Curcumin modulates gut microbiota and improves renal function in rats with uric acid nephropathy

It is well known that the progression of hyperuricemia disease often contributes to renal dysfunction. However, there have been few studies on uric acid nephropathy (UAN), especially its relationship with gut microbiota. UAN is usually accompanied by disordered intestinal flora, and damaged gut barr...

Full description

Saved in:
Bibliographic Details
Published in:Renal failure Vol. 43; no. 1; pp. 1063 - 1075
Main Authors: Xu, Xueling, Wang, Huifang, Guo, Dandan, Man, Xiaofei, Liu, Jun, Li, Junying, Luo, Congjuan, Zhang, Ming, Zhen, Li, Liu, Xuemei
Format: Journal Article
Language:English
Published: New York Taylor & Francis 01.01.2021
Taylor & Francis Ltd
Taylor & Francis Group
Subjects:
Apoptosis
Creatinine
Curcumin
Digestive system
Endotoxemia
Fatty acids
Fibrosis
Gastrointestinal tract
Gut microbiota
Hyperuricemia
Inflammation
intestinal barrier
Intestinal microflora
Intestine
Laboratory Study
Metabolism
Microbiota
Nephropathy
Next-generation sequencing
Opportunist infection
Renal function
Uric acid
uric acid nephropathy
ISSN:0886-022X, 1525-6049, 1525-6049
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract It is well known that the progression of hyperuricemia disease often contributes to renal dysfunction. However, there have been few studies on uric acid nephropathy (UAN), especially its relationship with gut microbiota. UAN is usually accompanied by disordered intestinal flora, and damaged gut barrier, which are closely related to tubulointerstitial fibrosis, and systemic inflammation. In previous studies, it has been confirmed that curcumin could alleviate tubulointerstitial fibrosis, and improve renal function through its antioxidant, anti-apoptotic, and anti-inflammatory efficacies. However, the effects curcumin exerts on intestinal flora in uric acid nephropathy are still unknown. Therefore, we used next-generation sequencing technology to investigate the effects of curcumin on gut microbiota in a rat model of UAN induced by adenine and potassium oxonate, and rats were randomly divided into control, model or curcumin treatment groups. The results demonstrated that, compared to the model group, the treatment group showed decreased serum uric acid (156.80 ± 11.90 μmol/L vs. 325.60 ± 18.65 μmol/L, p < 0.001), serum creatinine (66.20 ± 11.88 μmol/L vs. 182.20 ± 8.87 μmol/L, p < 0.001) and BUN level (13.33 ± 3.16 mmol/L vs. 36.04 ± 6.60 mmol/L, p < 0.001). The treatment group also displayed attenuated renal pathological lesions and metabolic endotoxemia (25.60 ± 5.90 ng/mL vs. 38.40 ± 4.98 ng/mL, p < 0.01), and improved tightly linked proteins expression. Besides, curcumin altered the gut microbiota structure in UAN rats. More specifically, curcumin treatment protected against the overgrowth of opportunistic pathogens in UAN, including Escherichia-Shigella and Bacteroides, and increased the relative abundance of bacteria producing short-chain fatty acids (SCFAs), such as Lactobacillus and Ruminococcaceae. These results suggest that curcumin could modulate gut microbiota, fortify the intestinal barrier, attenuate metabolic endotoxemia, and consequently protect the renal function in UAN rats.
AbstractList It is well known that the progression of hyperuricemia disease often contributes to renal dysfunction. However, there have been few studies on uric acid nephropathy (UAN), especially its relationship with gut microbiota. UAN is usually accompanied by disordered intestinal flora, and damaged gut barrier, which are closely related to tubulointerstitial fibrosis, and systemic inflammation. In previous studies, it has been confirmed that curcumin could alleviate tubulointerstitial fibrosis, and improve renal function through its antioxidant, anti-apoptotic, and anti-inflammatory efficacies. However, the effects curcumin exerts on intestinal flora in uric acid nephropathy are still unknown. Therefore, we used next-generation sequencing technology to investigate the effects of curcumin on gut microbiota in a rat model of UAN induced by adenine and potassium oxonate, and rats were randomly divided into control, model or curcumin treatment groups. The results demonstrated that, compared to the model group, the treatment group showed decreased serum uric acid (156.80 ± 11.90 μmol/L vs. 325.60 ± 18.65 μmol/L, p < 0.001), serum creatinine (66.20 ± 11.88 μmol/L vs. 182.20 ± 8.87 μmol/L, p < 0.001) and BUN level (13.33 ± 3.16 mmol/L vs. 36.04 ± 6.60 mmol/L, p < 0.001). The treatment group also displayed