Modulation of autoimmune rheumatic diseases by oestrogen and progesterone

Key Points Sexual dimorphism in the risk and expression of human autoimmune rheumatic diseases involves the immunomodulatory effects of postpubertal levels of sex steroid hormones Oestrogen increases the risk of SLE in genetically susceptible women by increasing type 1 interferon production and favo...

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Bibliographic Details
Published in:	Nature reviews. Rheumatology Vol. 10; no. 12; pp. 740 - 751
Main Authors:	Hughes, Grant C., Choubey, Divaker
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.12.2014 Nature Publishing Group
Subjects:	692/420/2780 692/699/1670 692/699/1670/1613 692/699/1670/498 Arthritis, Rheumatoid - etiology Autoantibodies - physiology Autoimmune diseases Autoimmune Diseases - etiology B-Lymphocytes - physiology Care and treatment Estrogen Estrogens - physiology Gender differences Hormones Humans Immune system Immunology Interferons - physiology Lupus Lupus Erythematosus, Systemic - etiology Medicine Medicine & Public Health Pregnancy complications Progesterone Progesterone - physiology Properties review-article Rheumatic diseases Rheumatoid arthritis Rheumatology Steroids T-Lymphocytes - physiology Womens health United States > US
ISSN:	1759-4790, 1759-4804, 1759-4804
Online Access:	Get full text
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