Telomeric repeat-containing RNA is dysregulated in acute myeloid leukemia

•TERRA is repressed in primary human hematopoietic cells (in the bone marrow and peripheral blood), regardless of their telomere lengths.•TERRA is dysregulated in a subset of AML characterized by higher R-loop formation and low TERT and RNAseH2 expression. [Display omitted] TERRA (telomeric repeat-c...

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Bibliographic Details

Published in:	Blood advances Vol. 7; no. 22; pp. 7067 - 7078
Main Authors:	Catto, Luiz Fernando B., Zanelatto, Leonardo C., Donaires, Flavia S., de Carvalho, Vinicius S., Santana, Bárbara A., Pinto, André L., Fantacini, Daianne, de Souza, Lucas Eduardo B., Fonseca, Natasha P., Telho, Bruno S., Ayrosa Madeira, Maria Isabel, Barbosa Pagnano, Katia Borgia, Firmato, Ana Beatriz, Fagundes, Evandro Maranhão, Higashi, Marcia, Nunes, Elenaide Coutinho, Traina, Fabiola, Lobo de F. Pontes, Lorena, Rego, Eduardo M., Calado, Rodrigo T.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 28.11.2023 The American Society of Hematology
Subjects:	Cell Line DNA Humans Leukemia, Myeloid, Acute - genetics Myeloid Neoplasia Precursor Cell Lymphoblastic Leukemia-Lymphoma RNA, Long Noncoding Telomerase
ISSN:	2473-9529, 2473-9537, 2473-9537
Online Access:	Get full text
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