Pegcetacoplan controls hemolysis in complement inhibitor–naive patients with paroxysmal nocturnal hemoglobinuria

•Complement inhibitor–naive patients with PNH had greater hemoglobin stabilization and LDH reduction with pegcetacoplan vs control.•Pegcetacoplan’s comprehensive control of hemolysis and favorable safety profile in these patients may help expand the treatment population. [Display omitted] Paroxysmal...

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Veröffentlicht in:	Blood advances Jg. 7; H. 11; S. 2468 - 2478
Hauptverfasser:	Wong, Raymond Siu Ming, Navarro-Cabrera, Juan Ramon, Comia, Narcisa Sonia, Goh, Yeow Tee, Idrobo, Henry, Kongkabpan, Daolada, Gómez-Almaguer, David, Al-Adhami, Mohammed, Ajayi, Temitayo, Alvarenga, Paulo, Savage, Jessica, Deschatelets, Pascal, Francois, Cedric, Grossi, Federico, Dumagay, Teresita
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 13.06.2023 The American Society of Hematology
Schlagworte:	Adult Antibodies, Monoclonal, Humanized - adverse effects Clinical Trials and Observations Complement Inactivating Agents - adverse effects Hemoglobins Hemoglobinuria, Paroxysmal - drug therapy Hemolysis Humans L-Lactate Dehydrogenase
ISSN:	2473-9529, 2473-9537, 2473-9537
Online-Zugang:	Volltext
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