Mycobacterium tuberculosis: here today, and here tomorrow

Key Points Pathogenic Mycobacterium spp. survive within the macrophages of their host. One of these, Mycobacterium tuberculosis , is a highly successful pathogen that subverts two pathways of its host. First, it stops the normal progression of the phagosome into an acidic, hydrolytically active comp...

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Veröffentlicht in:	Nature reviews. Molecular cell biology Jg. 2; H. 8; S. 569 - 578
1. Verfasser:	Russell, David G.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.08.2001 Nature Publishing Group
Schlagworte:	Adult Animals Antitubercular Agents - therapeutic use Bacteria Bacterial infections BCG Vaccine Biochemistry Biology Biomedical and Life Sciences Biosynthesis Calmodulin - physiology Cancer Research Carrier Proteins - physiology Cation Transport Proteins Cations - metabolism Cell Biology Child Developmental Biology Drug Design Endosomes - microbiology Endosomes - physiology Gram-positive bacteria Granulomas HLA-D Antigens - immunology Humans Hydrogen-Ion Concentration Immunology Infections Intracellular Membranes - physiology Ion Transport Isocitrate Lyase - deficiency Isocitrate Lyase - genetics Isocitrate Lyase - physiology Life Sciences Lipids - physiology Lysosomes - chemistry Macrophages, Alveolar - enzymology Macrophages, Alveolar - microbiology Macrophages, Alveolar - ultrastructure Membrane Fusion Membrane Proteins - physiology Mice Mice, Knockout Models, Biological Mycobacterium avium - physiology Mycobacterium avium-intracellulare Infection - immunology Mycobacterium avium-intracellulare Infection - microbiology Mycobacterium avium-intracellulare Infection - pathology Mycobacterium bovis - physiology Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - physiology Pathogens Phagosomes - microbiology Phagosomes - physiology Proteins review-article Stem Cells Transferrin - metabolism Tuberculosis Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - microbiology Tuberculosis, Pulmonary - pathology Vacuoles - microbiology
ISSN:	1471-0072, 1471-0080
Online-Zugang:	Volltext
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