Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination Studies

Despite a strong preclinical rationale for targeting the insulin-like growth factor (IGF) axis in cancer, clinical studies of IGF-1 receptor (IGF-1R)-targeted monotherapies have been largely disappointing, and any potential success has been limited by the lack of validated predictive biomarkers for...

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Bibliographic Details
Published in:	Targeted oncology Vol. 12; no. 5; pp. 571 - 597
Main Authors:	Simpson, Aaron, Petnga, Wilfride, Macaulay, Valentine M., Weyer-Czernilofsky, Ulrike, Bogenrieder, Thomas
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01.10.2017 Springer Nature B.V
Subjects:	Antineoplastic Agents - pharmacology Biomedicine Cancer Drug Resistance, Neoplasm - physiology Humans Insulin Insulin-like growth factors Ligands Medicine Medicine & Public Health Metabolism Neoplasms - drug therapy Oncology Receptor, IGF Type 1 - antagonists & inhibitors Review Review Article Targeted cancer therapy Treatment resistance
ISSN:	1776-2596, 1776-260X, 1776-260X
Online Access:	Get full text
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