Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

The safe and effective delivery of drugs is a major obstacle in the treatment of ischemic stroke. Exosomes hold great promise as an endogenous drug delivery nanosystem for the treatment of cerebral ischemia given their unique properties, including low immunogenicity, innate stability, high delivery...

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Veröffentlicht in:	Biomaterials Jg. 150; S. 137 - 149
Hauptverfasser:	Tian, Tian, Zhang, Hui-Xin, He, Chun-Peng, Fan, Song, Zhu, Yan-Liang, Qi, Cui, Huang, Ning-Ping, Xiao, Zhong-Dang, Lu, Zu-Hong, Tannous, Bakhos A., Gao, Jun
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier Ltd 01.01.2018
Schlagworte:	animal models Animals apoptosis blood-brain barrier brain Cell Line, Tumor Cerebral ischemia chemistry Curcumin Curcumin - administration & dosage Curcumin - chemistry Disease Models, Animal drug carriers Drug delivery drugs Exosomes Exosomes - chemistry HeLa Cells Humans immune response Infarction, Middle Cerebral Artery inflammation Injections, Intravenous intravenous injection ischemia Male Mice Mice, Inbred C57BL Peptides - administration & dosage Peptides - chemistry Pharmaceutical Vehicles stroke Stroke - drug therapy Cerebral ischemia Drug delivery Curcumin Exosomes
ISSN:	0142-9612, 1878-5905, 1878-5905
Online-Zugang:	Volltext
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