A virophage at the origin of large DNA transposons
DNA transposons are mobile genetic elements that have shaped the genomes of eukaryotes for millions of years, yet their origins remain obscure. We discovered a virophage that, on the basis of genetic homology, likely represents an evolutionary link between double-stranded DNA viruses and Maverick/Po...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) Jg. 332; H. 6026; S. 231 |
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08.04.2011
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| Abstract | DNA transposons are mobile genetic elements that have shaped the genomes of eukaryotes for millions of years, yet their origins remain obscure. We discovered a virophage that, on the basis of genetic homology, likely represents an evolutionary link between double-stranded DNA viruses and Maverick/Polinton eukaryotic DNA transposons. The Mavirus virophage parasitizes the giant Cafeteria roenbergensis virus and encodes 20 predicted proteins, including a retroviral integrase and a protein-primed DNA polymerase B. On the basis of our data, we conclude that Maverick/Polinton transposons may have originated from ancient relatives of Mavirus, and thereby influenced the evolution of eukaryotic genomes, although we cannot rule out alternative evolutionary scenarios. |
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| AbstractList | DNA transposons are mobile genetic elements that have shaped the genomes of eukaryotes for millions of years, yet their origins remain obscure. We discovered a virophage that, on the basis of genetic homology, likely represents an evolutionary link between double-stranded DNA viruses and Maverick/Polinton eukaryotic DNA transposons. The Mavirus virophage parasitizes the giant Cafeteria roenbergensis virus and encodes 20 predicted proteins, including a retroviral integrase and a protein-primed DNA polymerase B. On the basis of our data, we conclude that Maverick/Polinton transposons may have originated from ancient relatives of Mavirus, and thereby influenced the evolution of eukaryotic genomes, although we cannot rule out alternative evolutionary scenarios.DNA transposons are mobile genetic elements that have shaped the genomes of eukaryotes for millions of years, yet their origins remain obscure. We discovered a virophage that, on the basis of genetic homology, likely represents an evolutionary link between double-stranded DNA viruses and Maverick/Polinton eukaryotic DNA transposons. The Mavirus virophage parasitizes the giant Cafeteria roenbergensis virus and encodes 20 predicted proteins, including a retroviral integrase and a protein-primed DNA polymerase B. On the basis of our data, we conclude that Maverick/Polinton transposons may have originated from ancient relatives of Mavirus, and thereby influenced the evolution of eukaryotic genomes, although we cannot rule out alternative evolutionary scenarios. DNA transposons are mobile genetic elements that have shaped the genomes of eukaryotes for millions of years, yet their origins remain obscure. We discovered a virophage that, on the basis of genetic homology, likely represents an evolutionary link between double-stranded DNA viruses and Maverick/Polinton eukaryotic DNA transposons. The Mavirus virophage parasitizes the giant Cafeteria roenbergensis virus and encodes 20 predicted proteins, including a retroviral integrase and a protein-primed DNA polymerase B. On the basis of our data, we conclude that Maverick/Polinton transposons may have originated from ancient relatives of Mavirus, and thereby influenced the evolution of eukaryotic genomes, although we cannot rule out alternative evolutionary scenarios. |
| Author | Suttle, Curtis A Fischer, Matthias G |
| Author_xml | – sequence: 1 givenname: Matthias G surname: Fischer fullname: Fischer, Matthias G organization: Department of Microbiology and Immunology, 1365-2350 Health Sciences Mall, University of British Columbia, Vancouver V6T 1Z3, Canada – sequence: 2 givenname: Curtis A surname: Suttle fullname: Suttle, Curtis A |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21385722$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Amino Acid Sequence DNA Transposable Elements DNA Viruses - genetics DNA Viruses - physiology DNA, Viral - genetics DNA-Directed DNA Polymerase - genetics Evolution, Molecular Genome, Viral Integrases - chemistry Integrases - genetics Molecular Sequence Data Phylogeny Satellite Viruses - genetics Satellite Viruses - physiology Stramenopiles - virology Viral Proteins - chemistry Viral Proteins - genetics Virus Replication |
| Title | A virophage at the origin of large DNA transposons |
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