Vitamin D levels and perinatal depressive symptoms in women at risk: a secondary analysis of the mothers, omega-3, and mental health study

Background Vitamin D insufficiency may be associated with depressive symptoms in non-pregnant adults. We performed this study to evaluate whether low maternal vitamin D levels are associated with depressive symptoms in pregnancy. Methods This study was a secondary analysis of a randomized trial desi...

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Vydané v:BMC pregnancy and childbirth Ročník 16; číslo 1; s. 203
Hlavní autori: Williams, Jennifer Anne, Romero, Vivian C., Clinton, Chelsea M., Vazquez, Delia M., Marcus, Sheila M., Chilimigras, Julie L., Hamilton, Susan E., Allbaugh, Lucy J., Vahratian, Anjel M., Schrader, Ronald M., Mozurkewich, Ellen L.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London BioMed Central 03.08.2016
Springer Nature B.V
Predmet:
Adult
Anxiety
Depression - blood
Depression - prevention & control
Depression, Postpartum - blood
Depression, Postpartum - prevention & control
Dietary Supplements
Double-Blind Method
Fatty Acids, Omega-3 - administration & dosage
Female
Gynecology
Humans
Maternal and Child Health
Maternal health and pregnancy
Maternal Serum Screening Tests - methods
Medicine
Medicine & Public Health
Mental depression
Mental health
Omega-3 fatty acids
Postpartum Period - blood
Pregnancy
Pregnancy Complications - blood
Pregnancy Complications - prevention & control
Pregnancy Complications - psychology
Pregnancy Trimesters - blood
Psychiatric Status Rating Scales
Regression Analysis
Reproductive Medicine
Research Article
Risk Factors
Systematic review
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Womens health
United States > US
Michigan
Pregnancy
Vitamin D
Depression
ISSN:1471-2393, 1471-2393
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Shrnutí:Background Vitamin D insufficiency may be associated with depressive symptoms in non-pregnant adults. We performed this study to evaluate whether low maternal vitamin D levels are associated with depressive symptoms in pregnancy. Methods This study was a secondary analysis of a randomized trial designed to assess whether prenatal omega-3 fatty acid supplementation would prevent depressive symptoms. Pregnant women from Michigan who were at risk for depression based on Edinburgh Postnatal Depression Scale Score or history of depression were enrolled. Participants completed the Beck Depression Inventory (BDI) and Mini International Neuropsychiatric Interview at 12–20 weeks, 26–28 weeks, 34–36 weeks, and 6–8 weeks postpartum. Vitamin D levels were measured at 12–20 weeks ( N  = 117) and 34–36 weeks ( N  = 112). Complete datasets were available on 105 subjects. Using regression analyses, we evaluated the relationship between vitamin D levels with BDI scores as well as with MINI diagnoses of major depressive disorder and generalized anxiety disorder. Our primary outcome measure was the association of maternal vitamin D levels with BDI scores during early and late pregnancy and postpartum. Results We found that vitamin D levels at 12–20 weeks were inversely associated with BDI scores both at 12—20 and at 34–36 weeks’ gestation ( P  < 0.05, both). For every one unit increase in vitamin D in early pregnancy, the average decrease in the mean BDI score was .14 units. Vitamin D levels were not associated with diagnoses of major depressive disorder or generalized anxiety disorder. Conclusions In women at risk for depression, early pregnancy low vitamin D levels are associated with higher depressive symptom scores in early and late pregnancy. Future investigations should study whether vitamin D supplementation in early pregnancy may prevent perinatal depressive symptoms. Trial registration https://clinicaltrials.gov/ Registration Number: NCT00711971
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ISSN:1471-2393
1471-2393
DOI:10.1186/s12884-016-0988-7