Pulse pressure variation shows a direct linear correlation with tidal volume in anesthetized healthy patients
Background The settings of mechanical ventilation, like tidal volume (VT), occasionally need to be adjusted in the process of anesthesia for some special reasons. The aim of this study was therefore to assess the relationship between pulse pressure variations (PPVs) in different settings of VT in an...
Uloženo v:
| Vydáno v: | BMC anesthesiology Ročník 16; číslo 1; s. 75 |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
London
BioMed Central
08.09.2016
BioMed Central Ltd Springer Nature B.V |
| Témata: | |
| ISSN: | 1471-2253, 1471-2253 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Background
The settings of mechanical ventilation, like tidal volume (VT), occasionally need to be adjusted in the process of anesthesia for some special reasons. The aim of this study was therefore to assess the relationship between pulse pressure variations (PPVs) in different settings of VT in anesthetized healthy patients under mechanical ventilation.
Methods
Sixty nine ASA I-II patients scheduled for gastrointestinal surgery under general anesthesia were included in this prospective study. All the patients were ventilated at a VT of 6, 8 or 10 ml/kg (predicted body weight) with no positive end expiratory pressure (PEEP) in a random order after intubation. PPV, mean arterial blood pressure, and other hemodynamic and respiratory parameters were recorded in each VT setting respectively after Partial Pressure of End-Tidal Expiration Carbon Dioxide (PetCO
2
) maintained between 30 mmHg and 40 mmHg by changing Respiratory Rate (RR) before incision.
Results
The values of PPV at different settings of VT showed a tight correlation between each other (6 vs. 8 ml/kg:
r
= 0.97,
P
< 0.0001; 6 vs.10 ml/kg:
r
= 0.95,
P
< 0.0001; 8 vs. 10 ml/kg:
r
= 0.98,
P
< 0.0001, respectively).
Conclusion
There is a direct linear correlation between PPVs at different tidal volumes in anesthetized ASA I-II patients. PPV in any of the 3 VT settings (6, 8 or 10 ml/kg) can deduce that in any other 2 settings. Further studies are needed to explore the effect of intraoperative confounders for this knowledge to be clinically applied.
Trial registration
NCT01950949
,
www.clinicaltrials.gov
, July 26, 2013. |
|---|---|
| AbstractList | Background
The settings of mechanical ventilation, like tidal volume (VT), occasionally need to be adjusted in the process of anesthesia for some special reasons. The aim of this study was therefore to assess the relationship between pulse pressure variations (PPVs) in different settings of VT in anesthetized healthy patients under mechanical ventilation.
Methods
Sixty nine ASA I-II patients scheduled for gastrointestinal surgery under general anesthesia were included in this prospective study. All the patients were ventilated at a VT of 6, 8 or 10 ml/kg (predicted body weight) with no positive end expiratory pressure (PEEP) in a random order after intubation. PPV, mean arterial blood pressure, and other hemodynamic and respiratory parameters were recorded in each VT setting respectively after Partial Pressure of End-Tidal Expiration Carbon Dioxide (PetCO
2
) maintained between 30 mmHg and 40 mmHg by changing Respiratory Rate (RR) before incision.
Results
The values of PPV at different settings of VT showed a tight correlation between each other (6 vs. 8 ml/kg:
r
= 0.97,
P
< 0.0001; 6 vs.10 ml/kg:
r
= 0.95,
P
< 0.0001; 8 vs. 10 ml/kg:
r
= 0.98,
P
< 0.0001, respectively).
Conclusion
There is a direct linear correlation between PPVs at different tidal volumes in anesthetized ASA I-II patients. PPV in any of the 3 VT settings (6, 8 or 10 ml/kg) can deduce that in any other 2 settings. Further studies are needed to explore the effect of intraoperative confounders for this knowledge to be clinically applied.