attenuated renal pathological lesions and metabolic endotoxemia (25.60 ± 5.90 ng/mL vs. 38.40 ± 4.98 ng/mL, p < 0.01), and improved tightly linked proteins expression. Besides, curcumin altered the gut microbiota structure in UAN rats. More specifically, curcumin treatment protected against the overgrowth of opportunistic pathogens in UAN, including Escherichia-Shigella and Bacteroides, and increased the relative abundance of bacteria producing short-chain fatty acids (SCFAs), such as Lactobacillus and Ruminococcaceae. These results suggest that curcumin could modulate gut microbiota, fortify the intestinal barrier, attenuate metabolic endotoxemia, and consequently protect the renal function in UAN rats.It is well known that the progression of hyperuricemia disease often contributes to renal dysfunction. However, there have been few studies on uric acid nephropathy (UAN), especially its relationship with gut microbiota. UAN is usually accompanied by disordered intestinal flora, and damaged gut barrier, which are closely related to tubulointerstitial fibrosis, and systemic inflammation. In previous studies, it has been confirmed that curcumin could alleviate tubulointerstitial fibrosis, and improve renal function through its antioxidant, anti-apoptotic, and anti-inflammatory efficacies. However, the effects curcumin exerts on intestinal flora in uric acid nephropathy are still unknown. Therefore, we used next-generation sequencing technology to investigate the effects of curcumin on gut microbiota in a rat model of UAN induced by adenine and potassium oxonate, and rats were randomly divided into control, model or curcumin treatment groups. The results demonstrated that, compared to the model group, the treatment group showed decreased serum uric acid (156.80 ± 11.90 μmol/L vs. 325.60 ± 18.65 μmol/L, p < 0.001), serum creatinine (66.20 ± 11.88 μmol/L vs. 182.20 ± 8.87 μmol/L, p < 0.001) and BUN level (13.33 ± 3.16 mmol/L vs. 36.04 ± 6.60 mmol/L, p < 0.001). The treatment group also displayed attenuated renal pathological lesions and metabolic endotoxemia (25.60 ± 5.90 ng/mL vs. 38.40 ± 4.98 ng/mL, p < 0.01), and improved tightly linked proteins expression. Besides, curcumin altered the gut microbiota structure in UAN rats. More specifically, curcumin treatment protected against the overgrowth of opportunistic pathogens in UAN, including Escherichia-Shigella and Bacteroides, and increased the relative abundance of bacteria producing short-chain fatty acids (SCFAs), such as Lactobacillus and Ruminococcaceae. These results suggest that curcumin could modulate gut microbiota, fortify the intestinal barrier, attenuate metabolic endotoxemia, and consequently protect the renal function in UAN rats.
It is well known that the progression of hyperuricemia disease often contributes to renal dysfunction. However, there have been few studies on uric acid nephropathy (UAN), especially its relationship with gut microbiota. UAN is usually accompanied by disordered intestinal flora, and damaged gut barrier, which are closely related to tubulointerstitial fibrosis, and systemic inflammation. In previous studies, it has been confirmed that curcumin could alleviate tubulointerstitial fibrosis, and improve renal function through its antioxidant, anti-apoptotic, and anti-inflammatory efficacies. However, the effects curcumin exerts on intestinal flora in uric acid nephropathy are still unknown. Therefore, we used next-generation sequencing technology to investigate the effects of curcumin on gut microbiota in a rat model of UAN induced by adenine and potassium oxonate, and rats were randomly divided into control, model or curcumin treatment groups. The results demonstrated that, compared to the model group, the treatment group showed decreased serum uric acid (156.80 ± 11.90 μmol/L vs. 325.60 ± 18.65 μmol/L, p < 0.001), serum creatinine (66.20 ± 11.88 μmol/L vs. 182.20 ± 8.87 μmol/L, p < 0.001) and BUN level (13.33 ± 3.16 mmol/L vs. 36.04 ± 6.60 mmol/L, p < 0.001). The treatment group also displayed attenuated renal pathological lesions and metabolic endotoxemia (25.60 ± 5.90 ng/mL vs. 38.40 ± 4.98 ng/mL, p < 0.01), and improved tightly linked proteins expression. Besides, curcumin altered the gut microbiota structure in UAN rats. More specifically, curcumin treatment protected against the overgrowth of opportunistic pathogens in UAN, including Escherichia-Shigella and Bacteroides, and increased the relative abundance of bacteria producing short‐chain fatty acids (SCFAs), such as Lactobacillus and Ruminococcaceae. These results suggest that curcumin could modulate gut microbiota, fortify the intestinal barrier, attenuate metabolic endotoxemia, and consequently protect the renal function in UAN rats.
