Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness

Glioblastoma (GBM) is the most aggressive tumor of the brain. NF1 , a tumor suppressor gene and RAS-GTPase, is one of the highly mutated genes in GBM. Dysregulated NF1 expression promotes cell invasion, proliferation, and tumorigenesis. Loss of NF1 expression in glioblastoma is associated with incre...

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Bibliographic Details
Published in:	Oncogene Vol. 38; no. 27; pp. 5367 - 5380
Main Authors:	Fadhlullah, Siti Farah Bte, Halim, Nurashikin Bte Abdul, Yeo, Jacqueline Y. T., Ho, Rachel L. Y., Um, Phoebe, Ang, Beng Ti, Tang, Carol, Ng, Wai H., Virshup, David M., Ho, Ivy A. W.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.07.2019 Nature Publishing Group
Subjects:	13 13/1 13/100 13/106 13/109 13/44 13/51 13/95 14/19 14/63 38 38/22 38/70 38/89 38/90 42 45/23 45/29 631/532/71 631/67/1922 631/67/322 631/80/84/2341 64/60 82/80 Animals Apoptosis Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain tumors Care and treatment Cell Biology Cell Line, Tumor Cell proliferation Gene expression Gene mutations Genetic aspects Glioblastoma Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma cells Glioblastoma multiforme Glioma Glioma cells Guanosine diphosphate Guanosine triphosphatases Guanosine triphosphate Human Genetics Humans Internal Medicine Invasiveness Leucine Leucine - metabolism Medicine Medicine & Public Health Mesenchyme Mice Mice, Inbred NOD Mice, SCID Mutation Neoplasm Invasiveness - genetics Neurofibromin 1 Neurofibromin 1 - genetics Neurofibromin 1 - metabolism Oncology Tumor suppressor genes Tumorigenesis
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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