Use of high-fat diets to study rodent obesity as a model of human obesity

At present there is a range of commercial high-fat diets available that have been demonstrated to make small rodents obese. However, some of these diets contain levels of dietary fat that are much higher than the levels that humans routinely consume. The question has been raised as to whether experi...

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Bibliographic Details
Published in:International Journal of Obesity Vol. 43; no. 8; pp. 1491 - 1492
Main Author: Speakman, John R
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.08.2019
Subjects:
Animal models
Animals
Diet
Diet, High-Fat
Disease Models, Animal
High fat diet
Humans
Mice
Obesity
Rodentia
Rodents
Studies
ISSN:0307-0565, 1476-5497, 1476-5497
Online Access:Get full text
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Summary:At present there is a range of commercial high-fat diets available that have been demonstrated to make small rodents obese. However, some of these diets contain levels of dietary fat that are much higher than the levels that humans routinely consume. The question has been raised as to whether experimental use of these diets with very high levels of fat adequately models the situation of human obesity.
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ISSN:0307-0565
1476-5497
1476-5497
DOI:10.1038/s41366-019-0363-7