Author Man, Xiaofei
Liu, Xuemei
Luo, Congjuan
Zhen, Li
Xu, Xueling
Wang, Huifang
Guo, Dandan
Li, Junying
Liu, Jun
Zhang, Ming
Author_xml – sequence: 1
  givenname: Xueling
  surname: Xu
  fullname: Xu, Xueling
  organization: Department of Nephrology, The Affiliated Hospital of Qingdao University
– sequence: 2
  givenname: Huifang
  surname: Wang
  fullname: Wang, Huifang
  organization: Department of Nephrology, The Affiliated Hospital of Qingdao University
– sequence: 3
  givenname: Dandan
  surname: Guo
  fullname: Guo, Dandan
  organization: Department of Nephrology, The Affiliated Hospital of Qingdao University
– sequence: 4
  givenname: Xiaofei
  surname: Man
  fullname: Man, Xiaofei
  organization: Department of Nephrology, The Affiliated Hospital of Qingdao University
– sequence: 5
  givenname: Jun
  surname: Liu
  fullname: Liu, Jun
  organization: Department of Nephrology, The Affiliated Hospital of Qingdao University
– sequence: 6
  givenname: Junying
  surname: Li
  fullname: Li, Junying
  organization: Department of Nephrology, The Affiliated Hospital of Qingdao University
– sequence: 7
  givenname: Congjuan
  surname: Luo
  fullname: Luo, Congjuan
  organization: Department of Nephrology, The Affiliated Hospital of Qingdao University
– sequence: 8
  givenname: Ming
  surname: Zhang
  fullname: Zhang, Ming
  organization: Department of Nephrology, The Affiliated Hospital of Qingdao University
– sequence: 9
  givenname: Li
  surname: Zhen
  fullname: Zhen, Li
  organization: Department of Nephrology, The Affiliated Hospital of Qingdao University
– sequence: 10
  givenname: Xuemei
  surname: Liu
  fullname: Liu, Xuemei
  organization: Department of Nephrology, The Affiliated Hospital of Qingdao University
BookMark eNqFkkuLFDEUhYOMOA_9CULAjZtuk1SlkiCIQ-NjYMCNgrt4K0l1p6lK2iQ1Q_9703YrzCx0lZD7ncMh91yisxCDQ-glJUtKJHlDpOwIY9-XjDC6pKptpeBP0AXljC860qozdHFgFgfoHF3mvCWEcinYM3TetLReFLtAP1ZzMvPkA56inUcoLuP1XPDkTYq9jwUwBIv9tEvxrs6SCzDiYQ6m-Bhw1SUoGd_7ssFz8gaD8RYHt9ukuIOy2T9HTwcYs3txOq_Qt48fvq4-L26_fLpZXd8uDG9UWfQ97buOKGpaKmjNqayRHSeWNYOkYAQlTjTScgkOBt67QXTCUFIHTBHXN1fo5uhrI2z1LvkJ0l5H8Pr3Q0xrDal4MzotuGp7a4yiFFqnKBDZCTuABeqappfV693Razf3k7PGhZJgfGD6cBL8Rq_jnZaMN1R21eD1ySDFn7PLRU8-GzeOEFycs2a87ZQktGMVffUI3cY51U-ulGCUKCFUWyl-pOpWck5u-BuGEn3og_7TB33ogz71oerePtIZX-Cwuprbj_9Vvz-qfRhimuA-ptHqAvsxpiFBMD7r5t8WvwBA_tDJ
CitedBy_id crossref_primary_10_1007_s00203_022_03053_y
crossref_primary_10_3389_fcimb_2022_1051682
crossref_primary_10_3389_fphar_2023_1115224
crossref_primary_10_1039_D5FO01404B
crossref_primary_10_1111_cbdd_14367
crossref_primary_10_3389_fnut_2022_960309
crossref_primary_10_3390_nu16203530
crossref_primary_10_3390_ijms24021095
crossref_primary_10_3389_fphar_2022_1026246
crossref_primary_10_3389_fcimb_2022_887407
crossref_primary_10_3389_fnut_2024_1407736
crossref_primary_10_1097_IMNA_D_24_00068
crossref_primary_10_3389_fcimb_2024_1483550
crossref_primary_10_1007_s00280_021_04385_0
crossref_primary_10_1016_j_phanu_2025_100450
crossref_primary_10_1016_j_fbio_2025_105944
crossref_primary_10_3389_fmicb_2025_1654152
crossref_primary_10_1016_j_envpol_2023_121335
crossref_primary_10_1016_j_phymed_2024_156335
crossref_primary_10_3390_nu14122498
crossref_primary_10_3390_toxins14100648
crossref_primary_10_2147_JIR_S499343
crossref_primary_10_1002_mnfr_70097
crossref_primary_10_1016_j_phymed_2022_154110
crossref_primary_10_1186_s12964_024_01922_1
crossref_primary_10_3390_ijms251910692
crossref_primary_10_1016_j_scitotenv_2022_160321
crossref_primary_10_1186_s12986_025_00977_2
crossref_primary_10_1016_j_ijpharm_2023_123683
crossref_primary_10_1007_s40263_022_00901_9
crossref_primary_10_1016_j_psep_2024_04_121
crossref_primary_10_1016_j_scitotenv_2023_167696
crossref_primary_10_1016_j_phymed_2023_154979
crossref_primary_10_3390_nu15081989
crossref_primary_10_1186_s12263_025_00766_9
crossref_primary_10_1039_D2FO03332A
crossref_primary_10_1016_j_phrs_2023_106787
crossref_primary_10_1002_jsfa_13677
crossref_primary_10_1016_j_cyto_2022_156120
crossref_primary_10_3389_fnut_2025_1561271
crossref_primary_10_1016_j_biopha_2023_116022
crossref_primary_10_1016_j_phymed_2025_156402
crossref_primary_10_1016_j_joim_2024_06_001
crossref_primary_10_3390_toxins14120859
crossref_primary_10_1371_journal_pone_0314029
crossref_primary_10_1080_1828051X_2023_2297557
crossref_primary_10_1080_0886022X_2025_2506810
crossref_primary_10_1097_MD_0000000000040975
