Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

The safe and effective delivery of drugs is a major obstacle in the treatment of ischemic stroke. Exosomes hold great promise as an endogenous drug delivery nanosystem for the treatment of cerebral ischemia given their unique properties, including low immunogenicity, innate stability, high delivery...

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Vydané v:Biomaterials Ročník 150; s. 137 - 149
Hlavní autori: Tian, Tian, Zhang, Hui-Xin, He, Chun-Peng, Fan, Song, Zhu, Yan-Liang, Qi, Cui, Huang, Ning-Ping, Xiao, Zhong-Dang, Lu, Zu-Hong, Tannous, Bakhos A., Gao, Jun
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Netherlands Elsevier Ltd 01.01.2018
Predmet:
animal models
Animals
apoptosis
blood-brain barrier
brain
Cell Line, Tumor
Cerebral ischemia
chemistry
Curcumin
Curcumin - administration & dosage
Curcumin - chemistry
Disease Models, Animal
drug carriers
Drug delivery
drugs
Exosomes
Exosomes - chemistry
HeLa Cells
Humans
immune response
Infarction, Middle Cerebral Artery
inflammation
Injections, Intravenous
intravenous injection
ischemia
Male
Mice
Mice, Inbred C57BL
Peptides - administration & dosage
Peptides - chemistry
Pharmaceutical Vehicles
stroke
Stroke - drug therapy
Cerebral ischemia
Drug delivery
Curcumin
Exosomes
ISSN:0142-9612, 1878-5905, 1878-5905
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Shrnutí:The safe and effective delivery of drugs is a major obstacle in the treatment of ischemic stroke. Exosomes hold great promise as an endogenous drug delivery nanosystem for the treatment of cerebral ischemia given their unique properties, including low immunogenicity, innate stability, high delivery efficiency, and ability to cross the blood-brain barrier (BBB). However, exosome insufficient targeting capability limits their clinical applications. In this study, the c(RGDyK) peptide has been conjugated to the exosome surface by an easy, rapid, and bio-orthogonal chemistry. In the transient middle cerebral artery occlusion (MCAO) mice model, The engineered c(RGDyK)-conjugated exosomes (cRGD-Exo) target the lesion region of the ischemic brain after intravenous administration. Furthermore, curcumin has been loaded onto the cRGD-Exo, and administration of these exosomes has resulted in a strong suppression of the inflammatory response and cellular apoptosis in the lesion region. The results suggest a targeting delivery vehicle for ischemic brain based on exosomes and provide a strategy for the rapid and large-scale production of functionalized exosomes.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0142-9612
1878-5905
1878-5905
DOI:10.1016/j.biomaterials.2017.10.012