Enhanced Transcription of Human Endogenous Retroviruses and TRIM28 Downregulation in Patients with Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) includes patients affected by Crohn’s disease or ulcerative colitis. IBD is thought to be a chronic immune-mediated disease, but its origin remains elusive, and this limits new therapeutic approaches. Human endogenous retroviruses (HERVs) originate from ancestral inf...

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Bibliographic Details
Published in:	Viruses Vol. 16; no. 10; p. 1570
Main Authors:	Tovo, Pier-Angelo, Ribaldone, Davide Giuseppe, Galliano, Ilaria, Caviglia, Gian Paolo, Dini, Maddalena, Veglio, Valentina, Calvi, Cristina, Montanari, Paola, Pitoni, Demis, Frara, Simone, Tribocco, Elisa, Poshnjari, Anxhela, Bergallo, Massimiliano
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01.10.2024 MDPI
Subjects:	Adult Aged Analysis Autoimmune diseases Care and treatment Colitis, Ulcerative - genetics Colitis, Ulcerative - virology Control Crohn Disease - genetics Crohn Disease - virology Crohn's disease Diagnosis DNA methylation Down-Regulation Endogenous Retroviruses - genetics Epigenetics Female Gene Products, env - genetics Genes Histone-Lysine N-Methyltransferase human endogenous retroviruses Humans IBD Identification and classification Immune response Immunomodulation Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - genetics Inflammatory Bowel Diseases - virology Intestine Male Microbiota Middle Aged Pathophysiology Patients Physiology, Pathological Pregnancy Proteins - genetics Proteins Retroviruses SETDB1 Syncytin Transcription Transcription activation Transcription, Genetic TRIM28 Tripartite Motif-Containing Protein 28 - genetics Tripartite Motif-Containing Protein 28 - metabolism Ulcerative colitis Young Adult Italy United States > US pathogenesis SETDB1 TRIM28 IBD ulcerative colitis human endogenous retroviruses Crohn’s disease
ISSN:	1999-4915, 1999-4915
Online Access:	Get full text
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