Meat and heterocyclic amine intake, smoking, NAT1 and NAT2 polymorphisms, and colorectal cancer risk in the multiethnic cohort study

N-acetyltransferases (NAT) 1 and 2 are polymorphic enzymes catalyzing the metabolic activation of heterocyclic amines. We investigated the modifying effects of NAT1 and NAT2 polymorphisms on the association of meat consumption, heterocyclic amine intake, and smoking with colorectal cancer risk. In t...

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Vydáno v:Cancer epidemiology, biomarkers & prevention Ročník 18; číslo 7; s. 2098
Hlavní autoři: Nöthlings, Ute, Yamamoto, Jennifer F, Wilkens, Lynne R, Murphy, Suzanne P, Park, Song-Yi, Henderson, Brian E, Kolonel, Laurence N, Le Marchand, Loïc
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.07.2009
Témata:
Aged
Arylamine N-Acetyltransferase - genetics
Arylamine N-Acetyltransferase - metabolism
Case-Control Studies
Cohort Studies
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - genetics
Diet
Female
Hawaii - epidemiology
Heterocyclic Compounds - adverse effects
Heterocyclic Compounds - metabolism
Humans
Isoenzymes - genetics
Logistic Models
Los Angeles - epidemiology
Male
Meat
Middle Aged
Polymorphism, Single Nucleotide
Racial Groups
Risk Factors
Smoking - adverse effects
Surveys and Questionnaires
Hawaii
Los Angeles
ISSN:1538-7755, 1538-7755
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Shrnutí:N-acetyltransferases (NAT) 1 and 2 are polymorphic enzymes catalyzing the metabolic activation of heterocyclic amines. We investigated the modifying effects of NAT1 and NAT2 polymorphisms on the association of meat consumption, heterocyclic amine intake, and smoking with colorectal cancer risk. In the Multiethnic Cohort study, participants completed a smoking history and a food-frequency questionnaire at recruitment and a cooked meat module 5 years later to estimate heterocyclic amine intake (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline). Blood samples were collected from incident cases and age-, sex-, ethnicity-, frequency-matched controls to determine genotypes. For analysis of meat intake and smoking, data were available for 1,009 cases and 1,522 controls; for heterocyclic amine intake analyses, 398 cases and 1,444 controls were available. Multivariate logistic regression models were used to estimate odds ratios. Smoking was associated with an increased colorectal cancer risk (odds ratio, 1.51; 95% confidence interval, 1.17-1.95) for > or =30 pack-years compared with never smokers (P trend = 0.0004). The association was stronger with presence of the "rapid" compared with the "slow/intermediate" NAT2 genotype (P interaction = 0.003). No significant associations were observed for intakes of red meat, processed meat, and heterocyclic amine, or meat doneness preference, but a dietary pattern high in meat showed a weak positive interaction with the NAT2 genotype (P interaction = 0.05). The enhanced association between smoking and colorectal cancer risk in subjects with the NAT2 rapid genotype supports a role for NAT2 and tobacco smoke heterocyclic amines in the etiology of colorectal cancer. This study only provides weak support for a similar association with meat heterocyclic amines.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1538-7755
1538-7755
DOI:10.1158/1055-9965.EPI-08-1218