Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS‐CoV‐2

From the beginning of 2002 and 2012, severe respiratory syndrome coronavirus (SARS‐CoV) and Middle East respiratory syndrome coronavirus (MERS‐CoV) crossed the species barriers to infect humans, causing thousands of infections and hundreds of deaths, respectively. Currently, a novel coronavirus (SAR...

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Published in:Journal of medical virology Vol. 92; no. 6; pp. 595 - 601
Main Authors: Liu, Zhixin, Xiao, Xiao, Wei, Xiuli, Li, Jian, Yang, Jing, Tan, Huabing, Zhu, Jianyong, Zhang, Qiwei, Wu, Jianguo, Liu, Long
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01.06.2020
John Wiley and Sons Inc
Subjects:
ACE2
Amino Acid Sequence
Amino acids
Angiotensin
Angiotensin-Converting Enzyme 2
angiotensin‐converting enzyme 2 (ACE2)
Animals
Aquatic reptiles
Betacoronavirus - classification
Betacoronavirus - genetics
Betacoronavirus - pathogenicity
Binding
Binding Sites
Chelonia mydas
China - epidemiology
Chiroptera - virology
Coronaviridae
Coronavirus Disease 2019 (COVID‐19)
Coronavirus Infections - epidemiology
Coronavirus Infections - transmission
Coronavirus Infections - virology
Coronaviruses
COVID-19
Disease transmission
Divergence
Epidemics
Eutheria - virology
Fatalities
Humans
Models, Molecular
Pandemics
Pelodiscus sinensis
Peptidyl-Dipeptidase A - chemistry
Peptidyl-Dipeptidase A - genetics
Peptidyl-Dipeptidase A - metabolism
Phylogeny
Pneumonia, Viral - epidemiology
Pneumonia, Viral - transmission
Pneumonia, Viral - virology
Protein Binding
Protein Conformation, alpha-Helical
Protein Conformation, beta-Strand
Protein Interaction Domains and Motifs
Protein Interaction Mapping
Proteins
Receptors
Receptors, Virus - chemistry
Receptors, Virus - genetics
Receptors, Virus - metabolism
receptor‐binding domain (RBD) of coronavirus
Respiratory diseases
SARS-CoV-2
SARS‐CoV‐2 spike protein (S)
Sequence Alignment
Sequence Homology, Amino Acid
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Snakes - virology
Spike Glycoprotein, Coronavirus - chemistry
Spike Glycoprotein, Coronavirus - classification
Spike Glycoprotein, Coronavirus - genetics
Spike Glycoprotein, Coronavirus - metabolism
Spike protein
Transmission
Turtles
Turtles - virology
Viral diseases
Virology
China
angiotensin-converting enzyme 2 (ACE2)
SARS-CoV-2
Coronavirus Disease 2019 (COVID-19)
SARS-CoV-2 spike protein (S)
receptor-binding domain (RBD) of coronavirus
ISSN:0146-6615, 1096-9071, 1096-9071
Online Access:Get full text
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Summary:From the beginning of 2002 and 2012, severe respiratory syndrome coronavirus (SARS‐CoV) and Middle East respiratory syndrome coronavirus (MERS‐CoV) crossed the species barriers to infect humans, causing thousands of infections and hundreds of deaths, respectively. Currently, a novel coronavirus (SARS‐CoV‐2), which has become the cause of the outbreak of Coronavirus Disease 2019 (COVID‐19), was discovered. Until 18 February 2020, there were 72 533 confirmed COVID‐19 cases (including 10 644 severe cases) and 1872 deaths in China. SARS‐CoV‐2 is spreading among the public and causing substantial burden due to its human‐to‐human transmission. However, the intermediate host of SARS‐CoV‐2 is still unclear. Finding the possible intermediate host of SARS‐CoV‐2 is imperative to prevent further spread of the epidemic. In this study, we used systematic comparison and analysis to predict the interaction between the receptor‐binding domain (RBD) of coronavirus spike protein and the host receptor, angiotensin‐converting enzyme 2 (ACE2). The interaction between the key amino acids of S protein RBD and ACE2 indicated that, other than pangolins and snakes, as previously suggested, turtles (Chrysemys picta bellii, Chelonia mydas, and Pelodiscus sinensis) may act as the potential intermediate hosts transmitting SARS‐CoV‐2 to humans. Highlights The critical residues of S protein RBD binding with ACE2 indicated the potential intermediate hosts transmitting SARS‐CoV‐2 to humans.
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ISSN:0146-6615
1096-9071
1096-9071
DOI:10.1002/jmv.25726