Timing of Antiretroviral Therapy for HIV-1 Infection and Tuberculosis

In this international study involving 809 patients with HIV and TB coinfection, earlier therapy for both infections, versus waiting 8 to 12 weeks to initiate antiretrovirals after anti-TB therapy, was beneficial in patients with a low CD4+ T-cell count (<50 per cubic millimeter). The treatment of...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 365; no. 16; pp. 1482 - 1491
Main Authors:	Havlir, Diane V, Kendall, Michelle A, Ive, Prudence, Kumwenda, Johnstone, Swindells, Susan, Qasba, Sarojini S, Luetkemeyer, Anne F, Hogg, Evelyn, Rooney, James F, Wu, Xingye, Hosseinipour, Mina C, Lalloo, Umesh, Veloso, Valdilea G, Some, Fatuma F, Kumarasamy, N, Padayatchi, Nesri, Santos, Breno R, Reid, Stewart, Hakim, James, Mohapi, Lerato, Mugyenyi, Peter, Sanchez, Alejandro, Sanchez, Jorge, Lama, Javier R, Pape, Jean W, Asmelash, Aida, Moko, Evans, Sawe, Fred, Andersen, Janet, Sanne, Ian
Format:	Journal Article
Language:	English
Published:	Waltham, MA Massachusetts Medical Society 20.10.2011
Subjects:	Acquired immune deficiency syndrome Adult AIDS AIDS-Related Opportunistic Infections - drug therapy Anti-Retroviral Agents - administration & dosage Anti-Retroviral Agents - adverse effects Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral drugs Antiretroviral therapy Antitubercular Agents - therapeutic use Antiviral agents Biological and medical sciences CD4 antigen CD4 Lymphocyte Count Drug Administration Schedule Female General aspects HIV HIV Infections - complications HIV Infections - drug therapy HIV Infections - mortality HIV-1 Human immunodeficiency virus Human viral diseases Humans Immune reconstitution Infectious diseases Inflammation Kaplan-Meier Estimate Laboratories Lymphocytes T Male Medical sciences Mortality Patients Pharmacology. Drug treatments Ribonucleic acid RNA Tuberculosis Tuberculosis - complications Tuberculosis - drug therapy Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids United States > US San Francisco California Immunopathology Antiretroviral agent HIV-1 virus Retroviridae AIDS Mycobacterial infection Immune deficiency Lentivirus Infection Virus Medicine Chemotherapy Treatment Tuberculosis Viral disease Bacteriosis Temporal study Antiviral Human immunodeficiency virus Timing
ISSN:	0028-4793, 1533-4406, 1533-4406
Online Access:	Get full text
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