Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor overexpressed gene (TOG) domain arrays

XMAP215/Stu2/Alp14 proteins accelerate microtubule plus-end polymerization by recruiting tubulins via arrays of tumor overexpressed gene (TOG) domains, yet their mechanism remains unknown. Here, we describe the biochemical and structural basis for TOG arrays in recruiting and polymerizing tubulins....

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Veröffentlicht in:	eLife Jg. 7
Hauptverfasser:	Nithianantham, Stanley, Cook, Brian D, Beans, Madeleine, Guo, Fei, Chang, Fred, Al-Bassam, Jawdat
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England eLife Science Publications, Ltd 13.11.2018 eLife Sciences Publications Ltd eLife Sciences Publications, Ltd
Schlagworte:	Alp14 Animation Biochemistry Cell adhesion & migration Cell Biology Crystallography, X-Ray Electron microscopy Fungal Proteins - chemistry Fungal Proteins - metabolism Fungi - metabolism Interfaces Mass spectrometry Microscopy Microscopy, Electron microtubule Microtubule-Associated Proteins - chemistry Microtubule-Associated Proteins - metabolism Microtubules - chemistry Microtubules - metabolism Models, Molecular Money Peptides Polymer crosslinking Polymerization Protein Binding Protein Conformation Protein Multimerization Proteins Scientific imaging Structural Biology and Molecular Biophysics TOG domain Tubulin Tubulin - chemistry Tubulin - metabolism Tumors x-ray XMAP215 United States > US California XMAP215 microtubule cell biology x-ray S. pombe tubulin structural biology molecular biophysics Alp14 TOG domain
ISSN:	2050-084X, 2050-084X
Online-Zugang:	Volltext
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