DNA repair dysregulation from cancer driver to therapeutic target

Key Points The DNA damage response (DDR) coordinates the repair of DNA and the activation of cell cycle checkpoints to arrest the cell to allow time for repair. DNA is subject to a high level of endogenous damage and the DDR is essential for the maintenance of genomic stability and survival. Dysregu...

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Bibliographic Details
Published in:	Nature reviews. Cancer Vol. 12; no. 12; pp. 801 - 817
Main Author:	Curtin, Nicola J.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.12.2012 Nature Publishing Group
Subjects:	631/337/1427/2566 692/699/67/1059/602 Analysis Animals Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Biomarkers - analysis Biomedical and Life Sciences Biomedicine Cancer Cancer Research Care and treatment Cell cycle Cell Cycle Checkpoints - genetics Cell survival Cellular signal transduction Chemotherapy Development and progression DNA Damage DNA repair DNA Repair - drug effects Genetic aspects Genomics Homologous Recombination Humans Neoplasms - drug therapy Neoplasms - genetics Physiological aspects Radiotherapy review-article Signal transduction Signal Transduction - genetics Stress Therapeutic applications
ISSN:	1474-175X, 1474-1768, 1474-1768
Online Access:	Get full text
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