Activation‐induced deaminase–deficient MRL/lpr mice secrete high levels of protective antibodies against lupus nephritis

Objective We previously generated MRL/lpr mice deficient in activation‐induced deaminase (AID) that lack isotype switching and immunoglobulin hypermutation. These mice have high levels of unmutated (germline) autoreactive IgM, yet they experienced an increase in survival and an improvement in lupus...

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Veröffentlicht in:	Arthritis & Rheumatism Jg. 63; H. 4; S. 1086 - 1096
Hauptverfasser:	Jiang, Chuancang, Zhao, Ming‐Lang, Scearce, Richard M., Diaz, Marilyn
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2011 Wiley Wiley Subscription Services, Inc
Schlagworte:	AICDA (Activation-Induced Cytidine Deaminase) Animals Antibodies - metabolism Apoptosis - drug effects Apoptosis - physiology B-Lymphocytes - immunology B-Lymphocytes - metabolism Biological and medical sciences Cytidine Deaminase - deficiency Cytidine Deaminase - genetics Cytidine Deaminase - metabolism Disease Models, Animal Diseases of the osteoarticular system DNA - immunology Hybridomas - immunology Hybridomas - metabolism Immunoglobulin M - metabolism Immunoglobulin M - pharmacology Kidney - immunology Kidney - pathology Kidneys Lupus Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - metabolism Lupus Nephritis - metabolism Lupus Nephritis - pathology Lupus Nephritis - prevention & control Medical research Medical sciences Mice Mice, Inbred C57BL Mice, Inbred MRL lpr Mice, Knockout Nephrology. Urinary tract diseases Proteinuria - metabolism Rodents Urinary system involvement in other diseases. Miscellaneous Kidney disease Immunopathology Connective tissue disease Skin disease Urinary system disease Antibody Rodentia Rheumatology Autoimmune disease Activation Lupus nephritis Prevention Vertebrata Mammalia Mouse Animal Systemic disease
ISSN:	0004-3591, 1529-0131, 1529-0131
Online-Zugang:	Volltext
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