ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation

Ferroptosis is a novel form of programmed cell death in which the accumulation of intracellular iron promotes lipid peroxidation, leading to cell death. Recently, the induction of autophagy has been suggested during ferroptosis. However, this relationship between autophagy and ferroptosis is still c...

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Bibliographic Details
Published in:	Cell death & disease Vol. 10; no. 11; pp. 822 - 10
Main Authors:	Park, Eunhee, Chung, Su Wol
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 28.10.2019 Springer Nature B.V
Subjects:	13/109 13/2 13/31 631/80/82/23 631/80/82/39 64/60 82/1 82/29 82/80 Antibodies Antigens, CD - genetics Apoptosis Apoptosis - genetics Autophagy Autophagy - genetics Beclin-1 - genetics Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell death Cell survival Cytoplasm - genetics Cytoplasm - metabolism Ferritin Ferroptosis Ferroptosis - drug effects Ferroptosis - genetics Humans Immunology Intracellular Iron Iron - metabolism Life Sciences Lipid peroxidation Lipid Peroxidation - genetics Microtubule-Associated Proteins - genetics Phagocytosis Piperazines - toxicity Reactive oxygen species Reactive Oxygen Species - metabolism Receptors, Transferrin - genetics Transferrins
ISSN:	2041-4889, 2041-4889
Online Access:	Get full text
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