Trial registration
NCT01950949
,
www.clinicaltrials.gov
, July 26, 2013. The settings of mechanical ventilation, like tidal volume (VT), occasionally need to be adjusted in the process of anesthesia for some special reasons. The aim of this study was therefore to assess the relationship between pulse pressure variations (PPVs) in different settings of VT in anesthetized healthy patients under mechanical ventilation.BACKGROUNDThe settings of mechanical ventilation, like tidal volume (VT), occasionally need to be adjusted in the process of anesthesia for some special reasons. The aim of this study was therefore to assess the relationship between pulse pressure variations (PPVs) in different settings of VT in anesthetized healthy patients under mechanical ventilation.Sixty nine ASA I-II patients scheduled for gastrointestinal surgery under general anesthesia were included in this prospective study. All the patients were ventilated at a VT of 6, 8 or 10 ml/kg (predicted body weight) with no positive end expiratory pressure (PEEP) in a random order after intubation. PPV, mean arterial blood pressure, and other hemodynamic and respiratory parameters were recorded in each VT setting respectively after Partial Pressure of End-Tidal Expiration Carbon Dioxide (PetCO2) maintained between 30 mmHg and 40 mmHg by changing Respiratory Rate (RR) before incision.METHODSSixty nine ASA I-II patients scheduled for gastrointestinal surgery under general anesthesia were included in this prospective study. All the patients were ventilated at a VT of 6, 8 or 10 ml/kg (predicted body weight) with no positive end expiratory pressure (PEEP) in a random order after intubation. PPV, mean arterial blood pressure, and other hemodynamic and respiratory parameters were recorded in each VT setting respectively after Partial Pressure of End-Tidal Expiration Carbon Dioxide (PetCO2) maintained between 30 mmHg and 40 mmHg by changing Respiratory Rate (RR) before incision.The values of PPV at different settings of VT showed a tight correlation between each other (6 vs. 8 ml/kg: r = 0.97, P < 0.0001; 6 vs.10 ml/kg: r = 0.95, P < 0.0001; 8 vs. 10 ml/kg: r = 0.98, P < 0.0001, respectively).RESULTSThe values of PPV at different settings of VT showed a tight correlation between each other (6 vs. 8 ml/kg: r = 0.97, P < 0.0001; 6 vs.10 ml/kg: r = 0.95, P < 0.0001; 8 vs. 10 ml/kg: r = 0.98, P < 0.0001, respectively).There is a direct linear correlation between PPVs at different tidal volumes in anesthetized ASA I-II patients. PPV in any of the 3 VT settings (6, 8 or 10 ml/kg) can deduce that in any other 2 settings. Further studies are needed to explore the effect of intraoperative confounders for this knowledge to be clinically applied.CONCLUSIONThere is a direct linear correlation between PPVs at different tidal volumes in anesthetized ASA I-II patients. PPV in any of the 3 VT settings (6, 8 or 10 ml/kg) can deduce that in any other 2 settings. Further studies are needed to explore the effect of intraoperative confounders for this knowledge to be clinically applied.NCT01950949 , www.clinicaltrials.gov , July 26, 2013.TRIAL REGISTRATIONNCT01950949 , www.clinicaltrials.gov , July 26, 2013. The settings of mechanical ventilation, like tidal volume (VT), occasionally need to be adjusted in the process of anesthesia for some special reasons. The aim of this study was therefore to assess the relationship between pulse pressure variations (PPVs) in different settings of VT in anesthetized healthy patients under mechanical ventilation. Sixty nine ASA I-II patients scheduled for gastrointestinal surgery under general anesthesia were included in this prospective study. All the patients were ventilated at a VT of 6, 8 or 10 ml/kg (predicted body weight) with no positive end expiratory pressure (PEEP) in a random order after intubation. PPV, mean arterial blood pressure, and other hemodynamic and respiratory parameters were recorded in each VT setting respectively after Partial Pressure of End-Tidal Expiration Carbon Dioxide (PetCO2) maintained between 30 mmHg and 40 mmHg by changing Respiratory Rate (RR) before incision. The values of PPV at different settings of VT showed a tight correlation between each other (6 vs. 8 ml/kg: r = 0.97, P < 0.0001; 6 vs.10 ml/kg: r = 0.95, P < 0.0001; 8 vs. 10 ml/kg: r = 0.98, P < 0.0001, respectively). There is a direct linear