Metal-organic frameworks for stimuli-responsive drug delivery

Metal-organic framework (MOF), a novel hybrid porous material which is composited by metal ions and organic linkers, has drawn increasing attention and became a promising material in the biomedical field owing to their unique properties including large pore volume, high surface area, tunable pore si...

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Bibliographic Details
Published in:Biomaterials Vol. 230; p. 119619
Main Authors: Wang, Ying, Yan, Jianhua, Wen, Nachuan, Xiong, Hongjie, Cai, Shundong, He, Qunye, Hu, Yaqin, Peng, Dongming, Liu, Zhenbao, Liu, Yanfei
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ltd 01.02.2020
Subjects:
coordination polymers
Drug delivery system
Drug Delivery Systems
Drug Liberation
Drug release mechanism
drugs
glucose
glutathione
hydrogen sulfide
metal ions
Metal-organic framework
Metal-Organic Frameworks
Pharmaceutical Preparations
Porosity
porous media
Stimuli-responsive
surface area
temperature
Stimuli-responsive
Metal-organic framework
Drug delivery system
Drug release mechanism
ISSN:0142-9612, 1878-5905, 1878-5905
Online Access:Get full text
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Summary:Metal-organic framework (MOF), a novel hybrid porous material which is composited by metal ions and organic linkers, has drawn increasing attention and became a promising material in the biomedical field owing to their unique properties including large pore volume, high surface area, tunable pore size, versatile functionality and high drug loading efficiency. However, the MOF families and members, and the drug release mechanisms in MOF-based stimuli-responsive drug delivery systems (DDSs) are rarely summarized. Here, we systematically classified the families of MOF and introduced some representative members in MOF families. Moreover, the underlying drug release mechanisms were interpreted according to endogenous stimuli (include pH, glutathione (GSH), adenosine-triphosphate (ATP), ion, glucose, enzyme, H2S, and etc.) and the exogenous stimuli (include light, temperature, pressure, and etc.). Furthermore, the remaining challenges and future directions of DDSs based on MOF are discussed and proposed. This review revealed the relationship between the structure and properties of MOF. A better understanding of these release mechanisms under different stimuli would benefit the designing of sophisticated DDSs based on the promising material of MOF. [Display omitted]
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ISSN:0142-9612
1878-5905
1878-5905
DOI:10.1016/j.biomaterials.2019.119619