Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism

Endometriosis is a heritable hormone-dependent gynecological disorder, associated with severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely unknown. Here we perform a meta-analysis of 11 genome-wide association case-control data sets, totalling 17,045 endometrio...

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Veröffentlicht in:	Nature communications Jg. 8; H. 1; S. 15539 - 12
Hauptverfasser:	Sapkota, Yadav, Steinthorsdottir, Valgerdur, Morris, Andrew P., Fassbender, Amelie, Rahmioglu, Nilufer, De Vivo, Immaculata, Buring, Julie E., Zhang, Futao, Edwards, Todd L., Jones, Sarah, O, Dorien, Peterse, Daniëlle, Rexrode, Kathryn M., Ridker, Paul M., Schork, Andrew J., MacGregor, Stuart, Martin, Nicholas G., Becker, Christian M., Adachi, Sosuke, Yoshihara, Kosuke, Enomoto, Takayuki, Takahashi, Atsushi, Kamatani, Yoichiro, Matsuda, Koichi, Kubo, Michiaki, Thorleifsson, Gudmar, Geirsson, Reynir T., Thorsteinsdottir, Unnur, Wallace, Leanne M., Yang, Jian, Velez Edwards, Digna R., Nyegaard, Mette, Low, Siew-Kee, Zondervan, Krina T., Missmer, Stacey A., D'Hooghe, Thomas, Montgomery, Grant W., Chasman, Daniel I., Stefansson, Kari, Tung, Joyce Y., Nyholt, Dale R.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 24.05.2017 Nature Publishing Group Nature Portfolio
Schlagworte:	38/47 45/43 631/208/205/2138 631/208/457/649 692/308/2056 692/499 Adult Aged Endometriosis Endometriosis - genetics Endometriosis - metabolism Epidemiology Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Female Fertility Genetic Loci - genetics Genetic Predisposition to Disease Genetics Genome-Wide Association Study Genomes Genotype Gonadal Steroid Hormones - metabolism Gynecology Health care Hospitals Humanities and Social Sciences Humans Meta-analysis Metabolic Networks and Pathways - genetics Metabolism Middle Aged multidisciplinary Obstetrics Polymorphism, Single Nucleotide Preventive medicine Public health R&D Research & development Science Science (multidisciplinary) Steroids United Kingdom > UK Queensland Australia United States > US Tennessee Japan California Iceland Nashville Tennessee Belgium Massachusetts Denmark Australia Aarhus Denmark
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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