crossref_primary_10_3389_fphar_2025_1517047
crossref_primary_10_3389_fnut_2022_890730
crossref_primary_10_1093_jpp_rgac024
crossref_primary_10_3389_fimmu_2024_1362642
crossref_primary_10_1021_acs_jafc_5c01260
crossref_primary_10_1016_j_aninu_2024_05_011
crossref_primary_10_3389_fphar_2022_1068613
crossref_primary_10_3389_fimmu_2021_813890
crossref_primary_10_1016_j_micpath_2025_108026
crossref_primary_10_1039_D1FO04178A
crossref_primary_10_1016_j_foodchem_2024_140514
crossref_primary_10_2147_DDDT_S389811
crossref_primary_10_3390_nu14132666
Cites_doi 10.1080/13880209.2020.1809462
10.1128/CVI.13.2.219-226.2006
10.1186/gb-2011-12-6-r60
10.1007/s00467-016-3527-x
10.3389/fbioe.2020.00299
10.1007/s00424-020-02352-x
10.1111/bcpt.12817
10.1126/science.1171700
10.1159/000484920
10.3390/toxins10070298
10.1038/nature04516
10.1159/000450619
10.1016/j.cca.2013.02.008
10.1038/s12276-019-0234-2
10.1186/s12891-019-2519-y
10.1186/2047-783X-18-26
10.1371/journal.pone.0223445
10.1038/ki.2012.345
10.1186/1471-2369-15-36
10.1016/j.biocel.2018.01.001
10.1186/s12906-015-0644-1
10.1208/s12248-012-9432-8
10.1111/1750-3841.13793
10.1016/j.jhep.2015.04.018
10.1371/journal.pntd.0007444
10.1097/MIB.0000000000000522
10.1016/j.anaerobe.2013.06.012
10.1038/nrgastro.2017.20
10.1016/j.bpg.2003.10.003
10.1038/s41598-017-02989-2
10.1155/2015/505878
10.1111/j.1365-2982.2012.01921.x
10.1002/art.30520
10.1073/pnas.0812874106
10.1038/nmeth.2604
10.1007/s12275-018-8049-8
10.1038/nmicrobiol.2017.26
10.1016/j.jnutbio.2020.108515
10.1038/srep33052
10.1093/ndt/gfq580
10.1007/s11695-012-0655-7
10.1186/1476-4598-10-12
10.3109/09637486.2015.1064869
10.1016/j.fct.2011.10.070
10.14715/cmb/2017.63.7.3
10.1007/s11906-017-0727-0
10.1080/21688370.2018.1425085
10.1093/ndt/gfu287
10.1007/s00216-012-5929-3
10.1016/j.jconrel.2013.06.032
10.1080/00365520701864627
10.1155/2015/535686
10.1016/j.biopha.2017.07.123
10.3390/jcm7100315
10.1186/1471-2458-4-9
10.1042/CS20180563
10.1016/j.redox.2013.09.003
10.1097/HJH.0b013e328312c8c1
10.2215/CJN.03150318
10.1016/j.jare.2016.11.004
10.1053/j.ajkd.2017.12.009
10.1007/978-0-387-46401-5_20
10.1016/j.apsb.2019.10.007
10.1007/s00018-019-03155-9
10.1007/978-981-10-8684-7_9
10.1016/bs.aambs.2016.06.002
ContentType Journal Article
Copyright 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2021
2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2021 The Author(s)
Copyright_xml – notice: 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2021
– notice: 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2021 The Author(s)
DBID 0YH
AAYXX
CITATION
3V.
7T5
7X7
7XB
88E
8FI
8FJ
8FK
8G5
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
GUQSH
H94
K9.
M0S
M1P
M2O
MBDVC
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
Q9U
7X8
5PM
DOA
DOI 10.1080/0886022X.2021.1944875
DatabaseName Taylor & Francis Open Access
CrossRef
ProQuest Central (Corporate)
Immunology Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
Research Library (Alumni)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials Local Electronic Collection Information
ProQuest Central (subscription)
ProQuest One Community College
ProQuest Central
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Research Library Prep
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
Medical Database
Research Library (subscription)
Research Library (Corporate)
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
AIDS and Cancer Research Abstracts
ProQuest Research Library
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
Immunology Abstracts
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: 0YH
  name: Taylor & Francis Open Access
  url: https://www.tandfonline.com
  sourceTypes: Publisher
– sequence: 3
  dbid: PIMPY
  name: Publicly Available Content Database
  url: http://search.proquest.com/publiccontent
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
DocumentTitleAlternate X. Xu et al
EISSN 1525-6049
EndPage 1075
ExternalDocumentID oai_doaj_org_article_7594bdcc911a4e91a0867dfada1e33b8
PMC8253186
10_1080_0886022X_2021_1944875
1944875
Genre Research Article
GroupedDBID ---
00X
0YH
123
29P
36B
4.4
53G
5RE
7X7
88E
8FI
8FJ
8G5
ABDBF
ABUWG
ACGEJ
ACGFS
ACUHS
ADBBV
ADCVX
ADRBQ
ADXPE
AENEX
AFKRA
AFKVX
AJWEG
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AQTUD
ARJSQ
AZQEC
BABNJ
BCNDV
BENPR
BLEHA
CCPQU
CS3
DWQXO
EAP
EBC
EBD
EBS
EMB
EMK
EMOBN
EPL
ESX
F5P
FYUFA
GNUQQ
GROUPED_DOAJ
GUQSH
H13
HMCUK
HZ~
M1P
M2O
M4Z
O9-
P2P
PHGZM
PHGZT
PIMPY
PJZUB
PPXIY
PROAC
PSQYO
RPM
SV3
TDBHL
TFDNU
TFL
TFW
TUS
UKHRP
V1S
~1N
AAYXX
AFFHD
CITATION
3V.
7T5
7XB
8FK
H94
K9.
