Visual evoked potentials and MBP gene expression imply endogenous myelin repair in adult rat optic nerve and chiasm following local lysolecithin induced demyelination

Multiple sclerosis (MS) patients may suffer from optic disturbances. Toxin-induced demyelinations have frequently been developed to investigate the cellular and structural aspects of demyelination and remyelination processes, separately. The present study describes functional consequence of lysoleci...

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Vydáno v:	Brain research Ročník 1351; s. 50 - 56
Hlavní autoři:	Mozafari, Sabah, Sherafat, Mohammad Amin, Javan, Mohammad, Mirnajafi-Zadeh, Javad, Tiraihi, Taki
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Amsterdam Elsevier B.V 10.09.2010 Elsevier
Témata:	Age Factors Animals Biological and medical sciences Demyelinating Diseases - chemically induced Demyelinating Diseases - metabolism Demyelinating Diseases - pathology Evoked Potentials, Visual - drug effects Evoked Potentials, Visual - physiology Eye and associated structures. Visual pathways and centers. Vision Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation Lysophosphatidylcholines - toxicity Medical sciences Multiple sclerosis (MS) Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Myelin Basic Protein - biosynthesis Myelin Basic Protein - genetics Myelin repair Myelin Sheath - metabolism Myelin Sheath - pathology Neurology Optic Chiasm - drug effects Optic Chiasm - metabolism Optic Chiasm - pathology Optic Nerve - drug effects Optic Nerve - metabolism Optic Nerve - pathology Rat optic chiasm and nerves Rats Rats, Sprague-Dawley Transcription Factors - biosynthesis Transcription Factors - genetics Vertebrates: nervous system and sense organs Visual evoked potential (VEP) Myelin repair Visual evoked potential (VEP) Multiple sclerosis (MS) Rat optic chiasm and nerves Nervous system diseases Multiple sclerosis Optic nerve Rat Myelin Rodentia Electrophysiology Visual evoked potential Gene expression Optic chiasma Inflammatory disease Vertebrata Mammalia Visual pathway Demyelination Central nervous system disease Adult animal Repair
ISSN:	0006-8993, 1872-6240, 1872-6240
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Popis
Shrnutí:	Multiple sclerosis (MS) patients may suffer from optic disturbances. Toxin-induced demyelinations have frequently been developed to investigate the cellular and structural aspects of demyelination and remyelination processes, separately. The present study describes functional consequence of lysolecithin (LPC)-induced lesion in the adult rat optic nerves and chiasm by recording the visual evoked potentials (VEPs) from the visual cortex and its correlation with myelin basic protein (MBP) expression in lesion site. Records of VEP were obtained at 2, 7, 14 and 28days post-injection. We observed that the VEPs generated by light stimuli progressively changed in both amplitude and latency after the lesion as well as in comparison with those generated in control animals. These observations were confirmed through measurement of mRNA expression level for MBP which is one of the important genes expressed in mature oligodendrocytes and Schwann cells. The level of MBP mRNAs in demyelinated chiasm and optic nerves decreased following lysolecithin injection with its least value on day 7, and then it increased to the control level 14days post-lesion. However, it continued to increase even after that and reached a maximum level 28days post lesion. Results of the present paper show that, LPC injection in the chiasm share functional and molecular alterations which are found in demyelinating disorders in both the optic nerves and chiasm and also these alterations were coming back to level of control animal on 28days post lesion, which is typically seen in myelin repair process. The present paper provides new insights into the experimental toxin-induced models that may be useful for evaluating the functional recovery of demyelinated optic nerves and chiasm following various repairing strategies. It also seems to be useful for studying the protective or remyelinating effects of different therapies in e.g. optic apparatus which is more affected by MS. ►Lysolecithin injection into the optic chiasm causes alterations in VEP records. ►VEP records confirmed endogenous myelin repair. Changes in ►VEP records are correlated with the expression of myelin basic protein. ►VEP records provide useful evaluating tool for the efficacy of myelin repair strategies.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0006-8993 1872-6240 1872-6240
DOI:	10.1016/j.brainres.2010.07.026