Visual evoked potentials and MBP gene expression imply endogenous myelin repair in adult rat optic nerve and chiasm following local lysolecithin induced demyelination

Multiple sclerosis (MS) patients may suffer from optic disturbances. Toxin-induced demyelinations have frequently been developed to investigate the cellular and structural aspects of demyelination and remyelination processes, separately. The present study describes functional consequence of lysoleci...

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Published in:Brain research Vol. 1351; pp. 50 - 56
Main Authors: Mozafari, Sabah, Sherafat, Mohammad Amin, Javan, Mohammad, Mirnajafi-Zadeh, Javad, Tiraihi, Taki
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 10.09.2010
Elsevier
Subjects:
Age Factors
Animals
Biological and medical sciences
Demyelinating Diseases - chemically induced
Demyelinating Diseases - metabolism
Demyelinating Diseases - pathology
Evoked Potentials, Visual - drug effects
Evoked Potentials, Visual - physiology
Eye and associated structures. Visual pathways and centers. Vision
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation
Lysophosphatidylcholines - toxicity
Medical sciences
Multiple sclerosis (MS)
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Myelin Basic Protein - biosynthesis
Myelin Basic Protein - genetics
Myelin repair
Myelin Sheath - metabolism
Myelin Sheath - pathology
Neurology
Optic Chiasm - drug effects
Optic Chiasm - metabolism
Optic Chiasm - pathology
Optic Nerve - drug effects
Optic Nerve - metabolism
Optic Nerve - pathology
Rat optic chiasm and nerves
Rats
Rats, Sprague-Dawley
Transcription Factors - biosynthesis
Transcription Factors - genetics
Vertebrates: nervous system and sense organs
Visual evoked potential (VEP)
Myelin repair
Visual evoked potential (VEP)
Multiple sclerosis (MS)
Rat optic chiasm and nerves
Nervous system diseases
Multiple sclerosis
Optic nerve
Rat
Myelin
Rodentia
Electrophysiology
Visual evoked potential
Gene expression
Optic chiasma
Inflammatory disease
Vertebrata
Mammalia
Visual pathway
Demyelination
Central nervous system disease
Adult animal
Repair
ISSN:0006-8993, 1872-6240, 1872-6240
Online Access:Get full text
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Summary:Multiple sclerosis (MS) patients may suffer from optic disturbances. Toxin-induced demyelinations have frequently been developed to investigate the cellular and structural aspects of demyelination and remyelination processes, separately. The present study describes functional consequence of lysolecithin (LPC)-induced lesion in the adult rat optic nerves and chiasm by recording the visual evoked potentials (VEPs) from the visual cortex and its correlation with myelin basic protein (MBP) expression in lesion site. Records of VEP were obtained at 2, 7, 14 and 28days post-injection. We observed that the VEPs generated by light stimuli progressively changed in both amplitude and latency after the lesion as well as in comparison with those generated in control animals. These observations were confirmed through measurement of mRNA expression level for MBP which is one of the important genes expressed in mature oligodendrocytes and Schwann cells. The level of MBP mRNAs in demyelinated chiasm and optic nerves decreased following lysolecithin injection with its least value on day 7, and then it increased to the control level 14days post-lesion. However, it continued to increase even after that and reached a maximum level 28days post lesion. Results of the present paper show that, LPC injection in the chiasm share functional and molecular alterations which are found in demyelinating disorders in both the optic nerves and chiasm and also these alterations were coming back to level of control animal on 28days post lesion, which is typically seen in myelin repair process. The present paper provides new insights into the experimental toxin-induced models that may be useful for evaluating the functional recovery of demyelinated optic nerves and chiasm following various repairing strategies. It also seems to be useful for studying the protective or remyelinating effects of different therapies in e.g. optic apparatus which is more affected by MS. ►Lysolecithin injection into the optic chiasm causes alterations in VEP records. ►VEP records confirmed endogenous myelin repair. Changes in ►VEP records are correlated with the expression of myelin basic protein. ►VEP records provide useful evaluating tool for the efficacy of myelin repair strategies.
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ISSN:0006-8993
1872-6240
1872-6240
DOI:10.1016/j.brainres.2010.07.026