DNA repair dysregulation from cancer driver to therapeutic target

Key Points The DNA damage response (DDR) coordinates the repair of DNA and the activation of cell cycle checkpoints to arrest the cell to allow time for repair. DNA is subject to a high level of endogenous damage and the DDR is essential for the maintenance of genomic stability and survival. Dysregu...

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Vydané v:	Nature reviews. Cancer Ročník 12; číslo 12; s. 801 - 817
Hlavný autor:	Curtin, Nicola J.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 01.12.2012 Nature Publishing Group
Predmet:	631/337/1427/2566 692/699/67/1059/602 Analysis Animals Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Biomarkers - analysis Biomedical and Life Sciences Biomedicine Cancer Cancer Research Care and treatment Cell cycle Cell Cycle Checkpoints - genetics Cell survival Cellular signal transduction Chemotherapy Development and progression DNA Damage DNA repair DNA Repair - drug effects Genetic aspects Genomics Homologous Recombination Humans Neoplasms - drug therapy Neoplasms - genetics Physiological aspects Radiotherapy review-article Signal transduction Signal Transduction - genetics Stress Therapeutic applications
ISSN:	1474-175X, 1474-1768, 1474-1768
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