Development of a general method for designing microvascular networks using distribution of wall shear stress

In the present study, theoretical formulations for calculation of optimal bifurcation angle and relationship between the diameters of mother and daughter vessels using the power law model for non-Newtonian fluids are developed. The method is based on the distribution of wall shear stress in the moth...

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Vydáno v:Journal of biomechanics Ročník 46; číslo 13; s. 2303 - 2309
Hlavní autoři: Sayed Razavi, Mohammad, Shirani, Ebrahim
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Ltd 03.09.2013
Elsevier Limited
Témata:
Arterial bifurcation
Asymmetry
Behavior
Blood Flow Velocity
Computer Simulation
Coronary vessels
Flow pattern
Flow velocity
Microvascular systems
Microvessels - physiology
Models, Cardiovascular
Murray law
Physical Medicine and Rehabilitation
Rheology
Stress, Mechanical
Studies
Tissue engineering
Viscosity
Wall shear stress
Arterial bifurcation
Microvascular systems
Flow pattern
Wall shear stress
Murray law
ISSN:0021-9290, 1873-2380, 1873-2380
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Shrnutí:In the present study, theoretical formulations for calculation of optimal bifurcation angle and relationship between the diameters of mother and daughter vessels using the power law model for non-Newtonian fluids are developed. The method is based on the distribution of wall shear stress in the mother and daughter vessels. Also, the effect of distribution of wall shear stress on the minimization of energy loss and flow resistance is considered. It is shown that constant wall shear stress in the mother and daughter vessels provides the minimum flow resistance and energy loss of biological flows. Moreover, the effects of different wall shear stresses in the mother and daughter branches, different lengths of daughter branches in the asymmetric bifurcations and non-Newtonian effect of biological fluid flows on the bifurcation angle and the relationship between the diameters of mother and daughter branches are considered. Using numerical simulations for non-Newtonian models such as power law and Carreau models, the effects of optimal bifurcation angle on the pressure drop and flow resistance of blood flow in the symmetric bifurcation are investigated. Numerical simulations show that optimal bifurcation angle decreases the pressure drop and flow resistance especially for bifurcations at large Reynolds number.
Bibliografie:ObjectType-Article-1
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ISSN:0021-9290
1873-2380
1873-2380
DOI:10.1016/j.jbiomech.2013.06.005