Localization of relaxin‐like gonad‐stimulating peptide expression in starfish reveals the gonoducts as a source for its role as a regulator of spawning

Oocyte maturation and gamete release (spawning) in starfish are triggered by relaxin‐like gonad‐stimulating peptide (RGP), a neuropeptide that was first isolated from the radial nerve cords of these animals. Hitherto, it has generally been assumed that the radial nerve cords are the source of RGP th...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Journal of Comparative Neurology Ročník 531; číslo 13; s. 1299 - 1316
Hlavní autori: Feng, Yuling, Piñon Gonzalez, Victor M., Lin, Ming, Egertová, Michaela, Mita, Masatoshi, Elphick, Maurice R.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Wiley 01.09.2023
Wiley Subscription Services, Inc
John Wiley and Sons Inc
Predmet:
Animals
Asterias
Asterias - metabolism
Body wall
echinoderm
Epithelium
gonadotropin
Gonadotropins
Gonads
Gonads - metabolism
Heart
Hybridization
Immunohistochemistry
Localization
neuropeptide
Neuropeptides
Neuropeptides - metabolism
Peptides
Pituitary (anterior)
Relaxin
Relaxin - chemistry
Relaxin - metabolism
Spawning
Starfish
Starfish - metabolism
Stomach
spawning
relaxin
starfish
echinoderm
neuropeptide
gonadotropin
ISSN:0021-9967, 1096-9861, 1096-9861
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:Oocyte maturation and gamete release (spawning) in starfish are triggered by relaxin‐like gonad‐stimulating peptide (RGP), a neuropeptide that was first isolated from the radial nerve cords of these animals. Hitherto, it has generally been assumed that the radial nerve cords are the source of RGP that triggers spawning physiologically. To investigate other sources of RGP, here we report the first comprehensive anatomical analysis of its expression, using both in situ hybridization and immunohistochemistry to map RGP precursor transcripts and RGP, respectively, in the starfish Asterias rubens. Cells expressing RGP precursor transcripts were revealed in the ectoneural epithelium of the radial nerve cords and circumoral nerve ring, arm tips, tube feet, cardiac stomach, pyloric stomach, and, most notably, gonoducts. Using specific antibodies to A. rubens RGP, immunostaining was revealed in cells and/or fibers in the ectoneural region of the radial nerve cords and circumoral nerve ring, tube feet, terminal tentacle and other arm tip‐associated structures, body wall, peristomial membrane, esophagus, cardiac stomach, pyloric stomach, pyloric caeca, and gonoducts. Our discovery that RGP is expressed in the gonoducts of A. rubens proximal to its gonadotropic site of action in the gonads is important because it provides a new perspective on how RGP may act as a gonadotropin in starfish. Thus, we hypothesize that it is the release of RGP from the gonoducts that triggers gamete maturation and spawning in starfish, while RGP produced in other parts of the body may regulate other physiological/behavioral processes. Oocyte maturation and release (spawning) in starfish are triggered by relaxin‐like gonad‐stimulating peptide (RGP), which exerts its effects by stimulating ovarian follicle cells to produce 1‐methyladenine. Here, we present evidence that gonoducts (Gd) located proximal to the ovaries (O) are the physiological source of RGP that triggers spawning in starfish.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0021-9967
1096-9861
1096-9861
DOI:10.1002/cne.25496