Long Noncoding RNAs as Novel Biomarkers Have a Promising Future in Cancer Diagnostics

Cancers have a high mortality rate due to lack of suitable specific early diagnosis tumor biomarkers. Emerging evidence is accumulating that lncRNAs (long noncoding RNAs) are involved in tumorigenesis, tumor cells proliferation, invasion, migration, apoptosis, and angiogenesis. Furthermore, extracel...

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Veröffentlicht in:Disease markers Jg. 2016; H. 2016; S. 1 - 10
Hauptverfasser: Shi, Ting, Cao, Yingli, Gao, Ge
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Cairo, Egypt Hindawi Publishing Corporation 01.01.2016
John Wiley & Sons, Inc
Schlagworte:
Biological markers
Biomarkers, Tumor - blood
Biomarkers, Tumor - genetics
Biomarkers, Tumor - urine
Cancer
Diagnosis
Early Detection of Cancer
Gastric Juice - chemistry
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Health aspects
Humans
Molecular Diagnostic Techniques - standards
Neoplasms - diagnosis
Neoplasms - genetics
Practice Guidelines as Topic
Review
RNA
RNA, Long Noncoding - blood
RNA, Long Noncoding - genetics
RNA, Long Noncoding - urine
Saliva - chemistry
ISSN:0278-0240, 1875-8630, 1875-8630
Online-Zugang:Volltext
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Abstract Cancers have a high mortality rate due to lack of suitable specific early diagnosis tumor biomarkers. Emerging evidence is accumulating that lncRNAs (long noncoding RNAs) are involved in tumorigenesis, tumor cells proliferation, invasion, migration, apoptosis, and angiogenesis. Furthermore, extracellular lncRNAs can circulate in body fluids; they can be detected and strongly resist RNases. Many researchers have found that lncRNAs could be good candidates for tumor biomarkers and possessed high specificity, high sensitivity, and noninvasive characteristics. In this review, we summarize the detection methods and possible sources of circulating lncRNAs and outline the biological functions and expression level of the most significant lncRNAs in tissues, cell lines, and body fluids (whole blood, plasma, urine, gastric juice, and saliva) of different kinds of tumors. We evaluate the diagnostic performance of lncRNAs as tumor biomarkers. However, the biological functions and the mechanisms of circulating lncRNAs secretion have not been fully understood. The uniform normalization protocol of sample collection, lncRNAs extraction, endogenous control selection, quality assessment, and quantitative data analysis has not been established. Therefore, we put forward some recommendations that might be investigated in the future if we want to adopt lncRNAs in clinical practice.
AbstractList Cancers have a high mortality rate due to lack of suitable specific early diagnosis tumor biomarkers. Emerging evidence is accumulating that lncRNAs (long noncoding RNAs) are involved in tumorigenesis, tumor cells proliferation, invasion, migration, apoptosis, and angiogenesis. Furthermore, extracellular lncRNAs can circulate in body fluids; they can be detected and strongly resist RNases. Many researchers have found that lncRNAs could be good candidates for tumor biomarkers and possessed high specificity, high sensitivity, and noninvasive characteristics. In this review, we summarize the detection methods and possible sources of circulating lncRNAs and outline the biological functions and expression level of the most significant lncRNAs in tissues, cell lines, and body fluids (whole blood, plasma, urine, gastric juice, and saliva) of different kinds of tumors. We evaluate the diagnostic performance of lncRNAs as tumor biomarkers. However, the biological functions and the mechanisms of circulating lncRNAs secretion have not been fully understood. The uniform normalization protocol of sample collection, lncRNAs extraction, endogenous control selection, quality assessment, and quantitative data analysis has not been established. Therefore, we put forward some recommendations that might be investigated in the future if we want to adopt lncRNAs in clinical practice.
Cancers have a high mortality rate due to lack of suitable specific early diagnosis tumor biomarkers. Emerging evidence is accumulating that lncRNAs (long noncoding RNAs) are involved in tumorigenesis, tumor cells proliferation, invasion, migration, apoptosis, and angiogenesis. Furthermore, extracellular lncRNAs can circulate in body fluids; they can be detected and strongly resist RNases. Many researchers have found that lncRNAs could be good candidates for tumor biomarkers and possessed high specificity, high sensitivity, and noninvasive characteristics. In this review, we summarize the detection methods and possible sources of circulating lncRNAs and outline the biological functions and expression level of the most significant lncRNAs in tissues, cell lines, and body fluids (whole blood, plasma, urine, gastric juice, and saliva) of different kinds of tumors. We evaluate the diagnostic performance of lncRNAs as tumor biomarkers. However, the biological functions and the mechanisms of circulating lncRNAs secretion have not been fully understood. The uniform normalization protocol of sample collection, lncRNAs extraction, endogenous control selection, quality assessment, and quantitative data analysis has not been established. Therefore, we put forward some recommendations that might be investigated in the future if we want to adopt lncRNAs in clinical practice.Cancers have a high mortality rate due to lack of suitable specific early diagnosis tumor biomarkers. Emerging evidence is accumulating that lncRNAs (long noncoding RNAs) are involved in tumorigenesis, tumor cells proliferation, invasion, migration, apoptosis, and angiogenesis. Furthermore, extracellular lncRNAs can circulate in body fluids; they can be detected and strongly resist RNases. Many researchers have found that lncRNAs could be good candidates for tumor biomarkers and possessed high specificity, high sensitivity, and noninvasive characteristics. In this review, we summarize the detection methods and possible sources of circulating lncRNAs and outline the biological functions and expression level of the most significant lncRNAs in tissues, cell lines, and body fluids (whole blood, plasma, urine, gastric juice, and saliva) of different kinds of tumors. We evaluate the diagnostic performance of lncRNAs as tumor biomarkers. However, the biological functions and the mechanisms of circulating lncRNAs secretion have not been fully understood. The uniform normalization protocol of sample collection, lncRNAs extraction, endogenous control selection, quality assessment, and quantitative data analysis has not been established. Therefore, we put forward some recommendations that might be investigated in the future if we want to adopt lncRNAs in clinical practice.
Audience Academic
Author Gao, Ge
Shi, Ting
Cao, Yingli
AuthorAffiliation Faculty of Laboratory Medicine, Xiangya Medical College, Central South University, Changsha, Hunan 41001, China
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Snippet Cancers have a high mortality rate due to lack of suitable specific early diagnosis tumor biomarkers. Emerging evidence is accumulating that lncRNAs (long...
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SubjectTerms Biological markers
Biomarkers, Tumor - blood
Biomarkers, Tumor - genetics
Biomarkers, Tumor - urine
Cancer
Diagnosis
Early Detection of Cancer
Gastric Juice - chemistry
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Health aspects
Humans
Molecular Diagnostic Techniques - standards
Neoplasms - diagnosis
Neoplasms - genetics
Practice Guidelines as Topic
Review
RNA
RNA, Long Noncoding - blood
RNA, Long Noncoding - genetics
RNA, Long Noncoding - urine
Saliva - chemistry
Title Long Noncoding RNAs as Novel Biomarkers Have a Promising Future in Cancer Diagnostics
URI https://search.emarefa.net/detail/BIM-1103800
https://dx.doi.org/10.1155/2016/9085195
https://www.ncbi.nlm.nih.gov/pubmed/27143813
https://www.proquest.com/docview/1787088500
https://pubmed.ncbi.nlm.nih.gov/PMC4842029
Volume 2016
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