Toward a Continuous Intravascular Glucose Monitoring System
Proof-of-concept studies that display the potential of using a glucose-sensitive hydrogel as a continuous glucose sensor are presented. The swelling ratio, porosity, and diffusivity of the hydrogel increased with glucose concentration. In glucose solutions of 50, 100, 200, and 300 mg/dL, the hydroge...
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| Veröffentlicht in: | Sensors (Basel, Switzerland) Jg. 11; H. 1; S. 409 - 424 |
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01.01.2011
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| Abstract | Proof-of-concept studies that display the potential of using a glucose-sensitive hydrogel as a continuous glucose sensor are presented. The swelling ratio, porosity, and diffusivity of the hydrogel increased with glucose concentration. In glucose solutions of 50, 100, 200, and 300 mg/dL, the hydrogel swelling ratios were 4.9, 12.3, 15.9, and 21.7, respectively, and the swelling was reversible. The impedance across the hydrogel depended solely on the thickness and had an average increase of 47 W/mm. The hydrogels exposed to a hyperglycemic solution were more porous than the hydrogels exposed to a normal glycemic solution. The diffusivity of 390 Da MW fluorescein isothiocyanate in hydrogels exposed to normal and hyperglycemic solutions was examined using fluorescence recovery after photobleaching and was found to be 9.3 × 10−14 and 41.4 × 10−14 m2/s, respectively, compared to 6.2 × 10−10 m2/s in glucose solution. There was no significant difference between the permeability of hydrogels in normal and hyperglycemic glucose solutions with averages being 5.26 × 10−17 m2 and 5.80 × 10−17 m2, respectively, which resembles 2–4% agarose gels. A prototype design is presented for continuous intravascular glucose monitoring by attaching a glucose sensor to an FDA-approved stent. |
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| AbstractList | Proof-of-concept studies that display the potential of using a glucose-sensitive hydrogel as a continuous glucose sensor are presented. The swelling ratio, porosity, and diffusivity of the hydrogel increased with glucose concentration. In glucose solutions of 50, 100, 200, and 300 mg/dL, the hydrogel swelling ratios were 4.9, 12.3, 15.9, and 21.7, respectively, and the swelling was reversible. The impedance across the hydrogel depended solely on the thickness and had an average increase of 47 Ω/mm. The hydrogels exposed to a hyperglycemic solution were more porous than the hydrogels exposed to a normal glycemic solution. The diffusivity of 390 Da MW fluorescein isothiocyanate in hydrogels exposed to normal and hyperglycemic solutions was examined using fluorescence recovery after photobleaching and was found to be 9.3 × 10−14 and 41.4 × 10−14 m2/s, respectively, compared to 6.2 × 10−10 m2/s in glucose solution. There was no significant difference between the permeability of hydrogels in normal and hyperglycemic glucose solutions with averages being 5.26 × 10−17 m2 and 5.80 × 10−17 m2, respectively, which resembles 2–4% agarose gels. A prototype design is presented for continuous intravascular glucose monitoring by attaching a glucose sensor to an FDA-approved stent. Proof-of-concept studies that display the potential of using a glucose-sensitive hydrogel as a continuous glucose sensor are presented. The swelling ratio, porosity, and diffusivity of the hydrogel increased with glucose concentration. In glucose solutions of 50, 100, 200, and 300 mg/dL, the hydrogel swelling ratios were 4.9, 12.3, 15.9, and 21.7, respectively, and the swelling was reversible. The impedance across the hydrogel depended solely on the thickness and had an average increase of 47 W/mm. The hydrogels exposed to a hyperglycemic solution were more porous than the hydrogels exposed to a normal glycemic solution. The diffusivity of 390 Da MW fluorescein isothiocyanate in hydrogels exposed to normal and hyperglycemic solutions was examined using fluorescence