correlation between PPVs at different tidal volumes in anesthetized ASA I-II patients. PPV in any of the 3 VT settings (6, 8 or 10 ml/kg) can deduce that in any other 2 settings. Further studies are needed to explore the effect of intraoperative confounders for this knowledge to be clinically applied. NCT01950949 , www.clinicaltrials.gov , July 26, 2013. The settings of mechanical ventilation, like tidal volume (VT), occasionally need to be adjusted in the process of anesthesia for some special reasons. The aim of this study was therefore to assess the relationship between pulse pressure variations (PPVs) in different settings of VT in anesthetized healthy patients under mechanical ventilation. Sixty nine ASA I-II patients scheduled for gastrointestinal surgery under general anesthesia were included in this prospective study. All the patients were ventilated at a VT of 6, 8 or 10 ml/kg (predicted body weight) with no positive end expiratory pressure (PEEP) in a random order after intubation. PPV, mean arterial blood pressure, and other hemodynamic and respiratory parameters were recorded in each VT setting respectively after Partial Pressure of End-Tidal Expiration Carbon Dioxide (PetCO.sub.2) maintained between 30 mmHg and 40 mmHg by changing Respiratory Rate (RR) before incision. The values of PPV at different settings of VT showed a tight correlation between each other (6 vs. 8 ml/kg: r = 0.97, P < 0.0001; 6 vs.10 ml/kg: r = 0.95, P < 0.0001; 8 vs. 10 ml/kg: r = 0.98, P < 0.0001, respectively). There is a direct linear correlation between PPVs at different tidal volumes in anesthetized ASA I-II patients. PPV in any of the 3 VT settings (6, 8 or 10 ml/kg) can deduce that in any other 2 settings. Further studies are needed to explore the effect of intraoperative confounders for this knowledge to be clinically applied. Background The settings of mechanical ventilation, like tidal volume (VT), occasionally need to be adjusted in the process of anesthesia for some special reasons. The aim of this study was therefore to assess the relationship between pulse pressure variations (PPVs) in different settings of VT in anesthetized healthy patients under mechanical ventilation. Methods Sixty nine ASA I-II patients scheduled for gastrointestinal surgery under general anesthesia were included in this prospective study. All the patients were ventilated at a VT of 6, 8 or 10 ml/kg (predicted body weight) with no positive end expiratory pressure (PEEP) in a random order after intubation. PPV, mean arterial blood pressure, and other hemodynamic and respiratory parameters were recorded in each VT setting respectively after Partial Pressure of End-Tidal Expiration Carbon Dioxide (PetCO2) maintained between 30 mmHg and 40 mmHg by changing Respiratory Rate (RR) before incision. Results The values of PPV at different settings of VT showed a tight correlation between each other (6 vs. 8 ml/kg: r = 0.97, P < 0.0001; 6 vs.10 ml/kg: r = 0.95, P < 0.0001; 8 vs. 10 ml/kg: r = 0.98, P < 0.0001, respectively). Conclusion There is a direct linear correlation between PPVs at different tidal volumes in anesthetized ASA I-II patients. PPV in any of the 3 VT settings (6, 8 or 10 ml/kg) can deduce that in any other 2 settings. Further studies are needed to explore the effect of intraoperative confounders for this knowledge to be clinically applied. Background The settings of mechanical ventilation, like tidal volume (VT), occasionally need to be adjusted in the process of anesthesia for some special reasons. The aim of this study was therefore to assess the relationship between pulse pressure variations (PPVs) in different settings of VT in anesthetized healthy patients under mechanical ventilation. Methods Sixty nine ASA I-II patients scheduled for gastrointestinal surgery under general anesthesia were included in this prospective study. All the patients were ventilated at a VT of 6, 8 or 10 ml/kg (predicted body weight) with no positive end expiratory pressure (PEEP) in a random order after intubation. PPV, mean arterial blood pressure, and other hemodynamic and respiratory parameters were recorded in each VT setting respectively after Partial Pressure of End-Tidal Expiration Carbon Dioxide (PetCO.sub.2) maintained between 30 mmHg and 40 mmHg by changing Respiratory Rate (RR) before incision. Results The values of PPV at different settings