MBDVC
PKEHL
PQEST
PQQKQ
PQUKI
Q9U
7X8
5PM
ID FETCH-LOGICAL-c539t-bb1b66091c41711589dc8650d23f81ac710e738d58aeaf5bef767c10c71290eb3
IEDL.DBID DOA
ISICitedReferencesCount 74
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000668370900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 0886-022X
1525-6049
IngestDate Fri Oct 03 12:51:01 EDT 2025
Tue Nov 04 01:40:56 EST 2025
Sun Nov 09 10:22:12 EST 2025
Tue Oct 07 07:08:06 EDT 2025
Tue Nov 18 21:56:50 EST 2025
Sat Nov 29 02:26:00 EST 2025
Mon Oct 20 23:46:41 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License open-access: http://creativecommons.org/licenses/by/4.0/: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c539t-bb1b66091c41711589dc8650d23f81ac710e738d58aeaf5bef767c10c71290eb3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink https://doaj.org/article/7594bdcc911a4e91a0867dfada1e33b8
PMID 34187292
PQID 2721097794
PQPubID 3933335
PageCount 13
ParticipantIDs doaj_primary_oai_doaj_org_article_7594bdcc911a4e91a0867dfada1e33b8
crossref_primary_10_1080_0886022X_2021_1944875
crossref_citationtrail_10_1080_0886022X_2021_1944875
proquest_journals_2721097794
informaworld_taylorfrancis_310_1080_0886022X_2021_1944875
proquest_miscellaneous_2546980162
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8253186
PublicationCentury 2000
PublicationDate 2021-01-01
PublicationDateYYYYMMDD 2021-01-01
PublicationDate_xml – month: 01
  year: 2021
  text: 2021-01-01
  day: 01
PublicationDecade 2020
PublicationPlace New York
PublicationPlace_xml – name: New York
PublicationTitle Renal failure
PublicationYear 2021
Publisher Taylor & Francis
Taylor & Francis Ltd
Taylor & Francis Group
Publisher_xml – name: Taylor & Francis
– name: Taylor & Francis Ltd
– name: Taylor & Francis Group
References Long C (CIT0034) 2008; 26
Marzocco S (CIT0058) 2018; 7
CIT0030
CIT0032
CIT0031
CIT0033
Lin B (CIT0029) 2014; 15
Lappan R (CIT0053) 2019; 13
CIT0036
Remedios C (CIT0002) 2012; 22
CIT0038
CIT0037
CIT0041
CIT0040
Guo B (CIT0055) 2019; 14
CIT0001
CIT0045
Liu F (CIT0039) 2017; 44
Chen X (CIT0059) 2020; 8
Chang H (CIT0005) 2001; 28
CIT0003
CIT0047
CIT0049
CIT0004
CIT0048
CIT0007
Martin R (CIT0042) 2012; 50
CIT0009
CIT0008
CIT0050
CIT0052
Conen D (CIT0006) 2004; 4
CIT0010
CIT0054
CIT0012
CIT0056
CIT0011
Sinclair S (CIT0019) 2013; 171
CIT0014
Vaziri N (CIT0046) 1985; 80
CIT0057
CIT0016
CIT0015
CIT0018
CIT0017
CIT0061
CIT0060
CIT0063
CIT0062
CIT0021
CIT0065
CIT0020
Wexler A (CIT0043) 2017; 2
CIT0064
CIT0023
CIT0067
CIT0066
Huang G (CIT0022) 2017; 63
Armani R (CIT0013) 2017; 19
Itoh Y (CIT0051) 2012; 403
Guirong Y (CIT0044) 2018; 38
CIT0025
CIT0069
CIT0024
CIT0068
CIT0027
CIT0026
Amat N (CIT0035) 2015; 15
CIT0028
References_xml – ident: CIT0037
  doi: 10.1080/13880209.2020.1809462
– ident: CIT0065
  doi: 10.1128/CVI.13.2.219-226.2006
– ident: CIT0027
  doi: 10.1186/gb-2011-12-6-r60
– ident: CIT0069
  doi: 10.1007/s00467-016-3527-x
– volume: 8
  start-page: 299
  year: 2020
  ident: CIT0059
  publication-title: Front Bioeng Biotechnol
  doi: 10.3389/fbioe.2020.00299
– ident: CIT0010
  doi: 10.1007/s00424-020-02352-x
– ident: CIT0015
  doi: 10.1111/bcpt.12817
– ident: CIT0028
  doi: 10.1126/science.1171700
– volume: 44
  start-page: 401
  issue: 1
  year: 2017
  ident: CIT0039
  publication-title: Cell Physiol Biochem
  doi: 10.1159/000484920
– ident: CIT0014
  doi: 10.3390/toxins10070298
– ident: CIT0031
  doi: 10.1038/nature04516
– ident: CIT0045
  doi: 10.1159/000450619
– ident: CIT0050
  doi: 10.1016/j.cca.2013.02.008
– ident: CIT0063
  doi: 10.1038/s12276-019-0234-2
– ident: CIT0030
  doi: 10.1186/s12891-019-2519-y
– volume: 80
  start-page: 608
  issue: 8
  year: 1985
  ident: CIT0046
  publication-title: Am J Gastroenterol
– ident: CIT0032
  doi: 10.1186/2047-783X-18-26
– volume: 38
  start-page: 1401
  issue: 12
  year: 2018
  ident: CIT0044
  publication-title: Nan Fang Yi Ke Da Xue Xue Bao
– volume: 14
  start-page: e0223445
  issue: 10
  year: 2019
