A sharp T-cell antigen receptor signaling threshold for T-cell proliferation

T-cell antigen receptor (TCR) signaling is essential for activation, proliferation, and effector function of T cells. Modulation of both intensity and duration of TCR signaling can regulate these events. However, it remains unclear how individual T cells integrate such signals over time to make crit...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 111; číslo 35; s. E3679
Hlavní autori:	Au-Yeung, Byron B, Zikherman, Julie, Mueller, James L, Ashouri, Judith F, Matloubian, Mehrdad, Cheng, Debra A, Chen, Yiling, Shokat, Kevan M, Weiss, Arthur
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 02.09.2014
Predmet:	Adoptive Transfer Animals CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Proliferation Female Green Fluorescent Proteins - genetics Interleukin-2 - metabolism Male Mice Mice, Inbred C57BL Mice, Transgenic Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Signal Transduction - immunology ZAP-70 Protein-Tyrosine Kinase - genetics ZAP-70 Protein-Tyrosine Kinase - metabolism
ISSN:	1091-6490, 1091-6490
On-line prístup:	Zistit podrobnosti o prístupe
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