of VT showed a tight correlation between each other (6 vs. 8 ml/kg: r = 0.97, P < 0.0001; 6 vs.10 ml/kg: r = 0.95, P < 0.0001; 8 vs. 10 ml/kg: r = 0.98, P < 0.0001, respectively). Conclusion There is a direct linear correlation between PPVs at different tidal volumes in anesthetized ASA I-II patients. PPV in any of the 3 VT settings (6, 8 or 10 ml/kg) can deduce that in any other 2 settings. Further studies are needed to explore the effect of intraoperative confounders for this knowledge to be clinically applied. Trial registration NCT01950949, www.clinicaltrials.gov, July 26, 2013. Keywords: Pulse pressure variation, Tidal volume, Blood pressure, Volume, Mechanical ventilation |
| ArticleNumber | 75 |
| Audience | Academic |
| Author | Qu, Jing Liu, Yi Lou, Jing-sheng Yuan, Wei-xiu Wang, Min Fu, Qiang Mi, Wei-dong |
| Author_xml | – sequence: 1 givenname: Yi surname: Liu fullname: Liu, Yi organization: Anesthesiology and Operation Center, Chinese PLA General Hospital – sequence: 2 givenname: Jing-sheng surname: Lou fullname: Lou, Jing-sheng organization: Anesthesiology and Operation Center, Chinese PLA General Hospital – sequence: 3 givenname: Wei-dong surname: Mi fullname: Mi, Wei-dong email: mwd1962@sina.cn organization: Anesthesiology and Operation Center, Chinese PLA General Hospital – sequence: 4 givenname: Wei-xiu surname: Yuan fullname: Yuan, Wei-xiu organization: Anesthesiology and Operation Center, Chinese PLA General Hospital – sequence: 5 givenname: Qiang surname: Fu fullname: Fu, Qiang organization: Anesthesiology and Operation Center, Chinese PLA General Hospital – sequence: 6 givenname: Min surname: Wang fullname: Wang, Min organization: Department of Anesthesiology, Beijing Tongren hospital, Capital Medical University – sequence: 7 givenname: Jing surname: Qu fullname: Qu, Jing organization: Graduate School, Xuzhou Medical College |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27609188$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kktv1DAUhSNURB_wA9ggS2zYpPgRJ54NUlXxkirBAtaWx76ZuHLswU6mmv567jAtTCtAXsRyvnOuzr33tDqKKUJVvWT0nDHVvi2Mq47VlLU15ULU2yfVCWvwhXMpjg7ux9VpKdeUsk5R8aw65l1LF0ypk2r8OocCZJ2hlDkD2ZjszeRTJGVIN4UY4nwGO5HgI5hMbMoZwp648dNAJu9MIJsU5hGIj8REKNMAk78FRwYwYRq2ZI0CiFN5Xj3tDdZ7cfc9q75_eP_t8lN99eXj58uLq9pK0U01LKRSbrlsgRnFKXWyp6J3IJnomOCCGweus7TlXbMUfS9VT23XtMJhK4A6cVa92_uu5-UIzmLtbIJeZz-avNXJeP3wT_SDXqWNltgiKiUavLkzyOnHjIn06IuFEDBemotmiikhukYIRF8_Qq_TnCPGQ6phikoumz_UygTQPvYJ69qdqb5oWtnyBWM7r_O_UHgcjN7i8HuP7w8Erw6D_k54P2AEuj1gcyolQ6-tn36ND5190Izq3Srp_Spp7J_erZLeopI9Ut6b_0_D95qCbFxBPujFP0U_AUMt3I8 |
| CitedBy_id | crossref_primary_10_1016_j_ajem_2018_08_037 crossref_primary_10_1016_j_jpeds_2021_04_012 crossref_primary_10_1007_s00101_025_01575_w crossref_primary_10_1016_j_cardfail_2018_05_003 crossref_primary_10_1007_s10877_017_0081_4 crossref_primary_10_1007_s10877_023_01090_6 crossref_primary_10_1097_ALN_0000000000005175 crossref_primary_10_1016_j_suc_2018_07_006 |
| Cites_doi | 10.1093/bja/aes398 10.7326/0003-4819-151-8-200910200-00011 10.1097/ALN.0000000000000754 10.1016/S0272-5231(05)70331-2 10.1093/bja/aep319 10.1007/s00134-005-2586-4 10.1016/S0140-6736(98)01134-9 10.1007/s00134-009-1478-4 10.1097/01.CCM.0000139761.05492.D6 10.1097/MCC.0000000000000044 10.1056/NEJM199802053380602 10.1111/j.1399-6576.2011.02641.x 10.1186/cc10222 10.1056/NEJMoa010307 10.1007/s00134-011-2304-3 10.1093/bja/aep123 10.1186/1471-2253-14-90 10.1056/NEJMoa1301082 10.1097/EJA.0b013e328319bf5e 10.1007/s00134-009-1686-y 10.1378/chest.88.5.653 10.1097/CCM.0b013e3181a590da 10.1111/j.1399-6576.2007.01432.x 10.1097/00000542-200610000-00013 10.1056/NEJM196311072691901 |
| ContentType | Journal Article |
| Copyright | The Author(s). 2016 COPYRIGHT 2016 BioMed Central Ltd. Copyright BioMed Central 2016 |
| Copyright_xml | – notice: The Author(s). 2016 – notice: COPYRIGHT 2016 BioMed Central Ltd. – notice: Copyright BioMed Central 2016 |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7TK 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S M1P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM |
| DOI | 10.1186/s12871-016-0233-y |
| DatabaseName | Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Neurosciences Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Medical Database ProQuest ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Neurosciences Abstracts ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1471-2253 |