  ident: CIT0055
  publication-title: PloS One
  doi: 10.1371/journal.pone.0223445
– ident: CIT0054
  doi: 10.1038/ki.2012.345
– volume: 15
  start-page: 36
  issue: 1
  year: 2014
  ident: CIT0029
  publication-title: BMC Nephrol
  doi: 10.1186/1471-2369-15-36
– ident: CIT0036
  doi: 10.1016/j.biocel.2018.01.001
– volume: 15
  start-page: 131
  year: 2015
  ident: CIT0035
  publication-title: BMC Complement Altern Med
  doi: 10.1186/s12906-015-0644-1
– ident: CIT0021
  doi: 10.1208/s12248-012-9432-8
– ident: CIT0017
  doi: 10.1111/1750-3841.13793
– ident: CIT0018
  doi: 10.1016/j.jhep.2015.04.018
– volume: 13
  start-page: e0007444
  issue: 9
  year: 2019
  ident: CIT0053
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0007444
– ident: CIT0024
  doi: 10.1097/MIB.0000000000000522
– ident: CIT0057
  doi: 10.1016/j.anaerobe.2013.06.012
– ident: CIT0008
  doi: 10.1038/nrgastro.2017.20
– ident: CIT0049
  doi: 10.1016/j.bpg.2003.10.003
– ident: CIT0056
  doi: 10.1038/s41598-017-02989-2
– ident: CIT0064
  doi: 10.1155/2015/505878
– volume: 28
  start-page: 1640
  issue: 7
  year: 2001
  ident: CIT0005
  publication-title: J Rheumatol
– ident: CIT0067
  doi: 10.1111/j.1365-2982.2012.01921.x
– ident: CIT0007
  doi: 10.1002/art.30520
– ident: CIT0048
  doi: 10.1073/pnas.0812874106
– ident: CIT0026
  doi: 10.1038/nmeth.2604
– ident: CIT0009
  doi: 10.1007/s12275-018-8049-8
– volume: 2
  start-page: 17026
  year: 2017
  ident: CIT0043
  publication-title: Nat Microbiol
  doi: 10.1038/nmicrobiol.2017.26
– ident: CIT0038
  doi: 10.1016/j.jnutbio.2020.108515
– ident: CIT0041
  doi: 10.1038/srep33052
– ident: CIT0052
  doi: 10.1093/ndt/gfq580
– volume: 22
  start-page: 945
  issue: 6
  year: 2012
  ident: CIT0002
  publication-title: Obes Surg
  doi: 10.1007/s11695-012-0655-7
– ident: CIT0016
  doi: 10.1186/1476-4598-10-12
– ident: CIT0066
  doi: 10.3109/09637486.2015.1064869
– volume: 50
  start-page: 227
  issue: 2
  year: 2012
  ident: CIT0042
  publication-title: Food Chem Toxicol
  doi: 10.1016/j.fct.2011.10.070
– volume: 63
  start-page: 20
  issue: 7
  year: 2017
  ident: CIT0022
  publication-title: Cell Mol Biol (Noisy-le-Grand)
  doi: 10.14715/cmb/2017.63.7.3
– volume: 19
  start-page: 29
  issue: 4
  year: 2017
  ident: CIT0013
  publication-title: Curr Hypertens Rep
  doi: 10.1007/s11906-017-0727-0
– ident: CIT0023
  doi: 10.1080/21688370.2018.1425085
– ident: CIT0012
  doi: 10.1093/ndt/gfu287
– volume: 403
  start-page: 1841
  issue: 7
  year: 2012
  ident: CIT0051
  publication-title: Anal Bioanal Chem
  doi: 10.1007/s00216-012-5929-3
– volume: 171
  start-page: 38
  issue: 1
  year: 2013
  ident: CIT0019
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2013.06.032
– ident: CIT0025
  doi: 10.1080/00365520701864627
– ident: CIT0033
  doi: 10.1155/2015/535686
– ident: CIT0068
  doi: 10.1016/j.biopha.2017.07.123
– volume: 7
  start-page: 315
  issue: 10
  year: 2018
  ident: CIT0058
  publication-title: JCM
  doi: 10.3390/jcm7100315
– volume: 4
  start-page: 4
  issue: 1
  year: 2004
  ident: CIT0006
  publication-title: BMC Public Health
  doi: 10.1186/1471-2458-4-9
– ident: CIT0004
  doi: 10.1042/CS20180563
– ident: CIT0020
  doi: 10.1016/j.redox.2013.09.003
– volume: 26
  start-page: 2326
  issue: 12
  year: 2008
  ident: CIT0034
  publication-title: J Hypertens
  doi: 10.1097/HJH.0b013e328312c8c1
– ident: CIT0047
  doi: 10.2215/CJN.03150318
– ident: CIT0003
  doi: 10.1016/j.jare.2016.11.004
– ident: CIT0001
  doi: 10.1053/j.ajkd.2017.12.009
– ident: CIT0040
  doi: 10.1007/978-0-387-46401-5_20
– ident: CIT0060
  doi: 10.1016/j.apsb.2019.10.007
– ident: CIT0062
  doi: 10.1007/s00018-019-03155-9
– ident: CIT0011
  doi: 10.1007/978-981-10-8684-7_9
– ident: CIT0061
  doi: 10.1016/bs.aambs.2016.06.002
SSID ssj0015872
Score 2.5037327
Snippet It is well known that the progression of hyperuricemia disease often contributes to renal dysfunction. However, there have been few studies on uric acid...
