Cryo-EM structures of the human volume-regulated anion channel LRRC8

Maintenance of cell volume against osmotic change is crucial for proper cell functions. Leucine-rich repeat-containing 8 proteins are anion-selective channels that extrude anions to decrease the cell volume on cellular swelling. Here, we present the structure of human leucine-rich repeat-containing...

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Vydáno v:	Nature structural & molecular biology Ročník 25; číslo 9; s. 797 - 804
Hlavní autoři:	Kasuya, Go, Nakane, Takanori, Yokoyama, Takeshi, Jia, Yanyan, Inoue, Masato, Watanabe, Kengo, Nakamura, Ryoki, Nishizawa, Tomohiro, Kusakizako, Tsukasa, Tsutsumi, Akihisa, Yanagisawa, Haruaki, Dohmae, Naoshi, Hattori, Motoyuki, Ichijo, Hidenori, Yan, Zhiqiang, Kikkawa, Masahide, Shirouzu, Mikako, Ishitani, Ryuichiro, Nureki, Osamu
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Nature Publishing Group 01.09.2018
Témata:	Anions Cell size Cellular structure Electron microscopy Ion channels Ions Leucine Permeability Proteins Rigid-body dynamics Topology
ISSN:	1545-9993, 1545-9985, 1545-9985
On-line přístup:	Získat plný text
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