Identification of unique and common low abundance tumour-specific transcripts by suppression subtractive hybridization and oligonucleotide probe array analysis

Most human cancers are characterized by genetic aberrations accompanied by altered expression and function of numerous genes. Applying genome-wide, microarray gene expression analysis to identify deregulated genes in different tumour types can provide potential gene candidates as diagnostic and prog...

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Bibliographic Details
Published in:	Oncogene Vol. 27; no. 29; pp. 4128 - 4136
Main Authors:	Liu, B H, Goh, C H K, Ooi, L L P J, Hui, K M
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 03.07.2008 Nature Publishing Nature Publishing Group
Subjects:	Abundance Antisense RNA Antisense therapy Apoptosis Biological and medical sciences Biopsy Breast cancer Breast carcinoma Cancer Care and treatment Cell Biology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Deoxyribonucleic acid DNA DNA microarrays DNA Probes - genetics DNA, Complementary DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Drug development Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene expression Gene Expression Profiling - methods Genes, Neoplasm Genetic aspects Genomics Genomics - methods Gynecology. Andrology. Obstetrics Hepatocellular carcinoma Human Genetics Humans Hybridization Internal Medicine Liver cancer Liver. Biliary tract. Portal circulation. Exocrine pancreas Mammary gland diseases Medical diagnosis Medical sciences Medicine Medicine & Public Health Methods Molecular and cellular biology Nasopharyngeal carcinoma Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Nucleic acid hybridization Oligonucleotide Array Sequence Analysis - methods Oligonucleotides oncogenomics Oncology Research methodology Ribonucleic acid Risk factors RNA RNA, Neoplasm - biosynthesis RNA, Neoplasm - genetics Throat cancer Transcription, Genetic Tumors Singapore breast cancer affymetrix GeneChip arrays nasopharyngeal carcinoma suppression subtractive hybridization hepatocellular carcinoma low abundance transcripts Breast disease Suppression Hepatic disease Hepatocellular carcinoma Breast cancer Identification Malignant tumor Nasopharynx carcinoma Gene expression Carcinogenesis Mammary gland diseases ENT disease Digestive diseases Pharynx disease Oligonucleotide Cancer
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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