Pulse pressure variation shows a direct linear correlation with tidal volume in anesthetized healthy patients

Background The settings of mechanical ventilation, like tidal volume (VT), occasionally need to be adjusted in the process of anesthesia for some special reasons. The aim of this study was therefore to assess the relationship between pulse pressure variations (PPVs) in different settings of VT in an...

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Vydané v:BMC anesthesiology Ročník 16; číslo 1; s. 75
Hlavní autori: Liu, Yi, Lou, Jing-sheng, Mi, Wei-dong, Yuan, Wei-xiu, Fu, Qiang, Wang, Min, Qu, Jing
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London BioMed Central 08.09.2016
BioMed Central Ltd
Springer Nature B.V
Predmet:
Adolescent
Adult
Anesthesia
Anesthesia, General
Anesthesiology
Blood Pressure - physiology
Critical Care Medicine
Emergency Medicine
Female
Healthy Volunteers
Humans
Intensive
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Perioperative medicine and outcome
Prospective Studies
Pulse
Research Article
Respiration, Artificial
Statistics as Topic
Therapeutics, Experimental
Tidal Volume - physiology
Young Adult
Blood pressure
Volume
Mechanical ventilation
Pulse pressure variation
Tidal volume
ISSN:1471-2253, 1471-2253
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Shrnutí:Background The settings of mechanical ventilation, like tidal volume (VT), occasionally need to be adjusted in the process of anesthesia for some special reasons. The aim of this study was therefore to assess the relationship between pulse pressure variations (PPVs) in different settings of VT in anesthetized healthy patients under mechanical ventilation. Methods Sixty nine ASA I-II patients scheduled for gastrointestinal surgery under general anesthesia were included in this prospective study. All the patients were ventilated at a VT of 6, 8 or 10 ml/kg (predicted body weight) with no positive end expiratory pressure (PEEP) in a random order after intubation. PPV, mean arterial blood pressure, and other hemodynamic and respiratory parameters were recorded in each VT setting respectively after Partial Pressure of End-Tidal Expiration Carbon Dioxide (PetCO 2 ) maintained between 30 mmHg and 40 mmHg by changing Respiratory Rate (RR) before incision. Results The values of PPV at different settings of VT showed a tight correlation between each other (6 vs. 8 ml/kg: r  = 0.97, P  < 0.0001; 6 vs.10 ml/kg: r  = 0.95, P  < 0.0001; 8 vs. 10 ml/kg: r  = 0.98, P  < 0.0001, respectively). Conclusion There is a direct linear correlation between PPVs at different tidal volumes in anesthetized ASA I-II patients. PPV in any of the 3 VT settings (6, 8 or 10 ml/kg) can deduce that in any other 2 settings. Further studies are needed to explore the effect of intraoperative confounders for this knowledge to be clinically applied. Trial registration NCT01950949 , www.clinicaltrials.gov , July 26, 2013.
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ISSN:1471-2253
1471-2253
DOI:10.1186/s12871-016-0233-y