Clonal Architecture of Secondary Acute Myeloid Leukemia

Whole-genome sequencing of samples from seven subjects with secondary acute myeloid leukemia identified somatic mutations. These data, together with genotype analysis of the antecedent myelodysplastic syndromes (MDS), revealed the clonal evolution of MDS and secondary AML. The myelodysplastic syndro...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 366; no. 12; pp. 1090 - 1098
Main Authors:	Walter, Matthew J, Shen, Dong, Ding, Li, Shao, Jin, Koboldt, Daniel C, Chen, Ken, Larson, David E, McLellan, Michael D, Dooling, David, Abbott, Rachel, Fulton, Robert, Magrini, Vincent, Schmidt, Heather, Kalicki-Veizer, Joelle, O'Laughlin, Michelle, Fan, Xian, Grillot, Marcus, Witowski, Sarah, Heath, Sharon, Frater, John L, Eades, William, Tomasson, Michael, Westervelt, Peter, DiPersio, John F, Link, Daniel C, Mardis, Elaine R, Ley, Timothy J, Wilson, Richard K, Graubert, Timothy A
Format:	Journal Article
Language:	English
Published:	Waltham, MA Massachusetts Medical Society 22.03.2012
Subjects:	Acute myeloid leukemia Adolescent Adult Biological and medical sciences Bone marrow Bone Marrow Cells - pathology Cancer Cell Transformation, Neoplastic - genetics Clonal selection Clone Cells Cloning Deoxyribonucleic acid Disease DNA Gene expression General aspects Genome, Human Genomes Hematologic and hematopoietic diseases Hematological diseases Humans Leukemia Leukemia, Myeloid, Acute - etiology Leukemia, Myeloid, Acute - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Middle Aged Mutation Myelodysplastic syndrome Myelodysplastic Syndromes - complications Myelodysplastic Syndromes - genetics Myeloid leukemia Oligonucleotide Array Sequence Analysis Pathogenesis Skin Young Adult Medicine Acute myelogenous leukemia Secondary Malignant hemopathy Architecture Cancer
ISSN:	0028-4793, 1533-4406, 1533-4406
Online Access:	Get full text
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