breaths per minute or more, an oxygen saturation of less than 93% while the patient was breathing ambient air, or both. The trial was stopped early at 76% of its projected sample size because cases of Covid-19 in the trial region decreased considerably and steady enrollment of trial patients became virtually impossible.METHODSWe conducted a randomized, double-blind, placebo-controlled trial of convalescent plasma with high IgG titers against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in older adult patients within 72 hours after the onset of mild Covid-19 symptoms. The primary end point was severe respiratory disease, defined as a respiratory rate of 30 breaths per minute or more, an oxygen saturation of less than 93% while the patient was breathing ambient air, or both. The trial was stopped early at 76% of its projected sample size because cases of Covid-19 in the trial region decreased considerably and steady enrollment of trial patients became virtually impossible.A total of 160 patients underwent randomization. In the intention-to-treat population, severe respiratory disease developed in 13 of 80 patients (16%) who received convalescent plasma and 25 of 80 patients (31%) who received placebo (relative risk, 0.52; 95% confidence interval [CI], 0.29 to 0.94; P = 0.03), with a relative risk reduction of 48%. A modified intention-to-treat analysis that excluded 6 patients who had a primary end-point event before infusion of convalescent plasma or placebo showed a larger effect size (relative risk, 0.40; 95% CI, 0.20 to 0.81). No solicited adverse events were observed.RESULTSA total of 160 patients underwent randomization. In the intention-to-treat population, severe respiratory disease developed in 13 of 80 patients (16%) who received convalescent plasma and 25 of 80 patients (31%) who received placebo (relative risk, 0.52; 95% confidence interval [CI], 0.29 to 0.94; P = 0.03), with a relative risk reduction of 48%. A modified intention-to-treat analysis that excluded 6 patients who had a primary end-point event before infusion of convalescent plasma or placebo showed a larger effect size (relative risk, 0.40; 95% CI, 0.20 to 0.81). No solicited adverse events were observed.Early administration of high-titer convalescent plasma against SARS-CoV-2 to mildly ill infected older adults reduced the progression of Covid-19. (Funded by the Bill and Melinda Gates Foundation and the Fundación INFANT Pandemic Fund; Dirección de Sangre y Medicina Transfusional del Ministerio de Salud number, PAEPCC19, Plataforma de Registro Informatizado de Investigaciones en Salud number, 1421, and ClinicalTrials.gov number, NCT04479163.).CONCLUSIONSEarly administration of high-titer convalescent plasma against SARS-CoV-2 to mildly ill infected older adults reduced the progression of Covid-19. (Funded by the Bill and Melinda Gates Foundation and the Fundación INFANT Pandemic Fund; Dirección de Sangre y Medicina Transfusional del Ministerio de Salud number, PAEPCC19, Plataforma de Registro Informatizado de Investigaciones en Salud number, 1421, and ClinicalTrials.gov number, NCT04479163.). High-titer convalescent plasma was compared with placebo in older adult patients within the first 3 days after the onset of symptoms of Covid-19 and documented SARS-CoV-2 infection. Disease progression was approximately half as common in patients who received convalescent plasma (16%) as in those who received placebo (31%). |
| Author | Valentini, Ricardo López Castelo, Rocío Silveyra, María Caruso, Gisela Ritou, Yvonne De Luca, Julián Debonis, Alejandra Esteban, Ignacio Pérez Marc, Gonzalo Rodriguez, Rocío Name, Ivonne Libster, Romina Ferreti, Adrián Dimase, Federico Bianchi, Alejandra Laudanno, Sofía Neira, Alejandra Rondan, Aníbal Caballero, Mauricio T Cruz, Pablo Bergel, Eduardo Lescano, Gabriela Oyarvide, M. Laura Kreplak, Nicolás Nowogrodzki, Florencia Pastor Argüello, Susana Alvarez, Darío Lantos, Jorge Itcovici, Nicolás Alfonso, Julieta Ciganda, Álvaro Wood, Cristian Etchegaray, Candela Aranda, Sofía S Fernández Viña, Valeria Molinos, Juan Braem, Virginia Etchenique, Federico Larrea, Ramiro Jares Baglivo, Sofía Esperante, Sebastián Hintze, Alejandra Álvarez Paggi, Damián González, Miguel Alvez, Fernando Gibbons, Luz Althabe, Fernando Polack, Fernando P Ofman, Gastón Leberzstein, Gabriel Berrueta, Mabel Coviello, Silvina Perez, Eduardo Rapelius, Sofía Wappner, Diego Sánchez Yanotti, Clara |
