Patients with HFpEF and HFrEF have different clinical characteristics but similar prognosis: a retrospective cohort study

Background Globally, heart failure (HF) has been recognized as one of the major cardiovascular disorder with high morbidity, mortality and considerable social impact. In Sub Saharan African countries, HF has turned out as a leading form of cardiovascular diseases, and has considerable socioeconomic...

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Published in:BMC cardiovascular disorders Vol. 16; no. 1; p. 232
Main Authors: Abebe, Tamrat Befekadu, Gebreyohannes, Eyob Alemayehu, Tefera, Yonas Getaye, Abegaz, Tadesse Melaku
Format: Journal Article
Language:English
Published: London BioMed Central 21.11.2016
BioMed Central Ltd
Springer Nature B.V
Subjects:
Analysis
Angiology
Blood Transfusion Medicine
Calcium channels
Cardiac output
Cardiac Surgery
Cardiology
Cardiovascular agents
Care and treatment
Dosage and administration
Echocardiography - methods
Ethiopia - epidemiology
Female
Follow-Up Studies
Health aspects
Heart failure
Heart Failure - diagnosis
Heart Failure - mortality
Heart Failure - physiopathology
Humans
Hypertension
Internal Medicine
Male
Medicine
Medicine & Public Health
Middle Aged
Non-coronary artery cardiac disease
Patient outcomes
Prognosis
Research Article
Retrospective Studies
Stroke Volume - physiology
Survival Rate - trends
Time Factors
Ventricular Function, Left - physiology
Spain
Heart failure
Clinical characteristics
Survival
Ethiopia
Ejection fraction
ISSN:1471-2261, 1471-2261
Online Access:Get full text
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Summary:Background Globally, heart failure (HF) has been recognized as one of the major cardiovascular disorder with high morbidity, mortality and considerable social impact. In Sub Saharan African countries, HF has turned out as a leading form of cardiovascular diseases, and has considerable socioeconomic impact. However, there are differences in clinical characteristics and survival status among patients with preserved (HFpEF) and reduced (HFrEF) ejection fraction. The aim of this study is to outline the clinical characteristics and medication profile, assess the survival status and prognostic factors of Ethiopian HF patients with HFrEF and HFpEF. Methods A retrospective cohort study was carried out and we employed medical records of patient’s, admitted as a result of HF to the University of Gondar Referral Hospital in the period between December 02, 2010 and December 01, 2015 due to HF. Kaplan Meier curve was used to analyze the survival status and log rank test was used to compare the curves. Cox regression was used to analyze independent predictors of mortality in all HF patients. Results Of the 850 patients who were admitted due to HF, 311 patients met the inclusion criteria. Majority of the patients had HFpEF (52.73%) and tend to be women (76.22%). They predominantly had etiologies of valvular and hypertensive heart diseases, and took calcium channel blockers and anticoagulants. Conversely, patients with HFrEF had etiologies of ischemic heart disease and dilated cardiomyopathy and were prescribed angiotensine converting inhibitors (ACEI) and beta blockers. Kaplan Meier curves and Log rank test ( p  = 0.807) showed that there was no statistically significant difference in the mortality difference among patients with HFpEF and HFrEF. On the other hand, Cox regression analysis showed advanced age, lower sodium level, higher creatinine level and absence of medications like ACEI, spironolactone and statins independently predicted mortality in all HF patients. Conclusions Different clinical characteristics were found in both groups of HF patients. There was no difference in survival outcome between patients with HFrEF and HFpEF.
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ISSN:1471-2261
1471-2261
DOI:10.1186/s12872-016-0418-9