Acetaminophen attenuates lipopolysaccharide-induced cognitive impairment through antioxidant activity

Background Considerable evidence has shown that neuroinflammation and oxidative stress play an important role in the pathophysiology of postoperative cognitive dysfunction (POCD) and other progressive neurodegenerative disorders. Increasing evidence suggests that acetaminophen (APAP) has unappreciat...

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Bibliographic Details
Published in:	Journal of neuroinflammation Vol. 14; no. 1; p. 17
Main Authors:	Zhao, Wei-Xing, Zhang, Jun-Han, Cao, Jiang-Bei, Wang, Wei, Wang, Dong-Xin, Zhang, Xiao-Ying, Yu, Jun, Zhang, Yong-Yi, Zhang, You-Zhi, Mi, Wei-Dong
Format:	Journal Article
Language:	English
Published:	London BioMed Central 21.01.2017 BioMed Central Ltd Springer Nature B.V
Subjects:	Acetaminophen Acetaminophen - pharmacology Animals Antioxidants Antioxidants - pharmacology Biomedical and Life Sciences Biomedicine Cognition disorders Cognitive Dysfunction - chemically induced Dosage and administration Drug therapy Hippocampus - drug effects Immunology Lipopolysaccharides Lipopolysaccharides - toxicity Male Maze Learning - drug effects Mice Mice, Inbred C57BL Motor Activity - drug effects Neurobiology Neurology Neuroprotective Agents - pharmacology Neurosciences Oxidative stress Memory impairment Acetaminophen Antioxidant activity Neuroinflammation Neuroprotective therapy Apoptosis
ISSN:	1742-2094, 1742-2094
Online Access:	Get full text
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