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Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 10 givenname: Mabel surname: Berrueta fullname: Berrueta, Mabel organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 11 givenname: Aníbal surname: Rondan fullname: Rondan, Aníbal organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 12 givenname: Gabriela surname: Lescano fullname: Lescano, Gabriela organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 13 givenname: Pablo surname: Cruz fullname: Cruz, Pablo organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 14 givenname: Yvonne surname: Ritou fullname: Ritou, Yvonne organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 15 givenname: Valeria surname: Fernández Viña fullname: Fernández Viña, Valeria organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 16 givenname: Damián surname: Álvarez Paggi fullname: Álvarez Paggi, Damián organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 17 givenname: Sebastián surname: Esperante fullname: Esperante, Sebastián organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 18 givenname: Adrián surname: Ferreti fullname: Ferreti, Adrián organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 19 givenname: Gastón surname: Ofman fullname: Ofman, Gastón organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 20 givenname: Álvaro surname: Ciganda fullname: Ciganda, Álvaro organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 21 givenname: Rocío surname: Rodriguez fullname: Rodriguez, Rocío organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 22 givenname: Jorge surname: Lantos fullname: Lantos, Jorge organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 23 givenname: Ricardo surname: Valentini fullname: Valentini, Ricardo organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 24 givenname: Nicolás surname: Itcovici fullname: Itcovici, Nicolás organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 25 givenname: Alejandra surname: Hintze fullname: Hintze, Alejandra organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 26 givenname: M. Laura surname: Oyarvide fullname: Oyarvide, M. Laura organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 27 givenname: Candela surname: Etchegaray fullname: Etchegaray, Candela organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 28 givenname: Alejandra surname: Neira fullname: Neira, Alejandra organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 29 givenname: Ivonne surname: Name fullname: Name, Ivonne organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 30 givenname: Julieta surname: Alfonso fullname: Alfonso, Julieta organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 31 givenname: Rocío surname: López Castelo fullname: López Castelo, Rocío organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 32 givenname: Gisela surname: Caruso fullname: Caruso, Gisela organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 33 givenname: Sofía surname: Rapelius fullname: Rapelius, Sofía organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 34 givenname: Fernando surname: Alvez fullname: Alvez, Fernando organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 35 givenname: Federico surname: Etchenique fullname: Etchenique, Federico organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 36 givenname: Federico surname: Dimase fullname: Dimase, Federico organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 37 givenname: Darío surname: Alvarez fullname: Alvarez, Darío organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 38 givenname: Sofía S surname: Aranda fullname: Aranda, Sofía S organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 39 givenname: Clara surname: Sánchez Yanotti fullname: Sánchez Yanotti, Clara organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 40 givenname: Julián surname: De Luca fullname: De Luca, Julián organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 41 givenname: Sofía surname: Jares Baglivo fullname: Jares Baglivo, Sofía organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 42 givenname: Sofía surname: Laudanno fullname: Laudanno, Sofía organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 43 givenname: Florencia surname: Nowogrodzki fullname: Nowogrodzki, Florencia organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 44 givenname: Ramiro surname: Larrea fullname: Larrea, Ramiro organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 45 givenname: María surname: Silveyra fullname: Silveyra, María organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 46 givenname: Gabriel surname: Leberzstein fullname: Leberzstein, Gabriel organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 47 givenname: Alejandra surname: Debonis fullname: Debonis, Alejandra organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 48 givenname: Juan surname: Molinos fullname: Molinos, Juan organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 49 givenname: Miguel surname: González fullname: González, Miguel organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 50 givenname: Eduardo surname: Perez fullname: Perez, Eduardo organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 51 givenname: Nicolás surname: Kreplak fullname: Kreplak, Nicolás organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 52 givenname: Susana surname: Pastor Argüello fullname: Pastor Argüello, Susana organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 53 givenname: Luz surname: Gibbons fullname: Gibbons, Luz organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 54 givenname: Fernando surname: Althabe fullname: Althabe, Fernando organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 55 givenname: Eduardo surname: Bergel fullname: Bergel, Eduardo organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) – sequence: 56 givenname: Fernando P surname: Polack fullname: Polack, Fernando P organization: From Fundación INFANT (R. Libster, S.C., A.B., I.E., M.T.C., C.W., D.A.P., S.E., A.F., G.O., S.S.A., C.S.Y., J.D.L., S.J.B., S.L., F.N., F.P.P.), iTrials (R. Libster, G.P.M., D.W., S.C., A.B., V.B., S.S.A., F.P.P.), Swiss Medical Group (D.W., J.L., F.E., J.M.), National Scientific and Technical Research Council (M.T.C., D.A.P., S.E.), Hospital Dr. Carlos Bocalandro (A.R., G. Lescano), Centro Gallego (P.C.), Instituto de Efectividad Clínica y Sanitaria (M.B., A.C., R.R., L.G., E.B.), Hospital Simplemente Evita (V.F.V.), CEMIC (R.V.), Fundación Hematológica Sarmiento (F. Alvez), Hospital Municipal San Isidro, (R. Larrea), Sanatorio Anchorena Recoleta (M.S.), Sanatorio Sagrado Corazón, Obra Social de los Empleados de Comercio y Actividades Civiles (G. Leberzstein), Ministerio de Salud de la Provincia de Buenos Aires (A.D., N.K.), Sanatorio Finochietto (M.G.), Programa de Atención Médica Integral (E.P.), Hospital Militar Central (G.P.M., V.B., C.W., N.I., A.H., M.L.O., C.E., A.N., I.N., J.A., R.L.C., G.C., S.R., F.D., D.A., S.P.A.), and Hospital San Juan de Dios (Y.R.) — all in Buenos Aires; the University of Oklahoma, Norman (G.O.); and the United Nations Development Program–United Nations Population Fund–United Nations Children’s Fund–World Health Organization–World Bank Special Program of Research, Development, and Research Training in Human Reproduction, Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva (F. Althabe) |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33406353$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2021 Massachusetts Medical Society. All rights reserved. Copyright © 2021 Massachusetts Medical Society. Copyright © 2021 Massachusetts Medical Society. All rights reserved. 2021 Massachusetts Medical Society |
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| Snippet | High-titer convalescent plasma was compared with placebo in older adult patients within the first 3 days after the onset of symptoms of Covid-19 and documented... Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to... BackgroundTherapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to... |
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| SubjectTerms | Adverse events Age Aged Aged, 80 and over Antibodies Blood Component Transfusion Cardiovascular disease Chronic obstructive pulmonary disease Consent Coronaviridae Coronaviruses COVID-19 COVID-19 - complications COVID-19 - therapy COVID-19 Serotherapy Diabetes Disease Progression Double-Blind Method Female Geriatrics Humans Hypertension Illnesses Immunization, Passive Immunoglobulin G Immunoglobulin G - blood Intention to Treat Analysis Kaplan-Meier Estimate Male Older people Original Pandemics Patients Placebos Plasma Respiration Respiratory diseases Respiratory Insufficiency - etiology Respiratory Insufficiency - prevention & control SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index |
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| Title | Early High-Titer Plasma Therapy to Prevent Severe Covid-19 in Older Adults |
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