| ExternalDocumentID | PMC5017055 4256534081 A465629113 27609188 10_1186_s12871_016_0233_y |
| Genre | Research Support, Non-U.S. Gov't Journal Article Observational Study |
| GrantInformation_xml | – fundername: Chinese PLA general hospital nursery fund of science and technology innovation grantid: 14KMM35 – fundername: ; grantid: 14KMM35 |
| GroupedDBID | --- 0R~ 23N 2WC 53G 5GY 5VS 6J9 6PF 7X7 88E 8FI 8FJ AAFWJ AAJSJ AASML AAWTL ABDBF ABUWG ACGFO ACGFS ACIHN ACPRK ACUHS ADBBV ADRAZ ADUKV AEAQA AENEX AFKRA AFPKN AFRAH AHBYD AHMBA AHSBF AHYZX ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIJS BAPOH BAWUL BCNDV BENPR BFQNJ BMC BPHCQ BVXVI C6C CCPQU CS3 DIK E3Z EBD EBLON EBS EJD ESX F5P FYUFA GROUPED_DOAJ GX1 H13 HMCUK HYE IAO IHR INH INR ITC KQ8 M1P M48 M~E O5R O5S OK1 OVT P2P PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQQKQ PROAC PSQYO PUEGO RBZ RNS ROL RPM RSV SMD SOJ TR2 TUS U2A UKHRP W2D WOQ WOW XSB ~8M AAYXX AFFHD CITATION -A0 3V. ACRMQ ADINQ ALIPV C24 CGR CUY CVF ECM EIF NPM 7TK 7XB 8FK AZQEC DWQXO K9. PKEHL PQEST PQUKI PRINS 7X8 5PM |
| ID | FETCH-LOGICAL-c537t-e9588dbb6e1a8200d5f03fde513713232aded7c06274b3ff58f0c7463d016e0d3 |
| IEDL.DBID | RSV |
| ISICitedReferencesCount | 10 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000383130700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1471-2253 |
| IngestDate | Tue Nov 04 01:33:34 EST 2025 Fri Sep 05 07:39:38 EDT 2025 Mon Oct 06 18:31:48 EDT 2025 Tue Nov 11 10:58:38 EST 2025 Tue Nov 04 18:16:50 EST 2025 Thu Jan 02 23:11:18 EST 2025 Sat Nov 29 05:41:01 EST 2025 Tue Nov 18 22:03:24 EST 2025 Sat Sep 06 07:28:50 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Blood pressure Volume Mechanical ventilation Pulse pressure variation Tidal volume |
| Language | English |
| License | Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c537t-e9588dbb6e1a8200d5f03fde513713232aded7c06274b3ff58f0c7463d016e0d3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 |
| OpenAccessLink | https://link.springer.com/10.1186/s12871-016-0233-y |
| PMID | 27609188 |
| PQID | 1841805254 |
| PQPubID | 44060 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_5017055 proquest_miscellaneous_1818337433 proquest_journals_1841805254 gale_infotracmisc_A465629113 gale_infotracacademiconefile_A465629113 pubmed_primary_27609188 crossref_citationtrail_10_1186_s12871_016_0233_y crossref_primary_10_1186_s12871_016_0233_y springer_journals_10_1186_s12871_016_0233_y |
| PublicationCentury | 2000 |
| PublicationDate | 2016-09-08 |
| PublicationDateYYYYMMDD | 2016-09-08 |
| PublicationDate_xml | – month: 09 year: 2016 text: 2016-09-08 day: 08 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationSubtitle | BMC series – open, inclusive and trusted |
| PublicationTitle | BMC anesthesiology |
| PublicationTitleAbbrev | BMC Anesthesiol |
| PublicationTitleAlternate | BMC Anesthesiol |
| PublicationYear | 2016 |
| Publisher | BioMed Central BioMed Central Ltd Springer Nature B.V |
| Publisher_xml | – name: BioMed Central – name: BioMed Central Ltd – name: Springer Nature B.V |
| References | F Bliacheriene (233_CR5) 2007; 51 F Vallee (233_CR8) 2009; 35 MB Amato (233_CR24) 1998; 338 F Jardin (233_CR16) 1985; 88 E Futier (233_CR27) 2013; 369 M Lavieren van (233_CR20) 2014; 14 J Mesquida (233_CR13) 2011; 37 JJ Marini (233_CR23) 1996; 17 A Serpa Neto (233_CR28) 2014; 20 SM Hollenberg (233_CR4) 2004; 32 C Putensen (233_CR11) 2009; 151 RD Miller (233_CR15) 2010 G Gouvea (233_CR18) 2009; 103 G Choi (233_CR10) 2006; 105 A Guldner (233_CR12) 2015; 123 RH Oliveira (233_CR21) 2009; 26 L Muller (233_CR9) 2010; 36 E Rivers (233_CR3) 2001; 345 PE Marik (233_CR6) 2009; 37 TN Weingarten (233_CR26) 2010; 104 ME Astiz (233_CR2) 1998; 351 D Backer De (233_CR7) 2005; 31 J Mallat (233_CR17) 2011; 15 HH Bendixen (233_CR22) 1963; 269 FG Freitas (233_CR14) 2013; 110 LO Hoiseth (233_CR19) 2012; 56 N Petrucci (233_CR25) 2003; 3 P Wang (233_CR1) 1992; 263 19347330 - Intensive Care Med. 2009 Jun;35(6):1004-10 17006066 - Anesthesiology. 2006 Oct;105(4):689-95 17714573 - Acta Anaesthesiol Scand. 2007 Oct;51(9):1268-72 19454548 - Br J Anaesth. 2009 Aug;103(2):238-43 15343024 - Crit Care Med. 2004 Sep;32(9):1928-48 19841457 - Ann Intern Med. 2009 Oct 20;151(8):566-76 11794169 - N Engl J Med. 2001 Nov 8;345(19):1368-77 19122555 - Eur J Anaesthesiol. 