NANOG and LIN28 dramatically improve human cell reprogramming by modulating LIN41 and canonical WNT activities

Human cell reprogramming remains extremely inefficient and the underlying mechanisms by different reprogramming factors are elusive. We found that NANOG and LIN28 (NL) synergize to improve OCT4, SOX2, KLF4 and MYC (OSKM)-mediated reprogramming by ∼76-fold and shorten reprogramming latency by at leas...

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Veröffentlicht in:	Biology open Jg. 8; H. 12
Hauptverfasser:	Wang, Ling, Su, Yue, Huang, Chang, Yin, Yexuan, Chu, Alexander, Knupp, Alec, Tang, Young
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England The Company of Biologists Ltd 05.12.2019 The Company of Biologists
Schlagworte:	Cell activation Colonies Efficiency epithelialization Gene expression Histone methyltransferase induced pluripotent stem cell (ipsc) Inhibitory postsynaptic potentials Kinetics KLF4 protein Latency lin28 lin41 miRNA Mutation Myc protein Oct-4 protein reprogramming efficiency Signaling Stem cells Synergism wnt Wnt protein β-Catenin Induced pluripotent stem cell (iPSC) Epithelialization WNT LIN28 Reprogramming efficiency LIN41
ISSN:	2046-6390, 2046-6390
Online-Zugang:	Volltext
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