Thyroidal and Extrathyroidal Requirements for Iodine and Selenium: A Combined Evolutionary and (Patho)Physiological Approach

Iodide is an antioxidant, oxidant and thyroid hormone constituent. Selenoproteins are needed for triiodothyronine synthesis, its deactivation and iodine release. They also protect thyroidal and extrathyroidal tissues from hydrogen peroxide used in the ‘peroxidase partner system’. This system produce...

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Bibliographic Details
Published in:Nutrients Vol. 14; no. 19; p. 3886
Main Authors: Dijck-Brouwer, D. A. Janneke, Muskiet, Frits A. J., Verheesen, Richard H., Schaafsma, Gertjan, Schaafsma, Anne, Geurts, Jan M. W.
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 20.09.2022
MDPI
Subjects:
Antioxidants
Cancer
Diet
Exocrine glands
Hashimoto Disease
Health aspects
Hormones
Humans
Hydrogen Peroxide
Iodides
Iodine
Iodine in the body
Male
Metabolism
Oxidants
Oxidation
Peroxidases
Physiological aspects
Physiology
Prevention
Proteins
Recommended daily allowances
Review
Risk factors
Seawater
Selenium
Selenoproteins
Sulfur
Thyroid diseases
Thyroid gland
Thyroid Hormones
Thyroid Neoplasms
Toxicity
Triiodothyronine
Netherlands
autoimmune thyroid disease
peroxidase partner system
seafood
selenium
thyroid
exocrine glands
cancer
iodine
evolution
dietary reference intakes
ISSN:2072-6643, 2072-6643
Online Access:Get full text
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Summary:Iodide is an antioxidant, oxidant and thyroid hormone constituent. Selenoproteins are needed for triiodothyronine synthesis, its deactivation and iodine release. They also protect thyroidal and extrathyroidal tissues from hydrogen peroxide used in the ‘peroxidase partner system’. This system produces thyroid hormone and reactive iodine in exocrine glands to kill microbes. Exocrine glands recycle iodine and with high urinary clearance require constant dietary supply, unlike the thyroid. Disbalanced iodine-selenium explains relations between thyroid autoimmune disease (TAD) and cancer of thyroid and exocrine organs, notably stomach, breast, and prostate. Seafood is iodine unconstrained, but selenium constrained. Terrestrial food contains little iodine while selenium ranges from highly deficient to highly toxic. Iodine vs. TAD is U-shaped, but only low selenium relates to TAD. Oxidative stress from low selenium, and infection from disbalanced iodine-selenium, may generate cancer of thyroid and exocrine glands. Traditional Japanese diet resembles our ancient seashore-based diet and relates to aforementioned diseases. Adequate iodine might be in the milligram range but is toxic at low selenium. Optimal selenoprotein-P at 105 µg selenium/day agrees with Japanese intakes. Selenium upper limit may remain at 300–400 µg/day. Seafood combines iodine, selenium and other critical nutrients. It brings us back to the seashore diet that made us what we currently still are.
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ISSN:2072-6643
2072-6643
DOI:10.3390/nu14193886