2009 Jan;26(1):66-72 19602972 - Crit Care Med. 2009 Sep;37(9):2642-7 25337036 - BMC Anesthesiol. 2014 Oct 14;14:90 24275571 - Curr Opin Crit Care. 2014 Feb;20(1):25-32 9449727 - N Engl J Med. 1998 Feb 5;338(6):347-54 1636714 - Am J Physiol. 1992 Jul;263(1 Pt 1):G38-43 21739340 - Intensive Care Med. 2011 Oct;37(10):1672-9 22288953 - Acta Anaesthesiol Scand. 2012 Jul;56(6):777-86 23902482 - N Engl J Med. 2013 Aug 1;369(5):428-37 3902386 - Chest. 1985 Nov;88(5):653-8 19933173 - Br J Anaesth. 2010 Jan;104(1):16-22 14059732 - N Engl J Med. 1963 Nov 7;269:991-6 12917991 - Cochrane Database Syst Rev. 2003;(3):CD003844 23161359 - Br J Anaesth. 2013 Mar;110(3):402-8 19847400 - Intensive Care Med. 2010 Mar;36(3):496-503 9605819 - Lancet. 1998 May 16;351(9114):1501-5 26120769 - Anesthesiology. 2015 Sep;123(3):692-713 15754196 - Intensive Care Med. 2005 Apr;31(4):517-23 21672281 - Crit Care. 2011;15(3):432; author reply 432 8875011 - Clin Chest Med. 1996 Sep;17(3):555-75 |
| References_xml | – volume: 110 start-page: 402 issue: 3 year: 2013 ident: 233_CR14 publication-title: Br J Anaesth doi: 10.1093/bja/aes398 – volume: 151 start-page: 566 issue: 8 year: 2009 ident: 233_CR11 publication-title: Ann Intern Med doi: 10.7326/0003-4819-151-8-200910200-00011 – volume: 123 start-page: 692 issue: 3 year: 2015 ident: 233_CR12 publication-title: Anesthesiology doi: 10.1097/ALN.0000000000000754 – volume: 17 start-page: 555 issue: 3 year: 1996 ident: 233_CR23 publication-title: Clin Chest Med doi: 10.1016/S0272-5231(05)70331-2 – volume: 104 start-page: 16 issue: 1 year: 2010 ident: 233_CR26 publication-title: Br J Anaesth doi: 10.1093/bja/aep319 – volume: 3 year: 2003 ident: 233_CR25 publication-title: Cochrane Database Syst Rev – volume: 31 start-page: 517 issue: 4 year: 2005 ident: 233_CR7 publication-title: Intensive Care Med doi: 10.1007/s00134-005-2586-4 – volume: 351 start-page: 1501 issue: 9114 year: 1998 ident: 233_CR2 publication-title: Lancet doi: 10.1016/S0140-6736(98)01134-9 – volume: 35 start-page: 1004 issue: 6 year: 2009 ident: 233_CR8 publication-title: Intensive Care Med doi: 10.1007/s00134-009-1478-4 – volume: 263 start-page: G38 issue: 1 Pt 1 year: 1992 ident: 233_CR1 publication-title: Am J Physiol – volume: 32 start-page: 1928 issue: 9 year: 2004 ident: 233_CR4 publication-title: Crit Care Med doi: 10.1097/01.CCM.0000139761.05492.D6 – volume: 20 start-page: 25 issue: 1 year: 2014 ident: 233_CR28 publication-title: Curr Opin Crit Care doi: 10.1097/MCC.0000000000000044 – volume: 338 start-page: 347 issue: 6 year: 1998 ident: 233_CR24 publication-title: N Engl J Med doi: 10.1056/NEJM199802053380602 – volume: 56 start-page: 777 issue: 6 year: 2012 ident: 233_CR19 publication-title: Acta Anaesthesiol Scand doi: 10.1111/j.1399-6576.2011.02641.x – volume: 15 start-page: 432 issue: 3 year: 2011 ident: 233_CR17 publication-title: Crit Care doi: 10.1186/cc10222 – volume: 345 start-page: 1368 issue: 19 year: 2001 ident: 233_CR3 publication-title: N Engl J Med doi: 10.1056/NEJMoa010307 – volume: 37 start-page: 1672 issue: 10 year: 2011 ident: 233_CR13 publication-title: Intensive Care Med doi: 10.1007/s00134-011-2304-3 – volume: 103 start-page: 238 issue: 2 year: 2009 ident: 233_CR18 publication-title: Br J Anaesth doi: 10.1093/bja/aep123 – volume: 14 start-page: 90 year: 2014 ident: 233_CR20 publication-title: BMC Anesthesiol doi: 10.1186/1471-2253-14-90 – volume: 369 start-page: 428 issue: 5 year: 2013 ident: 233_CR27 publication-title: N Engl J Med doi: 10.1056/NEJMoa1301082 – volume: 26 start-page: 66 issue: 1 year: 2009 ident: 233_CR21 publication-title: Eur J Anaesthesiol doi: 10.1097/EJA.0b013e328319bf5e – volume: 36 start-page: 496 issue: 3 year: 2010 ident: 233_CR9 publication-title: Intensive Care Med doi: 10.1007/s00134-009-1686-y – volume: 88 start-page: 653 issue: 5 year: 1985 ident: 233_CR16 publication-title: Chest doi: 10.1378/chest.88.5.653 – volume: 37 start-page: 2642 issue: 9 year: 2009 ident: 233_CR6 publication-title: Crit Care Med doi: 10.1097/CCM.0b013e3181a590da – volume: 51 start-page: 1268 issue: 9 year: 2007 ident: 233_CR5 publication-title: Acta Anaesthesiol Scand doi: 10.1111/j.1399-6576.2007.01432.x – volume-title: Miller's anesthesia year: 2010 ident: 233_CR15 – volume: 105 start-page: 689 issue: 4 year: 2006 ident: 233_CR10 publication-title: Anesthesiology doi: 10.1097/00000542-200610000-00013 – volume: 269 start-page: 991 year: 1963 ident: 233_CR22 publication-title: N Engl J Med doi: 10.1056/NEJM196311072691901 – reference: 19933173 - Br J Anaesth. 