SourceID doaj
pubmedcentral
proquest
crossref
informaworld
SourceType Open Website
Open Access Repository
Aggregation Database
Enrichment Source
Index Database
Publisher
StartPage 1063
SubjectTerms Apoptosis
Creatinine
Curcumin
Digestive system
Endotoxemia
Fatty acids
Fibrosis
Gastrointestinal tract
Gut microbiota
Hyperuricemia
Inflammation
intestinal barrier
Intestinal microflora
Intestine
Laboratory Study
Metabolism
Microbiota
Nephropathy
Next-generation sequencing
Opportunist infection
Renal function
Uric acid
uric acid nephropathy
SummonAdditionalLinks – databaseName: ProQuest Central (subscription)
  dbid: BENPR
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Nb9QwELVgixAXvhGBgozENWWTOBv7hGjVigurCoG0t2CPnRKpmyz5QOLfM5M4y4YDPXCN48TRPNvPY-c9xt6mOgGnAEKT6CIUJlKhVksXGqFAOaciUcjBbCJbr-Vmoy59wq31xyqnMXEYqG0NlCN_F-NSZYlkRYn3ux8huUbR7qq30LjNjkipTCzY0en5-vLzfh8hlYN9E3YlOmobb6Z_eEhdW5L9UrzBNWIcnWBlMRw2PJidBhH_vyRMZ0R0fozyYF66ePC_X_SQ3feMlH8YIfSI3XLVY3b3k99zf8K-nfUN9Nuy4tvaktmXa_lV3_FtOWo4dZrryvJyyE5gWePocTRfUsw51kOQtZwSvpwkjLiG0vLK7cigAfnnr6fs68X5l7OPofdlCCFNVBcaE5nVCokGiChDRimVBYlMz8ZJISMNSFpclkibSu10kRpXZKsMoiUWxIgDkzxji6qu3HPGE-sUKcYDQCoEpAqhQWtAsBIhI0zAxBSPHLxoOXlnXOfRpG3qw5hTGHMfxoCd7KvtRtWOmyqcUrD3N5Po9nChbq5y34fzDJtnLADOD1ogjDUuBzNbaKsjlyRGBkwdQiXvhpxLMRqk5MkNDTieQJL7UaTN_yAkYG_2xdj_aVNHV67u8Z6UPECRuMcBy2Z4nH3MvKQqvw9K4jLGIViuXvz75S_ZPWrqmHg6Zouu6d0rdgd-dmXbvPZd7jfsnjMT
  priority: 102
  providerName: ProQuest
– databaseName: Taylor & Francis Journals Complete
  dbid: TFW
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQhRAX3ojQgozENWUTO4l9hIoVFyoORezN2GOnRGKz1SZB4t93JnFWDRLqAY6JM4kf45lvbOcbxt4WVkDQAKkTtk6ly3Rq9SqkTmrQIehM1mpMNlGdn6vNRn-Jpwm7eKySYuh6IooYbTVNbuu6-UTcO5wYJbqeDUZ3eXaKUTiBbrTC6Poph8HF-tthH6FQY_omkkhJZP6H529vWXinkcT_DwrTBRBdHqO84ZfWD_9Dix6xBxGU8veTFj1md0L7hN37HLfdn7LvZ8Mehm3T8u3OU76v0PHLoefbZqJx6i3HT_NmXKDAsn2g15HLpGHnKId61nFa8-XEYsQtNJ634YpyNCAE_f2MfV1_vDj7lMbUDCkUQvepc5krS8QaILMKQaXSHhSCPZ-LWmUWELeESihfKBtsXbhQV2UF2QoLclQFJ56zo3bXhheMCx80kcYDQCElFBq1g8JA8Aq1RrqEyXlIDETeckqf8dNkM71p7D1DvWdi7yXs9CB2NRF33Cbwgcb78DDxbo83dvtLE6exqbB6zgOgi7ASNdliRFj52nqbBSGcSpi-qS2mH5dd6ilHihG3VOBkVi0TDUlncozQV4jRtUzYm0MxmgDa17Ft2A34TEFpQBG75wmrFiq5aMyypG1-jGTiKkcrrMqX_1DxY3afLqeFqRN21O-H8IrdhV990-1fjxPyGhAzNFg
  priority: 102
  providerName: Taylor & Francis
Title Curcumin modulates gut microbiota and improves renal function in rats with uric acid nephropathy
URI https://www.tandfonline.com/doi/abs/10.1080/0886022X.2021.1944875
https://www.proquest.com/docview/2721097794
https://www.proquest.com/docview/2546980162
https://pubmed.ncbi.nlm.nih.gov/PMC8253186
https://doaj.org/article/7594bdcc911a4e91a0867dfada1e33b8
Volume 43
WOSCitedRecordID wos000668370900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 1525-6049
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0015872
  issn: 0886-022X
  databaseCode: DOA
  dateStart: 20160101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1525-6049
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0015872
  issn: 0886-022X
  databaseCode: 7X7
  dateStart: 20171101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1525-6049
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0015872
  issn: 0886-022X
  databaseCode: BENPR
  dateStart: 20171101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Publicly Available Content Database
  customDbUrl:
  eissn: 1525-6049
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0015872
  issn: 0886-022X
  databaseCode: PIMPY
  dateStart: 20171101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Research Library
  customDbUrl:
  eissn: 1525-6049
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0015872
  issn: 0886-022X
  databaseCode: M2O
  dateStart: 20171101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/pqrl
