CREDENCE: A silver lining in the dark cloud of diabetic nephropathy

[...]SGLT2 inhibitors have a strong effect in reducing the risk of deteriorating heart failure, which is closely associated with advanced diabetic nephropathy. A recent study of patients with heart failure and a reduced ejection fraction showed that the risk of deteriorating heart failure or death f...

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Veröffentlicht in:Journal of diabetes investigation Jg. 11; H. 3; S. 527 - 529
Hauptverfasser: Hanai, Ko, Babazono, Tetsuya
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Japan John Wiley & Sons, Inc 01.05.2020
John Wiley and Sons Inc
Wiley
Schlagworte:
Antidiabetics
Blood pressure
Canagliflozin - therapeutic use
Cardiovascular disease
Clinical trials
Commentaries
Confidence intervals
Congestive heart failure
Diabetes
Diabetes mellitus
Diabetic Nephropathies - diagnosis
Diabetic Nephropathies - drug therapy
Diabetic Nephropathies - epidemiology
Diabetic nephropathy
Enzymes
Glucose
Heart failure
Humans
Kidney diseases
Kidney Failure, Chronic - diagnosis
Kidney Failure, Chronic - epidemiology
Kidney Failure, Chronic - prevention & control
Nephropathy
Peptides
Randomized Controlled Trials as Topic - methods
Sodium-Glucose Transporter 2 Inhibitors - therapeutic use
ISSN:2040-1116, 2040-1124, 2040-1124
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Abstract [...]SGLT2 inhibitors have a strong effect in reducing the risk of deteriorating heart failure, which is closely associated with advanced diabetic nephropathy. A recent study of patients with heart failure and a reduced ejection fraction showed that the risk of deteriorating heart failure or death from cardiovascular causes was lower in the dapagliflozin group than in the placebo group, regardless of the presence of diabetes . [...]the kidney‐protective effects observed in the CREDENCE study might have been noted because of the interruption of the vicious circle involving diabetic nephropathy and heart failure . [...]the CREDENCE study has provided evidence that canagliflozin administration is a beneficial therapy that delays kidney disease progression in patients with advanced diabetic nephropathy.
AbstractList [...]SGLT2 inhibitors have a strong effect in reducing the risk of deteriorating heart failure, which is closely associated with advanced diabetic nephropathy. A recent study of patients with heart failure and a reduced ejection fraction showed that the risk of deteriorating heart failure or death from cardiovascular causes was lower in the dapagliflozin group than in the placebo group, regardless of the presence of diabetes . [...]the kidney‐protective effects observed in the CREDENCE study might have been noted because of the interruption of the vicious circle involving diabetic nephropathy and heart failure . [...]the CREDENCE study has provided evidence that canagliflozin administration is a beneficial therapy that delays kidney disease progression in patients with advanced diabetic nephropathy.
Author Hanai, Ko
Babazono, Tetsuya
AuthorAffiliation 1 Diabetes Center Tokyo Women’s Medical University School of Medicine Tokyo Japan
AuthorAffiliation_xml – name: 1 Diabetes Center Tokyo Women’s Medical University School of Medicine Tokyo Japan
Author_xml – sequence: 1
  givenname: Ko
  orcidid: 0000-0002-6370-7543
  surname: Hanai
  fullname: Hanai, Ko
  email: hanai.dmc@twmu.ac.jp
  organization: Tokyo Women’s Medical University School of Medicine
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  givenname: Tetsuya
  orcidid: 0000-0001-8545-3604
  surname: Babazono
  fullname: Babazono, Tetsuya
  organization: Tokyo Women’s Medical University School of Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31705732$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1681/ASN.2019010064
10.1056/NEJMoa1911303
10.1161/CIRCULATIONAHA.118.038868
10.1016/S2213-8587(18)30141-4
10.1056/NEJMoa1515920
10.1056/NEJMoa1811744
10.2337/dc19-S011
10.1016/j.jclinepi.2009.08.006
10.1161/CIRCULATIONAHA.118.035901
10.1161/CIRCULATIONAHA.113.005081
10.1016/j.jacc.2018.06.040
10.1056/NEJMoa1611925
10.1056/NEJMoa1812389
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Snippet [...]SGLT2 inhibitors have a strong effect in reducing the risk of deteriorating heart failure, which is closely associated with advanced diabetic nephropathy....
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StartPage 527
SubjectTerms Antidiabetics
Blood pressure
Canagliflozin - therapeutic use
Cardiovascular disease
Clinical trials
Commentaries
Confidence intervals
Congestive heart failure
Diabetes
Diabetes mellitus
Diabetic Nephropathies - diagnosis
Diabetic Nephropathies - drug therapy
Diabetic Nephropathies - epidemiology
Diabetic nephropathy
Enzymes
Glucose
Heart failure
Humans
Kidney diseases
Kidney Failure, Chronic - diagnosis
Kidney Failure, Chronic - epidemiology
Kidney Failure, Chronic - prevention & control
Nephropathy
Peptides
Randomized Controlled Trials as Topic - methods
Sodium-Glucose Transporter 2 Inhibitors - therapeutic use
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Title CREDENCE: A silver lining in the dark cloud of diabetic nephropathy
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