2010 Jan;104(1):16-22 – reference: 9605819 - Lancet. 1998 May 16;351(9114):1501-5 – reference: 19454548 - Br J Anaesth. 2009 Aug;103(2):238-43 – reference: 14059732 - N Engl J Med. 1963 Nov 7;269:991-6 – reference: 23902482 - N Engl J Med. 2013 Aug 1;369(5):428-37 – reference: 19841457 - Ann Intern Med. 2009 Oct 20;151(8):566-76 – reference: 11794169 - N Engl J Med. 2001 Nov 8;345(19):1368-77 – reference: 17714573 - Acta Anaesthesiol Scand. 2007 Oct;51(9):1268-72 – reference: 23161359 - Br J Anaesth. 2013 Mar;110(3):402-8 – reference: 8875011 - Clin Chest Med. 1996 Sep;17(3):555-75 – reference: 19122555 - Eur J Anaesthesiol. 2009 Jan;26(1):66-72 – reference: 26120769 - Anesthesiology. 2015 Sep;123(3):692-713 – reference: 19602972 - Crit Care Med. 2009 Sep;37(9):2642-7 – reference: 17006066 - Anesthesiology. 2006 Oct;105(4):689-95 – reference: 15343024 - Crit Care Med. 2004 Sep;32(9):1928-48 – reference: 19847400 - Intensive Care Med. 2010 Mar;36(3):496-503 – reference: 9449727 - N Engl J Med. 1998 Feb 5;338(6):347-54 – reference: 12917991 - Cochrane Database Syst Rev. 2003;(3):CD003844 – reference: 21739340 - Intensive Care Med. 2011 Oct;37(10):1672-9 – reference: 19347330 - Intensive Care Med. 2009 Jun;35(6):1004-10 – reference: 15754196 - Intensive Care Med. 2005 Apr;31(4):517-23 – reference: 1636714 - Am J Physiol. 1992 Jul;263(1 Pt 1):G38-43 – reference: 25337036 - BMC Anesthesiol. 2014 Oct 14;14:90 – reference: 21672281 - Crit Care. 2011;15(3):432; author reply 432 – reference: 22288953 - Acta Anaesthesiol Scand. 2012 Jul;56(6):777-86 – reference: 3902386 - Chest. 1985 Nov;88(5):653-8 – reference: 24275571 - Curr Opin Crit Care. 2014 Feb;20(1):25-32 |
| SSID | ssj0017803 |
| Score | 2.116935 |
| Snippet | Background
The settings of mechanical ventilation, like tidal volume (VT), occasionally need to be adjusted in the process of anesthesia for some special... The settings of mechanical ventilation, like tidal volume (VT), occasionally need to be adjusted in the process of anesthesia for some special reasons. The aim... Background The settings of mechanical ventilation, like tidal volume (VT), occasionally need to be adjusted in the process of anesthesia for some special... |
| SourceID | pubmedcentral proquest gale pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 75 |
| SubjectTerms | Adolescent Adult Anesthesia Anesthesia, General Anesthesiology Blood Pressure - physiology Critical Care Medicine Emergency Medicine Female Healthy Volunteers Humans Intensive Internal Medicine Male Medicine Medicine & Public Health Middle Aged Perioperative medicine and outcome Prospective Studies Pulse Research Article Respiration, Artificial Statistics as Topic Therapeutics, Experimental Tidal Volume - physiology Young Adult |
| SummonAdditionalLinks | – databaseName: ProQuest Central dbid: BENPR link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Li9RAEC501oMXH_jKukoLgqCETdLTSeckq-ziaRhEYW-hX2EDmlknmV3GX29VuiduBtyLl1z6QSfVVfVVd-UrgLdWi1xKIzAs4RigOHxI4WysM6dqaUpRC19solgs5Pl5uQwHbl1Iq9zZxMFQ25WhM_JjjERSot8X84-Xv2KqGkW3q6GExl04IKay-QwOPp0ull_He4RCJjzcZaYyP-5SChAwfKbEW87j7cQb7dvkG05pP2Fy79Z0cEZnD__3NR7BgwBD2YnfN4_hjmufwM_lBh0lG1JjN2vHrjCOHgTHuovVdccU8w6QETRVa2aosofPpWN0nsv6xuKk3uCxpmUK7SgCzL757Szzf1xuWWBy7Z7C97PTb5-_xKEcQ2wEL_rYlUJKq3XuUoW4IbGiTnhtnUg5RrqIzJR1tjDEezzXvK6FrBNTzHNu8Xu7xPJnMGtXrXsBjMvCysQgOBUIL0qtlNY61VZl1igcFEGyE0tlAlc5lcz4UQ0xi8wrL8mK8tNIktU2gvfjkEtP1HFb53ck64qUGOc1KvyLgKsjOqzqhFjkMvQDPIKjSU9UPjNt3om5CsrfVX9lHMGbsZlGUkJb61Yb6oO2lCN8wyme-801LjsrckRxUkZQTLbd2IEowactbXMxUIMLT48UwYfdBr2xrH99jcPbX-Il3M8GjSnjRB7BrF9v3Cu4Z676plu_Dhr3BxIMNvw priority: 102 providerName: ProQuest |
| Title | Pulse pressure variation shows a direct linear correlation with tidal volume in anesthetized healthy patients |
| URI | https://link.springer.com/article/10.1186/s12871-016-0233-y https://www.ncbi.nlm.nih.gov/pubmed/27609188 https://www.proquest.com/docview/1841805254 https://www.proquest.com/docview/1818337433 https://pubmed.ncbi.nlm.nih.gov/PMC5017055 |
| Volume | 16 |
