The UK Adult Twin Registry (TwinsUK Resource)

TwinsUK is a nation-wide registry of volunteer twins in the United Kingdom, with about 12,000 registered twins (83% female, equal number of monozygotic and dizygotic twins, predominantly middle-aged and older). Over the last 20 years, questionnaire and blood/urine/tissue samples have been collected...

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Vydáno v:Twin research and human genetics Ročník 16; číslo 1; s. 144
Hlavní autoři: Moayyeri, Alireza, Hammond, Christopher J, Hart, Deborah J, Spector, Timothy D
Médium: Journal Article
Jazyk:angličtina
Vydáno: England 01.02.2013
Témata:
Adolescent
Adult
Aged
Aged, 80 and over
Diseases in Twins - epidemiology
Diseases in Twins - genetics
Female
Genome-Wide Association Study
Humans
Longitudinal Studies
Male
Middle Aged
Registries
Twins - genetics
United Kingdom - epidemiology
Young Adult
ISSN:1832-4274
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Popis
Shrnutí:TwinsUK is a nation-wide registry of volunteer twins in the United Kingdom, with about 12,000 registered twins (83% female, equal number of monozygotic and dizygotic twins, predominantly middle-aged and older). Over the last 20 years, questionnaire and blood/urine/tissue samples have been collected on over 7,000 subjects, as well as three comprehensive phenotyping assessments in the clinical facilities of the Department of Twin Research and Genetic Epidemiology, King's College London. The primary focus of study has been the genetic basis of healthy aging process and complex diseases, including cardiovascular, metabolic, musculoskeletal, and ophthalmologic disorders. Alongside the detailed clinical, biochemical, behavioral, and socio-economic characterization of the study population, the major strength of TwinsUK is availability of several 'omics' technologies for the participants. These include genome-wide scans of single nucleotide variants, next-generation sequencing, exome sequencing, epigenetic markers (MeDIP sequencing), gene expression arrays and RNA sequencing, telomere length measures, metabolomic profiles, and gut flora microbiomics. The scientific community now can freely access parts of the phenotype data from the 'TwinsUK', and interested researchers are encouraged to contact us via our Web site (www.twinsuk.ac.uk) for future collaborations.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1832-4274
DOI:10.1017/thg.2012.89