Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors

An enzyme‐responsive, paclitaxel‐loaded nanoparticle is described and assessed in vivo in a human fibrosarcoma murine xenograft. This work represents a proof‐of‐concept study demonstrating the utility of enzyme‐responsive nanoscale drug carriers capable of targeted accumulation and retention in tumo...

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Vydáno v:	Advanced materials (Weinheim) Ročník 27; číslo 31; s. 4611 - 4615
Hlavní autoři:	Callmann, Cassandra E., Barback, Christopher V., Thompson, Matthew P., Hall, David J., Mattrey, Robert F., Gianneschi, Nathan C.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Germany Blackwell Publishing Ltd 19.08.2015
Témata:	Animals Antineoplastic Agents, Phytogenic - administration & dosage Biomedical materials Cell Line, Tumor Cohort Studies Drug Carriers - chemistry drug delivery Drug Evaluation, Preclinical enzyme-responsive Fibrosarcoma - drug therapy Fibrosarcoma - enzymology Fluorescence Resonance Energy Transfer Human Humans In vivo testing In vivo tests Matrix Metalloproteinases - metabolism Maximum Tolerated Dose Mice, Nude Micelles Microscopy, Electron, Transmission nanomaterials Nanoparticles Nanoparticles - chemistry Neoplasm Transplantation Optical Imaging Paclitaxel - administration & dosage Polymers - chemistry self-assembly stimuli-responsive Surgical implants Tumor Burden Tumors Utilities self-assembly nanomaterials drug delivery enzyme-responsive stimuli-responsive
ISSN:	0935-9648, 1521-4095
On-line přístup:	Získat plný text
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