  providerName: ProQuest
– providerCode: PRVAWR
  databaseName: Taylor & Francis Journals Complete
  customDbUrl:
  eissn: 1525-6049
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0015872
  issn: 0886-022X
  databaseCode: TFW
  dateStart: 20170101
  isFulltext: true
  titleUrlDefault: https://www.tandfonline.com
  providerName: Taylor & Francis
– providerCode: PRVAWR
  databaseName: Taylor & Francis Open Access
  customDbUrl:
  eissn: 1525-6049
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0015872
  issn: 0886-022X
  databaseCode: 0YH
  dateStart: 19870101
  isFulltext: true
  titleUrlDefault: https://www.tandfonline.com
  providerName: Taylor & Francis
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nj9MwELVgQYgL4lMElspIXLM0iVPbR3a11XJoqdAisifjryyRaLpqEyT-PTNOUjVceuFiKXEcxZmZ-I3tvEfIh1xn1ktrY5PpMmYmkbGWUx8bJq30XiasFEFsgi-Xoijk6kDqC_eEdfTA3Yv7yHPJjLMWglIzaKsBg3NXaqcTn2Um_OYLqGdIpvr1g1wE2SYIIdximxbDvzvIqi1QdiktIDdMkzPI4VnYZHgwKgXy_n-oS0cAdLx98mA8mj8lT3ogST91HXhG7vn6OXm06JfKX5AfF-3WtuuqpuuNQ40uv6O3bUPXVUe91Giqa0erMKkAdVuPt8NhDk1FoR34xo7iPC1F5iGqbeVo7e9QVwFg45-X5Nv88vriKu7lFGKbZ7KJjUnMbAb4wLKEAxAU0lkBAM2lWSkSbQFreJ4JlwvtdZkbX_IZt8kUKlIwn8lekZN6U_vXhGbOSyR6t9bmjFkwUSkwdbNOgKWZiQgbXqeyPdc4Sl78UslASdpbQaEVVG-FiJztm911ZBvHGpyjrfYXI1d2OAEepHoPUsc8KCLy0NKqCVMlZadrorIjD3A6uIXqg3-nUsiqp4CrJYvI-301hC2uxejab1q4JkfpTsDbaUT4yJ1GnRnX1NXPQAAOWT18imdv_kfv35LH2KFuVumUnDTb1r8jD-3vptptJ-T-9OYKSl7wUIoJeXB-uVx9nYR4g3KRfoFzq8-L1Q0cXc-__wUpDSx7
linkProvider Directory of Open Access Journals
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB6VgoALb9RAgUWCo9vYXse7B4SgULVqG3EoUm7bfblYapyQ2KD-KX4jM36EmAM99cA1693s2t88PZ4P4E2iY-ultYGJdRZwE8pAy6EPDJdWei9DnomabCIdj8VkIr9swK_uWxgqq-x0Yq2o3cxSjnw3wlBliM6K5O_n3wNijaK3qx2FRgOLI3_5E0O25bvDT_h830bR_ufTvYOgZRUIbBLLMjAmNKMRmknLwxT9ISGdFeinuCjORKgtmlyfxsIlQnudJcZn6Si14RAHIjyFiXHdG3AT9XhKJWTpZBXg4Vo1WRQKLhX2RpPuiyHq5S2I7CmaYEQahTuh5LwubVyzhTVlwF8NU3tub79oc80K7t__3-7fA7jX-tvsQyMgD2HDF4_g9klbUfAYzvaqha2mecGmM0dUZn7JzquSTfOmQ1WpmS4cy-vcC44tPC1H3gAhmuE8FKElo3Q2owZNTNvcscLPiX4CvevLJ_D1Ws73FDaLWeG3gMXOS-qHb61NOLeJROBThGudQIHgZgC8e_7Kti3ZiRnkQoVd59YWNopgo1rYDGBnNW3e9CS5asJHAtfqYmopXv8wW5yrVkOpFLdnnLVo_TRHIdUY7KYu006HPo6NGIBch6Yq64xS1tC_qPiKDWx3oFStjlyqP4gcwOvVMGo3emWlCz-r8JqEGE4xLIkGkPbw3ztMf6TIv9V90kWEBkaMnv37z1_BnYPTk2N1fDg-eg53adtNim0bNstF5V_ALfujzJeLl7WwMzi7bun4DfCVjb0
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagoIoLb0SggJG4pmxiJ7GPUFiBgFUPRezN-JU2Eptd5YHEv2cmcVYNEuoBrpmM48fY843tfEPIq0wz66W1sWG6jLlJZKzlwseGSyu9lwkvxZBsolitxHotT8NtwjZcq8QYuhyJIoa1Gif3zpXTjbjXMDFycD1riO7S5BiicATd18kNgM45xl9ny2_7g4RMDPmbUCVGneknnr8VM3NPA4v_HxymMyQ6v0d5yTEt7_yHJt0ltwMqpW9GM7pHrvn6Pjn8Es7dH5DvJ31j-01V083WYcIv39LzvqObauRx6jSFT9Nq2KEAWeOxOPSZOO4U9MDQWoqbvhRpjKi2laO132GSBsCgvx6Sr8v3Zycf4pCbIbYZk11sTGLyHMCG5UkBqFJIZwWgPZeyUiTaAnDxBRMuE9rrMjO-LPLCJgsQpGALhj0iB_W29o8JZc5LZI231mac20yCeWAcaJ0As-EmInwaEmUDcTnmz_ihkonfNPSewt5TofcicrxX243MHVcpvMXx3r-MxNvDg21zrsI8VgVUzzhrwUdoDqasISQsXKmdTjxjRkREXrYW1Q37LuWYJEWxKypwNJmWCitJq1II0RcA0iWPyMu9GNYAPNjRtd_28E6GeUABvKcRKWYmOWvMXFJXFwObuEhhGRb5k3-o-AtyePpuqT5_XH16Sm6hZNykOiIHXdP7Z-Sm_dlVbfN8mJu_AZzGNzQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Curcumin+modulates+gut+microbiota+and+improves+renal+function+in+rats+with+uric+acid+nephropathy&rft.jtitle=Renal+failure&rft.au=Xu%2C+Xueling&rft.au=Wang%2C+Huifang&rft.au=Guo%2C+Dandan&rft.au=Man%2C+Xiaofei&rft.date=2021-01-01&rft.issn=0886-022X&rft.eissn=1525-6049&rft.volume=43&rft.issue=1&rft.spage=1063&rft.epage=1075&rft_id=info:doi/10.1080%2F0886022X.2021.1944875&rft.externalDBID=n%2Fa&rft.externalDocID=10_1080_0886022X_2021_1944875
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0886-022X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0886-022X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0886-022X&client=summon