A sharp T-cell antigen receptor signaling threshold for T-cell proliferation

T-cell antigen receptor (TCR) signaling is essential for activation, proliferation, and effector function of T cells. Modulation of both intensity and duration of TCR signaling can regulate these events. However, it remains unclear how individual T cells integrate such signals over time to make crit...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 35; p. E3679
Main Authors:	Au-Yeung, Byron B, Zikherman, Julie, Mueller, James L, Ashouri, Judith F, Matloubian, Mehrdad, Cheng, Debra A, Chen, Yiling, Shokat, Kevan M, Weiss, Arthur
Format:	Journal Article
Language:	English
Published:	United States 02.09.2014
Subjects:	Adoptive Transfer Animals CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Proliferation Female Green Fluorescent Proteins - genetics Interleukin-2 - metabolism Male Mice Mice, Inbred C57BL Mice, Transgenic Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics Nuclear Receptor Subfamily 4, Group A, Member 1 - metabolism Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Signal Transduction - immunology ZAP-70 Protein-Tyrosine Kinase - genetics ZAP-70 Protein-Tyrosine Kinase - metabolism
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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