recovery after photobleaching and was found to be 9.3 × 10−14 and 41.4 × 10−14 m2/s, respectively, compared to 6.2 × 10−10 m2/s in glucose solution. There was no significant difference between the permeability of hydrogels in normal and hyperglycemic glucose solutions with averages being 5.26 × 10−17 m2 and 5.80 × 10−17 m2, respectively, which resembles 2–4% agarose gels. A prototype design is presented for continuous intravascular glucose monitoring by attaching a glucose sensor to an FDA-approved stent. Proof-of-concept studies that display the potential of using a glucose-sensitive hydrogel as a continuous glucose sensor are presented. The swelling ratio, porosity, and diffusivity of the hydrogel increased with glucose concentration. In glucose solutions of 50, 100, 200, and 300 mg/dL, the hydrogel swelling ratios were 4.9, 12.3, 15.9, and 21.7, respectively, and the swelling was reversible. The impedance across the hydrogel depended solely on the thickness and had an average increase of 47 Ω/mm. The hydrogels exposed to a hyperglycemic solution were more porous than the hydrogels exposed to a normal glycemic solution. The diffusivity of 390 Da MW fluorescein isothiocyanate in hydrogels exposed to normal and hyperglycemic solutions was examined using fluorescence recovery after photobleaching and was found to be 9.3 × 10(-14) and 41.4 × 10(-14) m(2)/s, respectively, compared to 6.2 × 10(-10) m(2)/s in glucose solution. There was no significant difference between the permeability of hydrogels in normal and hyperglycemic glucose solutions with averages being 5.26 × 10(-17) m(2) and 5.80 × 10(-17) m(2), respectively, which resembles 2-4% agarose gels. A prototype design is presented for continuous intravascular glucose monitoring by attaching a glucose sensor to an FDA-approved stent.Proof-of-concept studies that display the potential of using a glucose-sensitive hydrogel as a continuous glucose sensor are presented. The swelling ratio, porosity, and diffusivity of the hydrogel increased with glucose concentration. In glucose solutions of 50, 100, 200, and 300 mg/dL, the hydrogel swelling ratios were 4.9, 12.3, 15.9, and 21.7, respectively, and the swelling was reversible. The impedance across the hydrogel depended solely on the thickness and had an average increase of 47 Ω/mm. The hydrogels exposed to a hyperglycemic solution were more porous than the hydrogels exposed to a normal glycemic solution. The diffusivity of 390 Da MW fluorescein isothiocyanate in hydrogels exposed to normal and hyperglycemic solutions was examined using fluorescence recovery after photobleaching and was found to be 9.3 × 10(-14) and 41.4 × 10(-14) m(2)/s, respectively, compared to 6.2 × 10(-10) m(2)/s in glucose solution. There was no significant difference between the permeability of hydrogels in normal and hyperglycemic glucose solutions with averages being 5.26 × 10(-17) m(2) and 5.80 × 10(-17) m(2), respectively, which resembles 2-4% agarose gels. A prototype design is presented for continuous intravascular glucose monitoring by attaching a glucose sensor to an FDA-approved stent. Proof-of-concept studies that display the potential of using a glucose-sensitive hydrogel as a continuous glucose sensor are presented. The swelling ratio, porosity, and diffusivity of the hydrogel increased with glucose concentration. In glucose solutions of 50, 100, 200, and 300 mg/dL, the hydrogel swelling ratios were 4.9, 12.3, 15.9, and 21.7, respectively, and the swelling was reversible. The impedance across the hydrogel depended solely on the thickness and had an average increase of 47 W/mm. The hydrogels exposed to a hyperglycemic solution were more porous than the hydrogels exposed to a normal glycemic solution. The diffusivity of 390 Da MW fluorescein isothiocyanate in hydrogels exposed to normal and hyperglycemic solutions was examined using fluorescence recovery after photobleaching and was found to be 9.3 × 10-14 and 41.4 × 10-14 m2/s, respectively, compared to 6.2 × 10-10 m2/s in glucose solution. There