Homologous recombination restarts blocked replication forks at the expense of genome rearrangements by template exchange

Template switching induced by stalled replication forks has recently been proposed to underlie complex genomic rearrangements. However, the resulting models are not supported by robust physical evidence. Here, we analyzed replication and recombination intermediates in a well-defined fission yeast sy...

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Vydáno v:	Molecular cell Ročník 39; číslo 3; s. 346
Hlavní autoři:	Lambert, Sarah, Mizuno, Ken'ichi, Blaisonneau, Joël, Martineau, Sylvain, Chanet, Roland, Fréon, Karine, Murray, Johanne M, Carr, Antony M, Baldacci, Giuseppe
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 13.08.2010
Témata:	DNA Helicases - genetics DNA Helicases - metabolism DNA Replication - physiology DNA, Fungal - biosynthesis DNA, Fungal - genetics Genome, Fungal - physiology Rad51 Recombinase - genetics Rad51 Recombinase - metabolism Rad52 DNA Repair and Recombination Protein - genetics Rad52 DNA Repair and Recombination Protein - metabolism Recombination, Genetic - physiology Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Schizosaccharomyces - genetics Schizosaccharomyces - metabolism Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism
ISSN:	1097-4164, 1097-4164
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