Cholangiocarcinoma: Current Knowledge and New Developments

Cholangiocarcinoma (CCA) is the second most common primary malignancy. Although it is more common in Asia, its incidence in Europe and North America has significantly increased in recent decades. The prognosis of CCA is dismal. Surgery is the only potentially curative treatment, but the majority of...

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Vydané v:	Gut and liver Ročník 11; číslo 1; s. 13 - 26
Hlavný autor:	Blechacz, Boris
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Korea (South) Editorial Office of Gut and Liver 15.01.2017 Gastroenterology Council for Gut and Liver 거트앤리버 소화기연관학회협의회
Predmet:	Asia - epidemiology bile duct Bile Duct Neoplasms - diagnosis Bile Duct Neoplasms - epidemiology Bile Duct Neoplasms - pathology Bile Duct Neoplasms - therapy cancer Caroli Disease - epidemiology Chemoradiotherapy cholangiocarcinoma Cholangiocarcinoma - diagnosis Cholangiocarcinoma - epidemiology Cholangiocarcinoma - pathology Cholangiocarcinoma - therapy Cholangitis, Sclerosing - epidemiology Choledochal Cyst - epidemiology Diabetes Mellitus - epidemiology Hepatectomy Hepatitis B - epidemiology Hepatitis C - epidemiology hepatobiliary Humans Klatskin Tumor - diagnosis Klatskin Tumor - epidemiology Klatskin Tumor - pathology Klatskin Tumor - therapy Liver Cirrhosis - epidemiology Liver Diseases, Parasitic - epidemiology Liver Transplantation Neoadjuvant Therapy neoplasia Neoplasm Staging Obesity - epidemiology Prognosis Review Risk Factors 내과학 Hepatobiliary Neoplasia Bile duct Cholangiocarcinoma Cancer
ISSN:	1976-2283, 2005-1212
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Shrnutí:	Cholangiocarcinoma (CCA) is the second most common primary malignancy. Although it is more common in Asia, its incidence in Europe and North America has significantly increased in recent decades. The prognosis of CCA is dismal. Surgery is the only potentially curative treatment, but the majority of patients present with advanced stage disease, and recurrence after resection is common. Over the last two decades, our understanding of the molecular biology of this malignancy has increased tremendously, diagnostic techniques have evolved, and novel therapeutic approaches have been established. This review discusses the changing epidemiologic trends and provides an overview of newly identified etiologic risk factors for CCA. Furthermore, the molecular pathogenesis is discussed as well as the influence of etiology and biliary location on the mutational landscape of CCA. This review provides an overview of the diagnostic evaluation of CCA and its staging systems. Finally, new therapeutic options are critically reviewed, and future therapeutic strategies discussed.
Bibliografia:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 G704-SER000001589.2017.11.1.016
ISSN:	1976-2283 2005-1212
DOI:	10.5009/gnl15568