Genome Analysis of Anti-Phage Defense Systems and Defense Islands in Stenotrophomonas maltophilia: Preservation and Variability

Anti-phage defense systems are widespread in bacteria due to the latter continuous adaptation to infection by bacteriophages (phages). Stenotrophomonas maltophilia has a high degree of intrinsic antibiotic resistance, which makes phage therapy relevant for the treatment of infections caused by this...

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Vydáno v:Viruses Ročník 16; číslo 12; s. 1903
Hlavní autoři: Jdeed, Ghadeer, Morozova, Vera V., Tikunova, Nina V.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 01.12.2024
MDPI
Témata:
Analysis
anti-phage defense systems
Antibiotic resistance
Antibiotics
Bacteria
Bacteriophages
Bacteriophages - genetics
Bacteriophages - physiology
Control
CRISPR
Defense
defense islands
Dosage and administration
Drug resistance
Drug resistance in microorganisms
E coli
Genes
Genetic aspects
Genome, Bacterial
Genomes
Genomic analysis
Genomic Islands
Identification and classification
Islands
phage therapy
Phages
Phylogeny
Prevention
S. maltophilia
Stenotrophomonas maltophilia
Stenotrophomonas maltophilia - genetics
Stenotrophomonas maltophilia - virology
Strains (organisms)
Russia
S. maltophilia
defense islands
anti-phage defense systems
phage therapy
ISSN:1999-4915, 1999-4915
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Shrnutí:Anti-phage defense systems are widespread in bacteria due to the latter continuous adaptation to infection by bacteriophages (phages). Stenotrophomonas maltophilia has a high degree of intrinsic antibiotic resistance, which makes phage therapy relevant for the treatment of infections caused by this species. Studying the array of anti-phage defense systems that could be found in S. maltophilia helps in better adapting the phages to the systems present in the pathogenic bacteria. Pangenome analysis of the available S. maltophilia strains with complete genomes that were downloaded from GenBank, including five local genomes, indicated a wide set of 72 defense systems and subsystems that varied between the strains. Seven of these systems were present in more than 20% of the studied genomes and the proteins encoded by the systems were variable in most of the cases. A total of 27 defense islands were revealed where defense systems were found; however, more than 60% of the instances of systems were found in four defense islands. Several elements linked to the transfer of these systems were found. No obvious associations between the pattern of distribution of the anti-phage defense systems of S. maltophilia and the phylogenetic features or the isolation site were found.
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ISSN:1999-4915
1999-4915
DOI:10.3390/v16121903