was no significant difference between the permeability of hydrogels in normal and hyperglycemic glucose solutions with averages being 5.26 × 10-17 m2 and 5.80 × 10-17 m2, respectively, which resembles 2-4% agarose gels. A prototype design is presented for continuous intravascular glucose monitoring by attaching a glucose sensor to an FDA-approved stent. Proof-of-concept studies that display the potential of using a glucose-sensitive hydrogel as a continuous glucose sensor are presented. The swelling ratio, porosity, and diffusivity of the hydrogel increased with glucose concentration. In glucose solutions of 50, 100, 200, and 300 mg/dL, the hydrogel swelling ratios were 4.9, 12.3, 15.9, and 21.7, respectively, and the swelling was reversible. The impedance across the hydrogel depended solely on the thickness and had an average increase of 47 Ω/mm. The hydrogels exposed to a hyperglycemic solution were more porous than the hydrogels exposed to a normal glycemic solution. The diffusivity of 390 Da MW fluorescein isothiocyanate in hydrogels exposed to normal and hyperglycemic solutions was examined using fluorescence recovery after photobleaching and was found to be 9.3 × 10(-14) and 41.4 × 10(-14) m(2)/s, respectively, compared to 6.2 × 10(-10) m(2)/s in glucose solution. There was no significant difference between the permeability of hydrogels in normal and hyperglycemic glucose solutions with averages being 5.26 × 10(-17) m(2) and 5.80 × 10(-17) m(2), respectively, which resembles 2-4% agarose gels. A prototype design is presented for continuous intravascular glucose monitoring by attaching a glucose sensor to an FDA-approved stent. |
| Author | Beier, Brooke Matsumoto, Akira Panitch, Alyssa Irazoqui, Pedro Musick, Katherine Nauman, Eric |
| AuthorAffiliation | 2 Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 Japan; E-Mail: amatsumoto@bmw.t.u-tokyo.ac.jp (A.M.) 1 The Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA; E-Mails: kmmusick@purdue.edu (K.M.); apanitch@purdue.edu (A.P.); enauman@purdue.edu (E.N.); pip@purdue.edu (P.I.) 3 Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907, USA 4 School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA |
| AuthorAffiliation_xml | – name: 3 Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907, USA – name: 2 Department of Bioengineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 Japan; E-Mail: amatsumoto@bmw.t.u-tokyo.ac.jp (A.M.) – name: 1 The Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA; E-Mails: kmmusick@purdue.edu (K.M.); apanitch@purdue.edu (A.P.); enauman@purdue.edu (E.N.); pip@purdue.edu (P.I.) – name: 4 School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22344366$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1186/1475-2840-2-1 10.1016/0002-9149(90)90711-9 10.1183/09031936.02.00014602 10.1021/ma035382i 10.1016/S1367-5931(02)00371-X 10.2337/dc08-9017 10.1016/S0006-3495(76)85755-4 10.1016/S0006-3495(02)75555-0 10.1366/0003702924124493 10.1002/bit.260430310 10.1016/S0169-409X(01)00241-1 10.1002/aic.690420504 10.1111/j.1540-8183.2009.00483.x 10.1109/TMTT.2009.2029954 10.2337/diacare.27.5.1047 10.1114/1.195 10.1109/TBME.2010.2041058 10.1021/ja982975d 10.2337/diacare.23.2.143 10.3390/s8010561 10.1001/jama.276.17.1409 10.1007/s00125-005-1832-1 10.1063/1.437602 |
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| Keywords | intravascular stent, wireless continuous biosensors hydrogels polymers glucose monitoring |
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| SubjectTerms | Acids Biosensing Techniques biosensors continuous Diabetes Diabetic neuropathy Diffusion Glucose - analysis Glucose monitoring Heart failure Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry Hydrogels intravascular Isothiocyanates - chemistry Monitoring systems Permeability Physiology polymers Sensors stent, wireless |
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| Title | Toward a Continuous Intravascular Glucose Monitoring System |
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