| WOSCitedRecordID | wos000383130700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVADU databaseName: BioMed Central customDbUrl: eissn: 1471-2253 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017803 issn: 1471-2253 databaseCode: RBZ dateStart: 20010101 isFulltext: true titleUrlDefault: https://www.biomedcentral.com/search/ providerName: BioMedCentral – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals - NZ customDbUrl: eissn: 1471-2253 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017803 issn: 1471-2253 databaseCode: DOA dateStart: 20010101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1471-2253 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017803 issn: 1471-2253 databaseCode: M~E dateStart: 20010101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1471-2253 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017803 issn: 1471-2253 databaseCode: 7X7 dateStart: 20090101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1471-2253 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017803 issn: 1471-2253 databaseCode: BENPR dateStart: 20090101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1471-2253 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017803 issn: 1471-2253 databaseCode: PIMPY dateStart: 20090101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVAVX databaseName: Springer LINK customDbUrl: eissn: 1471-2253 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017803 issn: 1471-2253 databaseCode: RSV dateStart: 20011201 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3ri9QwEB-8OxG_-H5UzyWCICjl2mbTpB9PuUM_3FLOB-unkle5gnZl2z1Z_3on6YProoJ-KZRMQprM4zedyQTghVEsFUIzdEsoOigWH4JZE6rEylLojJWsu2yCLxZiuczy_hx3M2S7DyFJr6m9WIv0qIkduEfX1yXNUhpu9-AArZ1w0nj-4fMYOuAion348rfdJgZoVw1fsUO7OZI7gVJvf05v_9fM78CtHm6S444_7sI1W9-DG2d9QP0-fMs3aBuJz4bdrC25RNfZ7xVpLlY_GiJJZ_OIQ6NyTbS7zKNLnyPuFy5pK4PjdzqOVDWRqDoRU7bVT2tId8hyS_rirc0D-HR68vHtu7C_gSHUjPI2tBkTwiiV2lgiVIgMKyNaGstiis4tgjFprOHalTqeK1qWTJSR5vOUGvxYGxn6EPbrVW0fA6GCGxFpxKMMEUWmpFRKxcrIxGiJnQKIhm0pdF-e3N2S8bXwbopIi24ZC5eS5pax2AbwauzyvavN8Tfil26vCye3OK6W_fEDnJ2rgFUcu8JxCap-GsDhhBLlTU-bB24penlvCvSTY3c5BJsH8Hxsdj1dDlttVxtHg-qTImLDIR51zDVOO-EpAjchAuATthsJXBXwaUtdXfhq4KyriBTA64H5rkzrT6vx5J-on8LNxHNvFkbiEPbb9cY-g-v6sq2a9Qz2-JL7p5jBwZuTRX4-87828C1_f5Z_mXkB_QVqHDU_ |
| linkProvider | Springer Nature |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VggQXHuIVKGAkEBIoahKvE-eAUAVUrVpWPRRpb8GxHTUSZEuSbbX8KH4jM3ESuivRWw9c9uKHnOznmW_i8TcAr0wuYim1wLCEY4Bi8UcKa_w8sqqQOhWFcMUmkulUzmbp0Qb8Hu7CUFrlYBM7Q23mmr6Rb2MkEpL8vph8OP3pU9UoOl0dSmg4WBzY5TmGbM37_U_4_76Oot3Pxx_3_L6qgK8FT1rfpkJKk-exDRW6v8CIIuCFsSLkGLAhwVDGmkSTfO8k50UhZBHoZBJzg-zIBobjvNfgOtrxhFLIktkY4IWJDHh_chrKeLsJKRzBYJ3SfDn3lyu-b90DXHCB6-mZa2e0nevbvfO_vbS7cLsn2WzH7Yp7sGGr-_DjaIE0gHWJv4vasjNVO1iy5mR-3jDFnHtnRLxVzTTVLXGZgoy-VrO2NDipM-esrJhCL4H0uS1_WcPcfdIl63Vqmwfw9Uqe8CFsVvPKPgbGZWJkoJF6CyRPaa5UnudhblRktMJBHgQDDDLdK7FTQZDvWReRyThzyMko-46Qky09eDsOOXUyJJd1fkPYyshE4bxa9TctcHUk9pXtkEZehF6Oe7C10hNNi15tHmCV9aatyf5iyoOXYzONpHS9ys4X1Ac9BUdyilM8cmAelx0lMXJUKT1IVmA-diDB89WWqjzphM-FE3_y4N2wIS4s619v48nlD_ECbu4dfznMDvenB0_hVtTt1tQP5BZstvXCPoMb-qwtm_p5t9cZfLvqffIH4nOSHg |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Li9RAEC50lcWL79Xoqi0IghI2SU8nneOiDoo6DPhgb6FfYQOaWSaZlfHXW5VOwmZQQbzMpR90uqurvpqq_grgmdUildIIdEs4OigOf6RwNtSJU6U0uSiFLzaRLRby5CRf9nVOmyHbfQhJ-jcNxNJUt0dntvRXXKZHTUxAH91gSqDlPNxehiszqhlE7vqnr2MYIZMR70OZvx02MUa7KvmCTdrNl9wJmna2aH7jv7_iJlzvYSg79nJzCy65-jbsf-wD7Xfg-3KDNpN1WbKbtWPn6FJ3Z8ia09WPhinmbSEjlKrWzFCRD59Wx-ivXdZWFuf3uo9VNVOoUhFrttVPZ5l_fLllPalrcxe-zN98fvU27CszhEbwrA1dLqS0WqcuVgghIivKiJfWiZij04sgTVlnM0MUyDPNy1LIMjLZLOUWP9ZFlh_AXr2q3X1gXGZWRgZxqkCkkWultNaxtiqxRuGgAKLhiArT05ZT9YxvRee-yLTw21hQqhptY7EN4MU45Mxzdvyt83M694LuM85rVP8sAVdHzFjFMRHKJWgSeACHk554D820eZCcotcDTYH-c0xFI8QsgKdjM42k3LbarTbUB9UqRySHU9zzgjYuO8lSBHRSBpBNRHDsQOzg05a6Ou1YwoVnSgrg5SCIF5b1p9148E-9n8D-8vW8-PBu8f4hXEs6Qc7DSB7CXrveuEdw1Zy3VbN-3N3KX1yoOvc |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pulse+pressure+variation+shows+a+direct+linear+correlation+with+tidal+volume+in+anesthetized+healthy+patients&rft.jtitle=BMC+anesthesiology&rft.au=Liu%2C+Yi&rft.au=Lou%2C+Jing-sheng&rft.au=Mi%2C+Wei-dong&rft.au=Yuan%2C+Wei-xiu&rft.date=2016-09-08&rft.pub=BioMed+Central&rft.eissn=1471-2253&rft.volume=16&rft.issue=1&rft_id=info:doi/10.1186%2Fs12871-016-0233-y&rft.externalDocID=10_1186_s12871_016_0233_y |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1471-2253&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1471-2253&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1471-2253&client=summon |