Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons

Major depressive disorder (MDD) has an enormous impact on global disease burden, affecting millions of people worldwide and ranking as a leading cause of disability for almost three decades. Past molecular studies of MDD employed bulk homogenates of postmortem brain tissue, which obscures gene expre...

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Bibliographic Details
Published in:	Nature neuroscience Vol. 23; no. 6; pp. 771 - 781
Main Authors:	Nagy, Corina, Maitra, Malosree, Tanti, Arnaud, Suderman, Matthew, Théroux, Jean-Francois, Davoli, Maria Antonietta, Perlman, Kelly, Yerko, Volodymyr, Wang, Yu Chang, Tripathy, Shreejoy J, Pavlidis, Paul, Mechawar, Naguib, Ragoussis, Jiannis, Turecki, Gustavo
Format:	Journal Article
Language:	English
Published:	United States Nature Publishing Group 01.06.2020
Subjects:	Adolescent Adult Aged Aged, 80 and over Brain Case-Control Studies Depressive Disorder, Major - metabolism Gene expression Gene Regulatory Networks Glial stem cells High-Throughput Nucleotide Sequencing - methods Hormones Humans Immune response Male Mental depression Middle Aged Neurons Neurons - metabolism Nuclei (cytology) Oligodendrocyte Precursor Cells - metabolism Oligodendrocytes Precursors Prefrontal cortex Prefrontal Cortex - metabolism Steroid hormones Steroids Synaptic plasticity Transcriptome Young Adult
ISSN:	1097-6256, 1546-1726, 1546-1726
Online Access:	Get full text
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