Cholangiocarcinoma: Current Knowledge and New Developments

Cholangiocarcinoma (CCA) is the second most common primary malignancy. Although it is more common in Asia, its incidence in Europe and North America has significantly increased in recent decades. The prognosis of CCA is dismal. Surgery is the only potentially curative treatment, but the majority of...

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Veröffentlicht in:Gut and liver Jg. 11; H. 1; S. 13 - 26
1. Verfasser: Blechacz, Boris
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Korea (South) Editorial Office of Gut and Liver 15.01.2017
Gastroenterology Council for Gut and Liver
거트앤리버 소화기연관학회협의회
Schlagworte:
Asia - epidemiology
bile duct
Bile Duct Neoplasms - diagnosis
Bile Duct Neoplasms - epidemiology
Bile Duct Neoplasms - pathology
Bile Duct Neoplasms - therapy
cancer
Caroli Disease - epidemiology
Chemoradiotherapy
cholangiocarcinoma
Cholangiocarcinoma - diagnosis
Cholangiocarcinoma - epidemiology
Cholangiocarcinoma - pathology
Cholangiocarcinoma - therapy
Cholangitis, Sclerosing - epidemiology
Choledochal Cyst - epidemiology
Diabetes Mellitus - epidemiology
Hepatectomy
Hepatitis B - epidemiology
Hepatitis C - epidemiology
hepatobiliary
Humans
Klatskin Tumor - diagnosis
Klatskin Tumor - epidemiology
Klatskin Tumor - pathology
Klatskin Tumor - therapy
Liver Cirrhosis - epidemiology
Liver Diseases, Parasitic - epidemiology
Liver Transplantation
Neoadjuvant Therapy
neoplasia
Neoplasm Staging
Obesity - epidemiology
Prognosis
Review
Risk Factors
내과학
Hepatobiliary
Neoplasia
Bile duct
Cholangiocarcinoma
Cancer
ISSN:1976-2283, 2005-1212
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:Cholangiocarcinoma (CCA) is the second most common primary malignancy. Although it is more common in Asia, its incidence in Europe and North America has significantly increased in recent decades. The prognosis of CCA is dismal. Surgery is the only potentially curative treatment, but the majority of patients present with advanced stage disease, and recurrence after resection is common. Over the last two decades, our understanding of the molecular biology of this malignancy has increased tremendously, diagnostic techniques have evolved, and novel therapeutic approaches have been established. This review discusses the changing epidemiologic trends and provides an overview of newly identified etiologic risk factors for CCA. Furthermore, the molecular pathogenesis is discussed as well as the influence of etiology and biliary location on the mutational landscape of CCA. This review provides an overview of the diagnostic evaluation of CCA and its staging systems. Finally, new therapeutic options are critically reviewed, and future therapeutic strategies discussed.
Bibliographie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
G704-SER000001589.2017.11.1.016
ISSN:1976-2283
2005-1212
DOI:10.5009/gnl15568